San Francisco 49ers vs. Detroit Lions NFL Betting Preview, Lines, Odds, Insights, and Trends for September 12, 2021

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BetMGM Sep 27, 2021, 3:04 PM

The San Francisco 49ers (0-0) square off against the Detroit Lions (0-0) on Sunday, September 12, 2021 at Ford Field. The 49ers are considerable favorites in this one, with the spread posted at 7.5 points. The over/under is set at 46 in the contest. Click here to bet on San Francisco vs Detroit and other NFL games with BetMGM.

Where to watch

  • Game Day: Sunday, September 12, 2021
  • Game Time: 1:00 PM ET
  • TV Channel: FOX
  • Location: Detroit, Michigan
  • Stadium: Ford Field

49ers vs Lions Betting Information
FavoriteSpreadFavorite Spread OddsUnderdog Spread OddsTotalOver Total OddsUnder Total OddsFavorite MoneylineUnderdog Moneyline
49ers-7.5-105-11546-110-110-350+280

Betting on the 49ers

  • San Francisco put together a 7-9-0 ATS record last year.
  • The 49ers were favored by 7.5 points or more last season twice, and failed to cover both times.
  • Last season, the combined scoring went over the point total eight times in San Francisco's games.
  • Based on this contest's moneyline, the 49ers have an implied win probability of 77.8%.
  • The 49ers were favored on the moneyline eight total times last season. They went 2-6 in those games.
  • San Francisco played as a moneyline favorite of -350 or shorter in just two games last season, and they lost both.

Betting on the Lions

  • Detroit went 7-9-0 ATS last season.
  • The Lions were an underdog by 7.5 points or more three times last year, and covered the spread in one of those contests.
  • Detroit and its opponents combined to go over the point total 10 out of 16 times last year.
  • The sportsbooks' moneyline implies a 26.3% chance of a victory for the Lions.
  • The Lions were underdogs in 12 games last season and won three (25%) of those contests.
  • Last season, Detroit was at least a +280 underdog on the moneyline three times, losing each of those contests.

Betting on the Total - What to Look For

  • San Francisco's 16 games last season went over this contest's total of 46 points six times.
  • Detroit combined with its opponent to score more than 46 points in 14 of 16 games last season.
  • The teams combined to score 47.1 points per game last season, 1.1 more points than this matchup's total.
  • Combined, these teams allowed 56.8 points per contest last year, 10.8 more points than the over/under for this game.
  • The 49ers had an average total of 47.1 in their matchups last season, 1.1 more points than the over/under for this game.
  • The average over/under for Lions outings last year was 50.9, 4.9 more points than this game's point total.

49ers Key Players

  • Jimmy Garoppolo collected 1,096 passing yards (137 yards per game) with a 67.1% completion percentage last year (94-of-140), while throwing seven touchdowns and five interceptions.
  • Raheem Mostert rushed for 521 yards on 104 carries (52.1 yards per game) while scoring two touchdowns a season ago. He also averaged 15.6 receiving yards per game, grabbing 16 passes for 156 yards and one touchdown.
  • JaMycal Hasty amassed 148 rushing yards on 39 carries (18.5 yards per game), with one touchdown on the ground, last year.
  • Last season, Brandon Aiyuk was targeted 96 times and had 60 catches for 748 yards (46.8 ypg) with five touchdowns.
  • George Kittle also contributed with 48 catches for 634 yards and two touchdowns last year. He was targeted 63 times and averaged 63.4 receiving yards per game.
  • Deebo Samuel caught 33 passes on 44 targets for 391 yards and one touchdown, averaging 30.1 yards per game last season.
  • Last season, Samson Ebukam racked up 4.5 sacks, five TFL and 44 tackles.
  • Fred Warner racked up 170 tackles, six TFL, one sack, and two interceptions over the course of his last campaign.
  • Last season, Jason Verrett hauled in two interceptions and added 70 tackles, two TFL, and seven passes defended.

49ers Injuries:Jason Verrett: Out (Hamstring),Brandon Aiyuk: Questionable (Hamstring),Ben Garland: Questionable (Ankle),Deebo Samuel: Out (Foot)

Lions Key Players

  • Jared Goff threw for 3,952 yards while completing 67% of his passes (370-of-552), with 20 touchdowns and 13 interceptions last year (247 yards per game).
  • D'Andre Swift took 114 attempts for 521 rushing yards a season ago (32.6 yards per game) while scoring eight touchdowns. He also caught 46 passes for 357 yards (22.3 receiving yards per game) with two touchdowns through the air.
  • Jamaal Williams amassed 505 rushing yards on 119 carries (31.6 yards per game), with two touchdowns on the ground last season.
  • T.J. Hockenson reeled in 67 passes for 723 yards last season with six touchdowns. He was targeted 101 times, and averaged 45.2 yards per game.
  • Quintez Cephus racked up 349 yards on 20 catches with two touchdowns in 2020, averaging 21.8 yards per game (on 35 targets).
  • Last season Romeo Okwara piled up 10 sacks, 14 TFL and 56 tackles.
  • Over his 2020 campaign, Jamie Collins Sr. collected 147 tackles, 6.5 TFL, one sack, and one interception.
  • Dean Marlowe intercepted two passes and tacked on 28 tackles, 2.5 TFL, 1.5 sacks, and three passes defended last season.

Lions Injuries:Jeff Okudah: Questionable (Hamstring),Hunter Bryant: Out (Hamstring),Darryl Roberts: Questionable (Groin),Kenny Golladay: Doubtful (Hamstring),Julian Okwara: Questionable (Knee),Danny Amendola: Questionable (Hamstring),Da'Shawn Hand: Questionable (Groin),C.J. Moore: Out (Hamstring),Halapoulivaati Vaitai: Out (Foot)

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.