Big Ten College Football Betting Odds for Week 4

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BetMGM Staff @BETMGM Sep 23, 2021, 2:09 PM

Week 4 of the Big Ten is heating up as teams enter conference play. There are several key matchups this week, with several of them featuring 3-0 teams. ESPN’s College GameDay visits Chicago for the matchup between #12 Notre Dame and #18 Wisconsin.

With so many big matchups this week, there should be plenty of betting action. So, let’s take a look at the college football betting odds for Week 4 in the Big Ten.

Nebraska at Michigan State

The 2-2 Huskers head to 3-0 Michigan State looking to rebound from a tough loss against Oklahoma last weekend.

Nebraska is hurting thanks to a weak offensive line, and they will also be without the services of running back Gabe Ervin.

Nebraska’s kicking game is highly questionable, with Connor Culp missing five field goals and three extra points this season.

The bright spot for Nebraska is its defense. Will it be strong enough to stop Michigan State’s Kenneth Walker, III? That’s the key question heading into this matchup.

  • Spread: Michigan State -5
  • Total: Over/Under 51.5
  • Money Line: Nebraska +175, Michigan State -225

Notre Dame vs. Wisconsin

These two top-25 teams head to Soldier Field in Chicago for the week’s biggest showdown. Notre Dame’s offensive line looks especially vulnerable at left tackle. Look for Wisconsin’s defense to attack that side of the line and have a strong day.

  • Spread: Wisconsin -5.5
  • Total: Over/Under 46.5
  • Money Line: Notre Dame +180, Wisconsin -225

Rutgers at Michigan 

You’d have to go back to 2012 for the last time the Scarlet Knights started the season at 3-0. Unfortunately, that winning streak is in danger this week, as Rutgers travels to The Big House to begin conference play against Michigan.

Delaware was able to establish its ground game against Rutgers in Week 3. Look for Michigan to attempt to do the same.

  • Spread: Michigan -18.5
  • Total: Over/Under 51.5

Colorado State at Iowa

The NCAAF playoff odds for No. 5 Iowa is +5000 to reach the college football playoffs. The Hawkeyes lead the Big Ten West with a 3-0 record, while the Rams are 1-2. I believe that Iowa will win this game by a wide margin.

  • Spread: Iowa -22.5
  • Total: Over/Under 44.5
  • Money Line: Colorado State +1200, Iowa -2500

Illinois at Purdue

Illinois comes into this game with a three-game losing streak. Don’t expect things to get any easier as they face a tough Purdue team. The good news for the Illini is that they may see some players back from injuries.

  • Spread: Purdue -11
  • Total: Over/Under 55
  • Money Line: Illinois +350, Purdue -450

Ohio at Northwestern

Winless Ohio faces 1-2 Northwestern. Northwestern is the favorite here, but I’m expecting Ohio’s defense to have a strong day against the passing game. Northwestern’s QB Hunter Johnson has given up 4 INT’s this year.

  • Spread: Northwestern -15
  • Total: Over/Under 47.5
  • Money Line: Ohio +525, Northwestern -750

Akron at Ohio State

The Buckeyes are a bit of a mystery this year. This game could be tricky for bettors, as Ohio State hasn’t been as dominant as expected through their first three games.

  • Spread: Ohio State -48
  • Total: Over/Under 67.5

Bowling Green at Minnesota

Minnesota leads the country with 21 straight non-conference wins. They shouldn’t have a problem extending that streak against Bowling Green.

  • Spread: Minnesota -31
  • Total: Over/Under 51.5
  • Money Line: Bowling Green +3000, Minnesota -10000

Indiana at Western Kentucky

Indiana has yet to lose against Western Kentucky, with a 3-0 record. The teams last met in 2019, when Indiana won 38-35.

  • Spread: Indiana -9
  • Total: Over/Under 62.5
  • Money Line: Indiana -375, WKU +300

Villanova at Penn State

Penn State comes off an impressive win, beating Auburn 28-20. This week, they’ll face FCS team Villanova, who’s also 3-0.

Things could get out of hand early in this game. If they do, look for Penn State to rest some starters and feature its young players in the second half.

Week 4 Big Ten College Football Betting Odds

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Our BetMGM authors are sports experts, with a wealth of knowledge of the sports betting industry at all levels. Their coverage includes sports news across players, teams and coaches, providing betting previews and predictions, fun facts and more.

Our BetMGM authors are sports experts, with a wealth of knowledge of the sports betting industry at all levels. Their coverage includes sports news across players, teams and coaches, providing betting previews and predictions, fun facts and more.