Biggest NFL Betting Upsets of Last 10 Years

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Jaguars Bills Josh Allen
(AP Foto/Phelan M. Ebenhack)
Andrew Doughty @DoughtyBetMGM Dec 11, 2022, 2:44 PM

The Buffalo Bills committed 12 penalties, allowed four sacks, committed three turnovers, and scored six points as they failed to cover a 16-point spread in a loss to the Jacksonville Jaguars in 2021.

In gifting Urban Meyer one of his two career NFL victories, the Bills became just the fourth team to lose outright in the last decade when favored by at least 15 points.

Three years earlier, Sean McDermott and the Bills were on the other side of a shocking upset.

In Josh Allen’s first career start, it was the Bills who forced three turnovers and allowed six points in a 21-point over the Minnesota Vikings, a 16.5-point favorite. It remains the only game since 2009 in which an underdog of at least 10 points won by at least 21 points.

The Carolina Panthers nearly accomplished that feat in this year’s Week 7 win over the Tampa Bay Buccaneers. Still, the Panthers’ 18-point win as a 13.5-point underdog was one of the biggest NFL betting upsets of the decade.

Here’s the full list:

Biggest NFL Betting Upsets of Last 10 Years

SeasonMatchupFinal Score
2020Jets at Rams (-17.5)Jets 23-20
2019Dolphins at Patriots (-17.5)Dolphins 27-24
2018Bills at Vikings (-16.5)Bills 27-6
2021Bills at Jaguars (-16)Jaguars 9-6
2020Steelers at Bengals (-14.5)Bengals 27-17
2021Colts (-14) at JaguarsJaguars 26-11
2019Falcons at Saints (-14)Falcons 26-9
2017Dolphins (-14) at FalconsDolphins 20-17
2017Giants (-14) at BroncosGiants 23-10
2022Bucs at Panthers (-13.5)Panthers 21-3
2018Eagles (-13.5) at RamsEagles 30-23
2018Cardinals (-13.5) at PackersCardinals 20-17

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About the Author

Andrew Doughty

Read More @DoughtyBetMGM

Andrew Doughty is a writer for BetMGM with a focus on college football, NFL, college basketball, and NASCAR. A graduate of the University of Kansas, he previously wrote for Sports Illustrated and HERO Sports.

Andrew Doughty is a writer for BetMGM with a focus on college football, NFL, college basketball, and NASCAR. A graduate of the University of Kansas, he previously wrote for Sports Illustrated and HERO Sports.