- The 49ers are -6.5 point favorites vs the Chargers
- Total (Over/Under): 37.5 points
- Watch the game on NFL Network
The Los Angeles Chargers visit Levi’s Stadium to take on the San Francisco 49ers on Aug. 25. Kickoff is scheduled for 10:00pm EDT in Santa Clara.
The 49ers are betting favorites in this preseason matchup, with the spread sitting at -6.5 (-105).
The Chargers vs. 49ers Over/Under is 37.5 total points for the game.
Bet now on 49ers vs Chargers & all NFL games with BetMGM
Chargers vs. 49ers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Chargers | +6.5 -115 | 37.5 -110 | +200 |
| 49ers | -6.5 -105 | 37.5 -110 | -250 |
Chargers vs. 49ers Prediction
Based on recent trends, the winning team model predicts the 49ers will win this preseason game with 56.9% confidence.
Chargers vs 49ers Spread Prediction
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 53.0% confidence.
Both predictions factor in up-to-date player injuries for both the Chargers and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.
Bet now on 49ers vs Chargers and all NFL games with BetMGM
Best Chargers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Chargers players this preseason game, looking at profitable historical betting trends:
- Gerald Everett has hit the Receptions Over in 8 of his last 9 games (+7.35 Units / 77% ROI)
- Justin Herbert has hit the TD Passes Under in 9 of his last 13 games (+6.50 Units / 48% ROI)
- Josh Palmer has hit the Longest Reception Under in his last 6 games (+6.00 Units / 79% ROI)
- Justin Herbert has hit the Pass Attempts Over in 10 of his last 14 games (+5.55 Units / 35% ROI)
- Justin Herbert has hit the Passing Yards Under in 6 of his last 7 away games (+4.70 Units / 51% ROI)
Best 49ers Player Prop Best Bets Today
And here are some top NFL player prop bets for 49ers players for this preseason matchup, looking at profitable historical betting trends:
- George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
- Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
- Christian McCaffrey has hit the Longest Rush Over in 12 of his last 17 games (+6.10 Units / 32% ROI)
- Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)
Chargers Against the Spread (ATS) Record
Against the spread this NFL preseason, the Chargers went 1-0 (+1 Units / 90.91% ROI).
- Chargers are 1-0 when betting on the Moneyline for +1.2 Units / 120% ROI
- Chargers are 1-0 when betting the Over for +1 Units / 90.91% ROI
- Chargers are 0-1 when betting the Under for -1.1 Units / ROI
49ers Against the Spread (ATS) Record
Against the spread this NFL preseason, the 49ers went 0-1 (-1.15 Units / -100% ROI).
- 49ers are 0-1 when betting on the Moneyline for -2 Units / -100% ROI
- 49ers are 1-0 when betting the Over for +1 Units / 90.91% ROI
- 49ers are 0-1 when betting the Under for -1.1 Units / -100% ROI
Los Angeles Chargers: Keys to the Game vs. the San Francisco 49ers
The Chargers are 6-1 (.857) when averaging more than 5 yards per rush since the 2021 season — 2nd-best in NFL; League Avg: .529.
The Chargers were 7-2 (.778) when not losing a fumble in the 2022 season — 7th-best in NFL; League Avg: .577.
The Chargers are winless (0-3) when having a TO margin of -2 or worse since the 2021 season — tied for worst in NFL; League Avg: .123.
The Chargers were 6-1 (.857) when allowing less than 5 explosive passes in the 2022 season — 3rd-best in NFL; League Avg: .544.
San Francisco 49ers: Keys to the Game vs. the Los Angeles Chargers
The 49ers are undefeated (14-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .547.
The 49ers are 9-3 (.750) vs top 10 pass offenses since the 2021 season — 2nd-best in NFL; League Avg: .352.
The 49ers were undefeated (8-0) when the opposing team converts less than 55% of its red zone chances into touchdowns in the 2022 season — best in NFL; League Avg: .559.
The 49ers are undefeated (7-0) when committing less than 30 yards in penalties since the 2021 season — tied for best in NFL; League Avg: .538.
Additional Matchup Notes for Los Angeles Chargers vs. San Francisco 49ers
The 49ers had a third down conversion rate of 29.8% on 3rd and 10+ YTG last season — third-best in NFL. The Chargers defense allowed a third down conversion rate of 27.3% on 3rd and 10+ YTG last season — worst in NFL.
49ers RBs averaged 111.9 rushing yards per game last season — fifth-best in NFL. The Chargers allowed an average of 146.4 rushing yards per game last season — fifth-worst in NFL.
49ers TEs gained 927 yards on 67 receptions (13.8 YPR) last season — best in NFL. The Chargers allowed 13.9 Yards Per Reception to TEs last season — second-worst in NFL.
The Chargers averaged just 4.0 yards per carry last season — tied for fifth-worst in NFL. The 49ers allowed just 3.5 yards per carry last season — tied for best in NFL.
Chargers WRs had 68 receptions in 4 games (17.0 per game) in the last 4 weeks of the regular season — fourth-best in NFL. The 49ers allowed 14.0 receptions per game to WRs in the last 4 weeks of the regular season — tied for fifth-worst in NFL.
The Chargers averaged just 3.7 yards per carry on rushes to the left side of the field last season — third-worst in NFL. The 49ers allowed just 3.4 yards per carry when defending on rushes to the left last season — best in NFL.
Los Angeles Chargers Offense: Important Stats
The Chargers ran the ball on 34% of plays (386 carries/1,152 plays) in the 2022 season — 2nd-lowest in NFL; League Avg: 42%.
The Chargers have an average drive start position from the 30.1 yard line in the 1st quarter since the 2021 season — 2nd-best in NFL; League Avg: 25.7.
The Chargers ran successful plays on 39% of rush attempts in the 2nd half in the 2022 season — 3rd-worst in NFL; League Avg: 44%.
The Chargers are averaging 10.2 drives per TD in the 3rd quarter since the 2021 season — 2nd-worst Drives Per TD rate in NFL; League Avg: 5.3.
San Francisco 49ers Offense: Important Stats
The 49ers went three and out on 14% of their drives in the 2022 season — best in NFL; League Avg: 21%.
The 49ers had 6 TDs that were 20+ yards in the last 4 weeks of the regular season — most in NFL.
The 49ers have completed passes for 20+ yards on 119 of their 1,024 total passing attempts (12%) since the 2021 season — best in NFL; League Avg: 9%.
The 49ers have faced a blitz 222 times since the 2021 season — fewest in NFL.
Los Angeles Chargers Defense: Important Stats
The Chargers defense allowed an average of 2.3 yards after contact per carry (447 carries) in the 2022 season — worst in NFL; League Avg: 1.7.
The Chargers defense allowed an average of 2.5 yards after contact per carry (386 carries) to RBs in the 2022 season — worst in NFL; League Avg: 1.8.
The Chargers defense allowed first downs on 12% of pass attempts on 3rd down in the last 4 weeks of the regular season — best in NFL; League Avg: 37%.
The Chargers defense allowed successful plays on 58% of rush attempts in the 3rd quarter in the 2022 season — worst in NFL; League Avg: 45%.
San Francisco 49ers Defense: Important Stats
The 49ers defense allowed just 15.2 points per game to opposing offenses (259 points / 17 games) in the 2022 season — best in NFL; League Avg: 20.8.
The 49ers defense allowed scores on 26% of opponent drives in the 2022 season — best in NFL; League Avg: 36%.
The 49ers defense allowed successful plays on 27% of rush attempts in the 1st quarter in the 2022 season — best in NFL; League Avg: 42%.
The 49ers defense allowed 16.4 Points per Game (279/17) in the 2022 season — worst in NFL; League Avg: 21.8.
Looking to place a bet on this game with a First Bet Offer up to $1,000? Bet now on 49ers vs Chargers and all NFL games with BetMGM
Bet on NFL Odds at BetMGM
At BetMGM, you can bet online with updated NFL betting odds. And with live sports betting, the best online sports betting and mobile sports betting (with the BetMGM Sportsbook app) experiences are at BetMGM.
