As the final week of September arrives, many teams are done with their nonconference schedule and moving firmly into league play.
That’s going to vastly cut down on the number of 40- and 50-point favorites available to bet in the weekly college football spreads market.Â
Still, even in league play, there are a handful of big favorites every week. And as the conference season unfolds and intra-conference disparities become clear, those point spreads will begin to widen again.
These are the biggest spreads of Week 4.Â
Tulane -18.5 vs. Southern Miss
Kentucky -20.5 vs. South Alabama
Indiana -21 vs. Northwestern
Ohio State -27 vs. Illinois
Notre Dame -27 vs. Purdue
SMU -34.5 vs. Missouri State
Texas Tech -35.5 vs. Sam Houston
Miami -41 vs. Central Michigan
Biggest Favorites For College Football Week 4 (2026)
- Miami -41
- Texas Tech -35.5
- SMU -34.5
- Notre Dame -27
- Ohio State -27
- Indiana -21
- Kentucky -20.5
- Tulane -18.5
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