Duke vs Clemson Prediction, Odds & Best Prop Bets – NCAAF, Week 10

• Clemson is a -3.5 point favorite vs. Duke
• Duke vs. Clemson Total (Over/Under): 55.5 points
• TV Channel: ACCN

Duke (4-3) visit Memorial Stadium to take on Clemson (3-4) on Nov. 1 in Clemson, SC. Kickoff is scheduled for 12:00pm EDT.

Clemson is a betting favorite in Week 10, with the spread sitting at -3.5 (-110).

The Duke vs. Clemson Over/Under is 55.5 total points.

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Duke vs. Clemson Odds, Spread, Over/Under:

Duke vs Clemson Prediction:

The winning team model predicts Clemson will win this game with 59.0% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Duke and Clemson, key player performances this season and recent team trends.

Duke vs Clemson Spread Prediction:

Based on recent against-the-spread trends, the model predicts Duke will cover the spread with 51.7% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Duke Best Bets Today

• Duke has hit the 1H Moneyline in 6 of their last 12 games (+6.20 Units / 10% ROI)
• Duke has hit the 1Q Game Total Over in 5 of their last 7 away games (+3.90 Units / 48% ROI)
• Duke has hit the Game Total Over in 8 of their last 12 games (+3.60 Units / 27% ROI)
• Duke has hit the Team Total Over in 4 of their last 5 games (+2.85 Units / 49% ROI)
• Duke has hit the Moneyline in 4 of their last 7 away games (+1.30 Units / 14% ROI)

Clemson Best Bets Today

• Clemson has hit the 1Q Game Total Under in 5 of their last 6 games at home (+3.85 Units / 55% ROI)
• Clemson has hit the 1H Game Total Under in 5 of their last 6 games at home (+3.80 Units / 55% ROI)
• Clemson has hit the Team Total Under in 5 of their last 7 games (+2.60 Units / 32% ROI)
• Clemson has hit the Game Total Under in 8 of their last 14 games (+2.50 Units / 16% ROI)

Duke Against the Spread (ATS) Record

Duke is 3-4 against the spread this college football season (-1.35 Units / -17.65% ROI).

• Duke is 3-3 when betting on the Moneyline for -0.65 Units / -7.47% ROI
• Duke is 5-2 when betting the Over for +2.8 Units / 36.36% ROI
• Duke is 2-5 when betting the Under for -3.5 Units / -45.45% ROI

Clemson Against the Spread (ATS) Record

Clemson iss 2-5 against the spread this college football season (-3.45 Units / -45.1% ROI).

• Clemson is 2-4 when betting on the Moneyline for -11.15 Units / -44.51% ROI
• Clemson is 2-4 when betting the Over for -2.4 Units / -31.17% ROI
• Clemson is 4-2 when betting the Under for +1.8 Units / 23.38% ROI

Duke: Keys to the Game vs. Clemson

Duke’s offense has thrown for 20 or more yards on 14.6% of 254 attempts this season — 12th-best among FBS offenses. Clemson’s defense allowed 20+ yards on just 5.6% of attempts this season — T-6th-best among FBS defenses.

Duke’s WRs has 343 receptions in 20 games (17.2 per game) since the 2024 season — T-7th-best among FBS WRs. Clemson’s defense has allowed 19.8 receptions per game since the 2024 season — T-31st-worst among FBS defenses.

Duke’s offense has thrown for 20 or more yards on 14.6% of 254 attempts this season — 12th-best among FBS offenses. Clemson’s defense allowed 20+ yards on just 5.6% of attempts this season — 2nd-best among ACC defenses.

Duke’s TEs has 20 receptions in 7 games (just 2.9 per game) this season — 4th-worst among ACC TEs. Clemson’s defense has allowed 4.3 receptions per game to TEs this season — T-21st-worst among FBS defenses.

Duke RBs have averaged 9.5 Yards per Carry (409 yards/43 carries) in the 4th quarter this season– best among FBS Teams; Average: 4.9

Clemson: Keys to the Game vs. Duke

Clemson was undefeated (7-0) when allowing less than 5 yards per rush last season– T-best among Power Conference Teams; Average: .647

Clemson was 5-2 (.714) when their opponent rushed more than 30 times last season– 15th-best among Power Conference Teams; Average: .481

Clemson was 10-2 (.833) when making 5 or more explosive passes in a game last season– T-9th-best among Power Conference Teams; Average: .631

Clemson was 8-2 (.800) when allowing less than 50% of third down conversion opportunities last season– T-27th-best in FBS; Average: .602

Matchup Notes for Duke vs. Clemson

Clemson was undefeated (7-0) when allowing less than 5 yards per rush last season– T-best among Power Conference Teams; Average: .647

Clemson was 5-2 (.714) when their opponent rushed more than 30 times last season– 15th-best among Power Conference Teams; Average: .481

Clemson was 10-2 (.833) when making 5 or more explosive passes in a game last season– T-9th-best among Power Conference Teams; Average: .631

Clemson was 8-2 (.800) when allowing less than 50% of third down conversion opportunities last season– T-27th-best in FBS; Average: .602

Duke’s offense has thrown for 20 or more yards on 14.6% of 254 attempts this season — 12th-best among FBS offenses. Clemson’s defense allowed 20+ yards on just 5.6% of attempts this season — T-6th-best among FBS defenses.

Duke’s WRs has 343 receptions in 20 games (17.2 per game) since the 2024 season — T-7th-best among FBS WRs. Clemson’s defense has allowed 19.8 receptions per game since the 2024 season — T-31st-worst among FBS defenses.

Duke’s offense has thrown for 20 or more yards on 14.6% of 254 attempts this season — 12th-best among FBS offenses. Clemson’s defense allowed 20+ yards on just 5.6% of attempts this season — 2nd-best among ACC defenses.

Duke’s TEs has 20 receptions in 7 games (just 2.9 per game) this season — 4th-worst among ACC TEs. Clemson’s defense has allowed 4.3 receptions per game to TEs this season — T-21st-worst among FBS defenses.

Duke RBs have averaged 9.5 Yards per Carry (409 yards/43 carries) in the 4th quarter this season– best among FBS Teams; Average: 4.9

Duke Offensive Stats & Trends

Duke’s offense has thrown for 20 or more yards on 14.6% of 254 attempts this season — 12th-best among FBS offenses. Clemson’s defense allowed 20+ yards on just 5.6% of attempts this season — T-6th-best among FBS defenses.

Duke’s WRs has 343 receptions in 20 games (17.2 per game) since the 2024 season — T-7th-best among FBS WRs. Clemson’s defense has allowed 19.8 receptions per game since the 2024 season — T-31st-worst among FBS defenses.

Duke’s offense has thrown for 20 or more yards on 14.6% of 254 attempts this season — 12th-best among FBS offenses. Clemson’s defense allowed 20+ yards on just 5.6% of attempts this season — 2nd-best among ACC defenses.

Duke’s TEs has 20 receptions in 7 games (just 2.9 per game) this season — 4th-worst among ACC TEs. Clemson’s defense has allowed 4.3 receptions per game to TEs this season — T-21st-worst among FBS defenses.

Duke RBs have averaged 9.5 Yards per Carry (409 yards/43 carries) in the 4th quarter this season– best among FBS Teams; Average: 4.9

Clemson Offensive Stats & Trends

Clemson was undefeated (7-0) when allowing less than 5 yards per rush last season– T-best among Power Conference Teams; Average: .647

Clemson was 5-2 (.714) when their opponent rushed more than 30 times last season– 15th-best among Power Conference Teams; Average: .481

Clemson was 10-2 (.833) when making 5 or more explosive passes in a game last season– T-9th-best among Power Conference Teams; Average: .631

Clemson was 8-2 (.800) when allowing less than 50% of third down conversion opportunities last season– T-27th-best in FBS; Average: .602

Duke Defensive Stats & Trends

Duke’s offense has thrown for 20 or more yards on 14.6% of 254 attempts this season — 12th-best among FBS offenses. Clemson’s defense allowed 20+ yards on just 5.6% of attempts this season — T-6th-best among FBS defenses.

Duke’s WRs has 343 receptions in 20 games (17.2 per game) since the 2024 season — T-7th-best among FBS WRs. Clemson’s defense has allowed 19.8 receptions per game since the 2024 season — T-31st-worst among FBS defenses.

Duke’s offense has thrown for 20 or more yards on 14.6% of 254 attempts this season — 12th-best among FBS offenses. Clemson’s defense allowed 20+ yards on just 5.6% of attempts this season — 2nd-best among ACC defenses.

Duke’s TEs has 20 receptions in 7 games (just 2.9 per game) this season — 4th-worst among ACC TEs. Clemson’s defense has allowed 4.3 receptions per game to TEs this season — T-21st-worst among FBS defenses.

Duke RBs have averaged 9.5 Yards per Carry (409 yards/43 carries) in the 4th quarter this season– best among FBS Teams; Average: 4.9

Clemson Defensive Stats & Trends

Clemson was undefeated (7-0) when allowing less than 5 yards per rush last season– T-best among Power Conference Teams; Average: .647

Clemson was 5-2 (.714) when their opponent rushed more than 30 times last season– 15th-best among Power Conference Teams; Average: .481

Clemson was 10-2 (.833) when making 5 or more explosive passes in a game last season– T-9th-best among Power Conference Teams; Average: .631

Clemson was 8-2 (.800) when allowing less than 50% of third down conversion opportunities last season– T-27th-best in FBS; Average: .602

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