Duke vs Illinois Prediction, Odds & Best Prop Bets – NCAAF, Week 2

Illinois head coach Bret Bielema watches from the sideline during the second half of an NCAA college football game against Iowa, Saturday, Nov. 18, 2023, in Iowa City, Iowa. Iowa won 15-13. (AP Photo/Charlie Neibergall)
(AP Photo/Charlie Neibergall)
Odds Boost This Weekend
  • Illinois Fighting Illini is a -6 point favorite vs. Duke Blue Devils
  • Duke vs. Illinois Total (Over/Under): 51.5 points
  • TV Channel: FS1

Duke (1-0) visit Gies Memorial Stadium to take on Illinois (1-0) on Sep. 12 in Champaign, IL. Kickoff is scheduled for 3:30 pm.

The Illinois Fighting Illini are betting favorites in Week 2, with the spread sitting at -6 (-108).

The Duke vs. Illinois Over/Under is 51.5 total points.

Bet now on Illinois Fighting Illini vs Duke Blue Devils & all NCAAF games with BetMGM

Duke vs. Illinois Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Duke+6 -11051.5 -110+188
Illinois -6 -10851.5 -108-225

Duke vs Illinois Prediction:

The winning team model predicts Illinois will win this game with 63.6% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the Duke Blue Devils and the Illinois Fighting Illini, key player performances this season and recent team trends.

Duke vs Illinois Spread Prediction:

Based on recent against-the-spread trends, the model predicts Illinois will cover the spread with 60.9% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on Illinois Fighting Illini vs Duke Blue Devils and all games with BetMGM


  • Duke has hit the 1Q Game Total Over in 5 of their last 7 away games (+3.95 Units / 48% ROI)
  • Duke have covered the 1H Spread in 5 of their last 6 away games (+3.85 Units / 57% ROI)
  • Duke has hit the Moneyline in 5 of their last 6 away games (+3.15 Units / 29% ROI)
  • Duke has hit the 1H Moneyline in 8 of their last 13 games (+2.95 Units / 14% ROI)
  • Duke has hit the Game Total Over in 4 of their last 5 away games (+2.90 Units / 52% ROI)
  • Illinois has hit the Moneyline in 7 of their last 8 games at home (+7.20 Units / 8% ROI)
  • Illinois has hit the 1H Moneyline in 7 of their last 8 games at home (+6.50 Units / 12% ROI)
  • Illinois has hit the Game Total Under in 6 of their last 8 games at home (+3.80 Units / 43% ROI)
  • Illinois has hit the 1H Game Total Under in 6 of their last 8 games at home (+3.70 Units / 40% ROI)
  • Illinois has hit the Team Total Under in 8 of their last 12 games (+3.40 Units / 25% ROI)

Duke Against the Spread (ATS) Record

Duke Blue Devils is 1-0 against the spread this college football season (+1 Units / 90.91% ROI).

  • Duke is 1-0 when betting on the Moneyline for +1 Units / 26.32% ROI
  • Duke is 0-1 when betting the Over for -1.1 Units / -100% ROI
  • Duke is 1-0 when betting the Under for +1 Units / 90.91% ROI

Illinois Against the Spread (ATS) Record

Illinois Fighting Illini is 0-1 against the spread this college football season (-1.1 Units / -100% ROI).

  • Illinois is 1-0 when betting on the Moneyline for +1 Units / 3.33% ROI
  • Illinois is 1-0 when betting the Over for +1 Units / 90.91% ROI
  • Illinois is 0-1 when betting the Under for -1.1 Units / -100% ROI

Duke: Keys to the Game vs. Illinois

Duke was 8-4 (.667) when their opponent rushed more than 30 times last season– T-24th-best in FBS; Average: .442

Duke was 8-1 (.889) when allowing less than 50% of third down conversion opportunities last season– T-7th-best among Power Conference Teams; Average: .645

Duke was 9-3 (.750) when allowing less than 5 yards per rush last season– T-36th-best in FBS; Average: .632

Duke was 6-1 (.857) when rushing at least 4 yards in a play 10 or more times last season– 9th-best among Power Conference Teams; Average: .618

Illinois: Keys to the Game vs. Duke

Illinois was 10-2 (.833) when rushing at least 4 yards in a play 10 or more times last season– 12th-best among Power Conference Teams; Average: .618

Illinois was 9-1 (.900) when converting 55% or more of its red zone chances into touchdowns last season– 6th-best among Power Conference Teams; Average: .657

Illinois was 9-2 (.818) when averaging more than 5 yards on first down plays last season– T-10th-best among Power Conference Teams; Average: .632

Illinois was 10-2 (.833) when rushing at least 4 yards in a play 10 or more times last season– T-15th-best in FBS; Average: .575

Matchup Notes for Duke vs. Illinois

Illinois’s RBs averaged 9.2 yards after the catch last season — T-32nd-best among FBS RBs. Duke’s defense allowed 12.2 RAC last season — 2nd-worst among ACC defenses.

Illinois’s TEs had 38 receptions in 13 games (just 2.9 per game) last season — T-4th-worst among Big Ten TEs. Duke’s defense allowed 22.2 receptions per game last season — 5th-worst among ACC defenses.

Illinois’s RBs averaged 9.2 yards after the catch last season — T-32nd-best among FBS RBs. Duke’s defense allowed 12.2 RAC last season — T-28th-worst among FBS defenses.

Duke’s QBs threw for 3,995 passing yards in 14 games (285.4 YPG) last season — 11th-best among FBS teams. Illinois’s defense allowed 218.4 passing yards per game last season — 5th-worst among Big Ten defenses.

Duke’s offense threw for 3,995 passing yards in 14 games (285.4 YPG) last season — 12th-best among FBS offenses. Illinois’s defense allowed 218.4 passing yards per game last season — 5th-worst among Big Ten defenses.

Duke’s TEs gained 677 yards on 57 receptions (11.9 YPR) last season — 3rd-best among ACC TEs. Illinois’s defense allowed just 10.4 Yards Per Reception last season — T-16th-best among FBS defenses.

Duke Offensive Stats & Trends

Duke’s QBs threw for 3,995 passing yards in 14 games (285.4 YPG) last season — 11th-best among FBS teams. Illinois’s defense allowed 218.4 passing yards per game last season — 5th-worst among Big Ten defenses.

Duke threw 5.7 Passing TDs per Interception (34 passing TDs/6 interceptions) last season– 6th-best among FBS Offenses; Average: 2.0

Duke’s offense threw for 3,995 passing yards in 14 games (285.4 YPG) last season — 12th-best among FBS offenses. Illinois’s defense allowed 218.4 passing yards per game last season — 5th-worst among Big Ten defenses.

Duke threw 6 interceptions on 506 attempts (1 INT per 84.3 attempts) last season– 6th-best among FBS Offenses; Average: 40.1

Duke’s TEs gained 677 yards on 57 receptions (11.9 YPR) last season — 3rd-best among ACC TEs. Illinois’s defense allowed just 10.4 Yards Per Reception last season — T-16th-best among FBS defenses.

Illinois Offensive Stats & Trends

Illinois TEs averaged 18.0 yards per reception (36 yards/2 catches) in the 4th quarter last season– best among Big Ten Teams; Average: 10.1

Illinois’s RBs averaged 9.2 yards after the catch last season — T-32nd-best among FBS RBs. Duke’s defense allowed 12.2 RAC last season — 2nd-worst among ACC defenses.

Illinois’s TEs had 38 receptions in 13 games (just 2.9 per game) last season — T-4th-worst among Big Ten TEs. Duke’s defense allowed 22.2 receptions per game last season — 5th-worst among ACC defenses.

Illinois RBs averaged 8.2 yards from scrimmage per touch (172 yards / 21 touches) on 3rd and short last season– T-4th-best among FBS Teams; Average: 4.4

Illinois’s RBs averaged 9.2 yards after the catch last season — T-32nd-best among FBS RBs. Duke’s defense allowed 12.2 RAC last season — T-28th-worst among FBS defenses.

Duke Defensive Stats & Trends

Duke allowed 57 receptions for 20+ yards last season– most among Power Conference Teams

Duke had no interceptions (0 pass attempts) in the Red Zone last season– T-worst among Power Conference Teams; Average: 31.3

Duke defense allowed 57 completions for 20 or more yards last season– most in FBS

Duke had no interceptions (0 pass attempts) in the Red Zone last season– T-worst in FBS; Average: 31.0

Duke allowed 3,875 Passing Yards last season– most in FBS

Illinois Defensive Stats & Trends

Illinois had no interceptions and 17 TD passes allowed in the Red Zone last season– T-worst in the Big Ten; Average: 10.7

Illinois tackled opponents for a loss on just 3 of 67 rushing attempts (4% TFL%) in the Red Zone last season– worst among Power Conference Teams; Average: 15%.

Illinois allowed passes of 20+ yards on just 26 of 429 attempts (6%) last season– 2nd-best among Power Conference Teams; Average: 9%

Illinois allowed 17 TD passes in the Red Zone last season– T-most among Power Conference Teams

Illinois had no interceptions (0 pass attempts) in the Red Zone last season– T-worst in FBS; Average: 31.0


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