Iowa St vs Colorado Prediction, Odds & Best Prop Bets – NCAAF, Week 7

BetMGM Betting Oct 10, 2025, 11:18 AM

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Colorado head coach Deion Sanders in the first half of the team's spring practice NCAA college football game Saturday, April 22, 2023, in Boulder, Colo.

(AP Photo/David Zalubowski)

Iowa St is a -3 point favorite vs. Colorado
Iowa State vs. Colorado Total (Over/Under): 51.5 points
TV Channel: ESPN

Iowa State (5-1) visit Folsom Field to take on Colorado (2-4) on Oct. 11 in Boulder, CO. Kickoff is scheduled for 3:30pm EDT.

Iowa St is a betting favorite in Week 7, with the spread sitting at -3 (-105).

The Iowa State vs. Colorado Over/Under is 51.5 total points.

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Iowa State vs. Colorado Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Iowa State	-3 -105	51.5 -105	-145
Colorado	+3 -115	51.5 -115	120

Iowa State vs Colorado Prediction:

The winning team model predicts Iowa State will win this game with 60.0% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Iowa St and Colorado, key player performances this season and recent team trends.

Iowa State vs Colorado Spread Prediction:

Based on recent against-the-spread trends, the model predicts Colorado will cover the spread with 55.1% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Iowa State Best Bets Today

Iowa State has hit the 1H Game Total Over in 10 of their last 15 games (+4.30 Units / 25% ROI)
Iowa State has hit the 1Q Game Total Over in 9 of their last 15 games (+3.45 Units / 20% ROI)
Iowa State has hit the Moneyline in 11 of their last 15 games (+3.30 Units / 7% ROI)
Iowa State has hit the Game Total Over in 5 of their last 8 away games (+1.70 Units / 19% ROI)
Iowa State has hit the 1Q Moneyline in 8 of their last 13 games (+1.05 Units / 4% ROI)

Colorado Best Bets Today

Colorado has hit the 1Q Moneyline in 6 of their last 8 games at home (+4.95 Units / 25% ROI)
Colorado have covered the Spread in 7 of their last 9 games at home (+4.80 Units / 48% ROI)
Colorado have covered the 1Q Spread in 6 of their last 9 games at home (+3.90 Units / 38% ROI)
Colorado has hit the 1H Moneyline in 6 of their last 9 games at home (+3.10 Units / 9% ROI)
Colorado has hit the Game Total Under in 8 of their last 14 games (+2.50 Units / 16% ROI)

Iowa State Against the Spread (ATS) Record

Iowa St is 3-2 against the spread this college football season (+0.8 Units / 12.12% ROI).

Iowa State is 5-1 when betting on the Moneyline for +4.3 Units / 15.38% ROI
Iowa State is 3-3 when betting the Over for -0.3 Units / -4.55% ROI
Iowa State is 3-3 when betting the Under for -0.3 Units / -4.55% ROI

Colorado Against the Spread (ATS) Record

Colorado iss 3-3 against the spread this college football season (-0.3 Units / -4.55% ROI).

Colorado is 2-4 when betting on the Moneyline for -2 Units / -6.58% ROI
Colorado is 2-4 when betting the Over for -2.4 Units / -36.36% ROI
Colorado is 4-2 when betting the Under for +1.8 Units / 27.27% ROI

Iowa State: Keys to the Game vs. Colorado

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among FBS Teams; Average: 12.3

Colorado WRs averaged 23.3 receptions per game (303/13) last season– best among Power Conference Teams; Average: 12.6

Colorado’s WRs has 381 receptions in 19 games (20.1 per game) since the 2024 season — best among Power 5 WRs. Iowa State’s defense has allowed just 15.4 receptions per game since the 2024 season — best among Big 12 defenses.

Colorado TEs have no receptions on 1 targets on 3rd and long since the 2024 season– worst among Big 12 Teams; Average: 56%

Colorado: Keys to the Game vs. Iowa State

Iowa State has allowed passes of 20+ yards on 6 of 25 attempts (24%) on 3rd and long this season– worst in the Big 12; Average: 9%

Iowa State allowed rushes of 10 or more yards on 13 of 34 carries (38%) last week– worst in the Big 12; Average: 15%

Iowa State allowed rushes of 10 or more yards on 13 of 34 carries (38%) last week– worst among Power Conference Teams; Average: 12%

Iowa State has allowed passes of 20+ yards on 6 of 25 attempts (24%) on 3rd and long this season– worst among Power Conference Teams; Average: 8%

Iowa State allowed a Completion Pct of just 35% (12 completions/34 attempts) in close and late situations last season– best among Power Conference Teams; Average: 59%

Matchup Notes for Iowa State vs. Colorado