- – (3-6) are point favorites vs – (3-6)
- Total (Over/Under): points
- Watch the game on ESPNU
The James Madison Dukes (5-3) visit Cardinal Stadium to take on the Louisville Cardinals (6-3) on Nov. 5. Kickoff is scheduled for 7:30pm EST in Louisville.
– are betting favorites in Week 10, with the spread sitting at ().
The Over/Under for James Madison vs. Louisville is total points.
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James Madison vs. Louisville Odds, Spread, Over/Under for Week 10
| Spread | Total (O/U) | Moneyline | |
| James Madison | |||
| Louisville |
James Madison vs Louisville Prediction for Week 10
Based on recent trends, the winning team model predicts
James Madison vs Louisville Spread Prediction for Week 10
Based on recent against-the-spread trends, the model predicts
Both predictions factor in up-to-date player injuries for both James Madison and Louisville, plus offensive & defensive matchups, recent games and key player performances this season.
Best James Madison Player Prop Bets Today
We’ve highlighted some favorite college football player prop bets for James Madison players for Week 10, looking at profitable historical betting trends:
player high – away
Best Louisville Player Prop Best Bets Today
Top NCAAF player prop bets for Louisville players for Week 10, looking at profitable historical betting trends:
player high – home
James Madison Best Bets & Trends for ATS, Moneyline & Totals
team high – away
Louisville Best Bets & Trends for ATS, Moneyline & Totals
team high – home
James Madison Against the Spread (ATS) Record
James Madison has gone against the spread this college football season ( Units / ROI).
- James Madison is when betting on the Moneyline for Units / ROI
- James Madison is when betting the Over for Units / ROI
- James Madison is when betting the Under for Units / ROI
Louisville Against the Spread (ATS) Record
Louisville has gone against the spread this college football season ( Units / ROI).
- Louisville is when betting on the Moneyline for Units / ROI
- Louisville is when betting the Over for Units / ROI
- Louisville is when betting the Under for Units / ROI
James Madison: Keys to the Game vs. Louisville
James Madison is winless (0-1) when not forcing a fumble — tied for worst in FBS; Average: .441
James Madison is winless (0-2) when allowing 100 or more rushing yards — tied for worst in FBS; Average: .395
James Madison is winless (0-3) when allowing 22 or more points — tied for worst in FBS; Average: .284
Louisville: Keys to the Game vs. James Madison
Louisville is 2-12 (.143) when allowing 5 or more explosive passes since the 2020 season– 3rd-worst among Power 5 Teams; Average: .450
Louisville is 2-15 (.118) when allowing 22 or more points since the 2020 season– tied for 7th-worst among Power 5 Teams; Average: .302
Louisville is 3-12 (.167) when converting less than 50% of third down conversion opportunities since the 2020 season– tied for 7th-worst among Power 5 Teams; Average: .361
Louisville is 4-13 (.235) when allowing 200 or more passing yards since the 2020 season– 6th-worst among Power 5 Teams; Average: .465
Matchup Notes for James Madison vs. Louisville
Louisville’s QBs has 1,544 rushing yards since the 2021 season — third-most among FBS teams. Clemson’s defense has allowed 2,123 rushing yards since the 2021 season — fewest among ACC defenses.
Louisville’s QBs has 1,544 rushing yards since the 2021 season — third-most among FBS teams. Clemson’s defense has allowed 2,123 rushing yards since the 2021 season — fourth-fewest among FBS defenses.
Louisville’s QBs has 22 rushing touchdowns in the Red Zone since the 2021 season — most among FBS teams. Clemson’s defense has allowed 14 rushing TDs since the 2021 season — tied for second-fewest among P5 defenses.
There are no matchup notes available for this game
James Madison Offensive Stats & Trends
James Madison WRs have averaged 23.0 yards per reception (299 yards/13 catches) in the 4th quarter since last season– best among FBS Teams; Average: 13.4
James Madison Skill Players have been targeted 153 times since last season– fewest among FBS Teams
James Madison WRs have averaged 18.0 yards per reception (971 yards/54 catches) since last season– 2nd best among FBS Teams; Average: 13.3
James Madison Skill Players have averaged 18.8 yards per reception (169 yards/9 catches) with 4-6 yards to go since last season– 2nd best among FBS Teams; Average: 11.4
James Madison Skill Players have caught just 7 of 24 passes (29% Reception Pct) on 3rd and long since last season– worst among FBS Teams; Average: 57%
Louisville Offensive Stats & Trends
Louisville QBs have rushed for 29 TDs since last season– most among FBS Teams
Louisville QBs have rushed for 10 TDs in the 1st quarter since last season– most among FBS Teams
Louisville QBs have rushed for 22 TDs in the Red Zone since last season– most among FBS Teams
Louisville QBs have averaged 73.5 rushing yards per game (1,544/21) since last season– 3rd best among FBS Teams; Average: 24.2
Louisville’s QBs has 1,544 rushing yards since the 2021 season — third-most among FBS teams. Clemson’s defense has allowed 2,123 rushing yards since the 2021 season — fewest among ACC defenses.
James Madison Dukes Defensive Stats & Trends
James Madison has tackled opponents for a loss on 8 of 21 rushing attempts (38% TFL%) in the Red Zone since last season– best in FBS; Average: 15%.
James Madison has tackled opponents for a loss on 8 of 21 rushing attempts (38% TFL%) in the Red Zone since last season– best among Non-Power 5 Teams; Average: 15%.
James Madison has tackled opponents for a loss on 39 of 165 rushing attempts (24% TFL%) since last season– best among Non-Power 5 Teams; Average: 16%.
James Madison has allowed passes of 20+ yards on 6 of 24 attempts (25%) on 3rd and long since last season– best in FBS; Average: 10%
James Madison has tackled opponents for a loss on 2 of 7 rushing attempts (29% TFL%) on 3rd and short since last season– best among Non-Power 5 Teams; Average: 11%.
Louisville Cardinals Defensive Stats & Trends
Louisville has sacked opposing QBs on 12% of pass attempts (28/230) this season– 5th best in FBS; Average: 7%
Louisville has sacked opposing QBs on 12% of pass attempts (28/230) this season– 2nd best among Power 5 Teams; Average: 7%
Louisville has allowed opponents to rush for 20+ yards on 17 of their 294 carries (6%) this season– 3rd worst among Power 5 Teams; Average: 3%
Louisville has intercepted 3 of 26 attempts (8.7 pass attempts per int.) in the Red Zone this season– tied for best among Power 5 Teams; Average: 33.8
Louisville has averaged 1.50 interceptions per game (12/8) this season– tied for 5th best in FBS; Average: 0.84
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