Louisiana vs USC Prediction, Odds & Best Prop Bets – NCAAF, Week 2

Southern California head coach Lincoln Riley watches during the first half of an NCAA college football game against Utah, Saturday, Oct. 21, 2023, in Los Angeles. (AP Photo/Ryan Sun)
(AP Photo/Ryan Sun)
Sportsbook Promos This Week
  • USC Trojans is a -30.5 point favorite vs. Louisiana-Lafayette Ragin Cajuns
  • Louisiana vs. USC Total (Over/Under): 59.5 points
  • TV Channel: BTN

Louisiana (1-0) visit Los Angeles Memorial Coliseum to take on USC (2-0) on Sep. 12 in Los Angeles, CA. Kickoff is scheduled for 11:00 pm.

The USC Trojans are betting favorites in Week 2, with the spread sitting at -30.5 (-110).

The Louisiana vs. USC Over/Under is 59.5 total points.

Bet now on USC Trojans vs Louisiana-Lafayette Ragin Cajuns & all NCAAF games with BetMGM

Louisiana vs. USC Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Louisiana+30.5 -10859.5 -110+2500
USC -30.5 -11059.5 -108-10000

Louisiana vs USC Prediction:

The winning team model predicts USC will win this game with 94.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the Louisiana-Lafayette Ragin Cajuns and the USC Trojans, key player performances this season and recent team trends.

Louisiana vs USC Spread Prediction:

Based on recent against-the-spread trends, the model predicts Louisiana will cover the spread with 64.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on USC Trojans vs Louisiana-Lafayette Ragin Cajuns and all games with BetMGM


  • Louisiana has hit the Team Total Over in 10 of their last 12 games (+7.65 Units / 55% ROI)
  • Louisiana has hit the 1H Game Total Over in 9 of their last 12 games (+5.65 Units / 40% ROI)
  • Louisiana has hit the Game Total Over in 8 of their last 12 games (+3.60 Units / 27% ROI)
  • Louisiana has hit the 1H Moneyline in 2 of their last 5 away games (+2.95 Units / 56% ROI)
  • Louisiana has hit the Moneyline in 2 of their last 3 away games (+1.35 Units / 41% ROI)
  • USC has hit the Moneyline in their last 6 games at home (+6.00 Units / 11% ROI)
  • USC has hit the 1Q Moneyline in 8 of their last 13 games (+4.00 Units / 8% ROI)
  • USC has hit the 1Q Game Total Under in 5 of their last 7 games at home (+2.75 Units / 35% ROI)
  • USC has hit the Team Total Under in 8 of their last 13 games (+2.50 Units / 17% ROI)
  • USC has hit the 1H Game Total Under in 8 of their last 13 games (+2.15 Units / 14% ROI)

Louisiana Against the Spread (ATS) Record

Louisiana-Lafayette Ragin Cajuns is 1-0 against the spread this college football season (+1 Units / 90.91% ROI).

  • Louisiana is 1-0 when betting on the Moneyline for +1 Units / 8.33% ROI
  • Louisiana is 0-1 when betting the Over for -1.1 Units / -100% ROI
  • Louisiana is 1-0 when betting the Under for +1 Units / 90.91% ROI

USC Against the Spread (ATS) Record

USC Trojans is 1-1 against the spread this college football season (-0.1 Units / -4.55% ROI).

  • USC is 1-0 when betting on the Moneyline for +1 Units / 4.55% ROI
  • USC is 1-1 when betting the Over for -0.1 Units / -4.55% ROI
  • USC is 1-1 when betting the Under for -0.1 Units / -4.55% ROI

Louisiana: Keys to the Game vs. USC

Louisiana was 6-4 (.600) when sacking the QB less than 3 times last season– T-30th-best in FBS; Average: .429

Louisiana was 9-2 (.818) when averaging more than 5 yards on first down plays last season– T-11th-best among Non-Power Conference Teams; Average: .570

Louisiana was 7-1 (.875) when they have committed less than 60 yards in penalties last season– T-3rd-best among Non-Power Conference Teams; Average: .470

Louisiana was 9-1 (.900) when converting 55% or more of its red zone chances into touchdowns last season– T-9th-best in FBS; Average: .624

USC: Keys to the Game vs. Louisiana

USC is undefeated (10-0) when not throwing an interception since the 2024 season– T-best in FBS; Average: .699

USC was 2-5 (.250) when not forcing a fumble in the 2023 season– T-11th-worst among Power Conference Teams; Average: .513

USC is 15-6 (.714) when having a turnover margin within one of the opposing team since the 2024 season– T-23rd-best in FBS; Average: .530

USC is 12-5 (.706) when committing less than 60 yards in penalties since the 2024 season– T-20th-best in FBS; Average: .521

Matchup Notes for Louisiana vs. USC

USC’s RBs averaged 9.6 yards after the catch last season — 25th-best among FBS RBs. Louisiana’s defense allowed just 6.3 RAC to RBs last season — T-35th-best among FBS defenses.

USC has gained 4,578 yards on 334 receptions (13.7 YPR) since the 2024 season — T-best among Big Ten skill players. Louisiana’s defense has allowed 12.7 Yards Per Reception to TEs since the 2024 season — T-14th-worst among FBS defenses.

USC has averaged 13.7 yards after the catch since the 2024 season — T-best among Big Ten skill players. Louisiana’s defense has allowed 12.7 RAC to TEs since the 2024 season — T-13th-worst among FBS defenses.

Louisiana’s offense threw for 20 or more yards on just 7.6% of 341 attempts last season — T-16th-worst among FBS offenses. USC’s defense allowed 20+ yards on just 8.1% of attempts last season — 5th-best among Big Ten defenses.

Louisiana’s offense threw for 20 or more yards on just 7.6% of 341 attempts last season — T-16th-worst among FBS offenses. USC’s defense allowed 20+ yards on just 8.1% of attempts last season — T-29th-best among FBS defenses.

Louisiana’s RBs had just 16.5 receiving yards per game last season — 35th-worst among FBS RBs. USC’s defense allowed 29.5 receiving yards per game to RBs last season — 35th-worst among FBS defenses.

Louisiana Offensive Stats & Trends

Louisiana’s offense threw for 20 or more yards on just 7.6% of 341 attempts last season — T-16th-worst among FBS offenses. USC’s defense allowed 20+ yards on just 8.1% of attempts last season — 5th-best among Big Ten defenses.

Louisiana’s offense threw for 20 or more yards on just 7.6% of 341 attempts last season — T-16th-worst among FBS offenses. USC’s defense allowed 20+ yards on just 8.1% of attempts last season — T-29th-best among FBS defenses.

Louisiana QBs rushed for 5 TDs in the 4th quarter last season– T-3rd-most among FBS Teams

Louisiana RBs averaged 5.7 Yards per Carry (2,055 yards/363 carries) last season– T-22nd-best among FBS Teams; Average: 5.1

Louisiana WRs averaged just 8.2 receptions per game (106/13) last season– 16th-worst among FBS Teams; Average: 12.4

USC Offensive Stats & Trends

USC TEs gained no yards on 1 catches (0.0 YPR) on 3rd and long last season– worst among Big Ten Teams; Average: 11.0

USC TEs averaged 17.4 yards per reception (365 yards/21 catches) on 1st down last season– best among Big Ten Teams; Average: 11.0

USC TEs had no touchdowns on 5 receptions in the Red Zone last season– T-worst Receptions Per TD among Big Ten Teams; Average: 2.3

USC WRs caught 9 touchdown passes in the 4th quarter last season– most among Big Ten Teams

USC TEs had no touchdowns on 33 receptions last season– T-worst Receptions Per TD among FBS Teams; Average: 9.6

Louisiana Defensive Stats & Trends

Louisiana allowed 7 TD passes in close and late situations last season– T-3rd-most in FBS

Louisiana allowed 11 TD passes in close and late situations in the 2023 season– most among Non-Power Conference Teams

Louisiana tackled opponents for a loss on just 64 of 516 rushing attempts (12% TFL%) last season– T-19th-worst in FBS; Average: 15%.

Louisiana allowed a Completion Pct of just 25% (5 completions/20 attempts) on third and 10+ yards to go in the 2023 season– best in FBS; Average: 55%

Louisiana allowed passes of 40+ yards on just 3 of 429 attempts (1%) last season– best among Non-Power Conference Teams; Average: 2%

USC Defensive Stats & Trends

USC tackled opponents for a loss on just 4 of 68 rushing attempts (6% TFL%) in the Red Zone last season– 6th-worst in FBS; Average: 14%.

USC tackled opponents for a loss on just 49 of 403 rushing attempts (12% TFL%) last season– 5th-worst among Power Conference Teams; Average: 16%.

USC allowed a Completion Pct of 100% (9 completions/9 attempts) on 3rd and short in the 2023 season– worst in the Big Ten; Average: 60%

USC allowed a Completion Pct of 68% (296 completions/436 attempts) last season– worst in the Big Ten; Average: 61%

USC had no interceptions and 16 TD passes allowed in the Red Zone in the 2023 season– T-worst in the Big Ten; Average: 12.5


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