- Louisville is a -10 point favorite vs. Indiana
- Total (Over/Under): 52.5 points
- Watch the game on BTN
The Louisville Cardinals visit Lucas Oil Stadium to take on the Indiana Hoosiers on Sep. 16. Kickoff is scheduled for 12:00pm EDT in Indianapolis.
Louisville is a betting favorite in Week 3, with the spread sitting at -10 (-110).
The Louisville vs. Indiana Over/Under is 50.5 total points.
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Louisville vs. Indiana Odds, Spread, Over/Under for Week 3
| Spread | Total (O/U) | Moneyline | |
| Louisville | -10 -110 | 50.5 -110 | -375 |
| Indiana | +10 -110 | 50.5 -110 | +280 |
Louisville vs Indiana Prediction for Week 3
Based on recent trends, the winning team model predicts Louisville will win this game with 63.4% confidence.
Louisville vs Indiana Spread Prediction for Week 3
Based on recent against-the-spread trends, the model predicts Indiana will cover the spread with 53.3% confidence.
Both predictions factor in up-to-date player injuries for both Louisville and Indiana, plus offensive & defensive matchups, recent games and key player performances this season.
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Louisville Best Bets & Trends for ATS, Moneyline & Totals
- Louisville has hit the 1Q Game Total Under in their last 7 games (+7.00 Units / 82% ROI)
- Louisville has hit the 1H Game Total Under in 7 of their last 8 games (+5.90 Units / 66% ROI)
- Louisville has hit the 1H Moneyline in 6 of their last 11 games (+3.10 Units / 16% ROI)
- Louisville has hit the Team Total Over in 6 of their last 9 games (+2.60 Units / 25% ROI)
- Louisville have covered the Spread in 8 of their last 13 games (+2.50 Units / 17% ROI)
Indiana Best Bets & Trends for ATS, Moneyline & Totals
- Indiana has hit the 1Q Moneyline in their last 4 games (+4.80 Units / 120% ROI)
- Indiana have covered the 1H Spread in 6 of their last 8 games (+3.85 Units / 45% ROI)
- Indiana has hit the 1H Moneyline in 3 of their last 5 games (+3.55 Units / 71% ROI)
- Indiana have covered the 1Q Spread in 5 of their last 7 games (+3.00 Units / 27% ROI)
- Indiana has hit the 1H Game Total Under in 4 of their last 5 games at home (+2.90 Units / 53% ROI)
Best Louisville Player Prop Bets Today
We’ve highlighted some favorite college football player prop bets for Louisville players for Week 3, looking at profitable historical betting trends:
- Ahmari Huggins-Bruce has hit the Receiving Yards Under in 5 of his last 6 games (+3.80 Units / 52% ROI)
Louisville Against the Spread (ATS) Record
Louisville is 1-1 against the spread this college football season (-0.1 Units / -4.55% ROI).
- Louisville is 1-0 when betting on the Moneyline for +1 Units / 33.33% ROI
- Louisville is 2-0 when betting the Over for +2 Units / 90.91% ROI
- Louisville is 0-2 when betting the Under for -2.2 Units / -100% ROI
Indiana Against the Spread (ATS) Record
Indiana is 2-0 against the spread this college football season (+2 Units / 90.91% ROI).
- Indiana is 2-7 when betting on the Moneyline for -2.35 Units / -22.17% ROI
- Indiana is 1-1 when betting the Over for -0.1 Units / -4.55% ROI
- Indiana is 1-1 when betting the Under for -0.1 Units / -4.55% ROI
Louisville: Keys to the Game vs. Indiana
Louisville is 8-4 (.571) when not losing a fumble since the 2021 season– 15th-best among Power 5 Teams; Average: .423
Louisville is 4-1 (.667) when not losing a fumble since the 2022 season– tied for 7th-best among Power 5 Teams; Average: .398
Louisville is 8-3 (.727) when forcing at least one fumble since the 2021 season– tied for 15th-best among Power 5 Teams; Average: .570
Louisville is undefeated (2-0) when converting more than 50% of third down conversions since the 2021 season– tied for 7th-best among Power 5 Teams; Average: .435
Indiana: Keys to the Game vs. Louisville
Indiana is 1-15 (.062) when not forcing a fumble since the 2021 season– 2nd-worst among Power 5 Teams; Average: .452
Indiana is 1-10 (.091) when the opposing team commits less than 60 yards in penalties since the 2021 season– tied for 3rd-worst among Power 5 Teams; Average: .513
Indiana is 1-16 (.053) when converting less than 50% of third down conversion opportunities since the 2021 season– 3rd-worst among Power 5 Teams; Average: .356
Indiana is 3-15 (.143) when rushing more than 30 times since the 2021 season– tied for 5th-worst in FBS; Average: .520
Matchup Notes for Louisville vs. Indiana
Indiana’s TEs has 3 receptions in 2 games (just 1.5 per game) this season — tied for worst among Big Ten TEs. Louisville’s defense has allowed just 13.5 receptions per game this season — third-best among ACC defenses.
Indiana’s TEs has 3 receptions in 2 games (just 1.5 per game) this season — tied for worst among Big Ten TEs. Louisville’s defense has allowed just 13.5 receptions per game this season — tied for 20th-best among FBS defenses.
Indiana’s RBs have 41.6 receiving yards per game since the 2022 season — tied for 13th-best among FBS RBs. Louisville’s defense has allowed just 196.5 receiving yards per game since the 2022 season — 27th-best among FBS defenses.
Louisville’s QBs has thrown for 3,287 passing yards in 15 games (just 219.1 YPG) since the 2022 season — 31st-worst among FBS teams. Indiana’s defense has allowed 266.7 passing yards per game since the 2022 season — 26th-worst among FBS defenses.
Louisville’s TEs has 1 receptions in 2 games (just 0.5 per game) this season — tied for worst among ACC TEs. Indiana’s defense has allowed just 12.0 receptions per game this season — third-best among Big Ten defenses.
Louisville’s TEs has 1 receptions in 2 games (just 0.5 per game) this season — tied for worst among ACC TEs. Indiana’s defense has allowed just 12.0 receptions per game this season — tied for ninth-best among FBS defenses.
Louisville Offensive Stats & Trends
Louisville’s QBs has thrown for 3,287 passing yards in 15 games (just 219.1 YPG) since the 2022 season — 31st-worst among FBS teams. Indiana’s defense has allowed 266.7 passing yards per game since the 2022 season — 26th-worst among FBS defenses.
Louisville’s TEs has 1 receptions in 2 games (just 0.5 per game) this season — tied for worst among ACC TEs. Indiana’s defense has allowed just 12.0 receptions per game this season — third-best among Big Ten defenses.
Louisville’s TEs has 1 receptions in 2 games (just 0.5 per game) this season — tied for worst among ACC TEs. Indiana’s defense has allowed just 12.0 receptions per game this season — tied for ninth-best among FBS defenses.
Louisville’s offense has thrown for 20 or more yards on 16.9% of 65 attempts this season — 20th-best among FBS offenses. Indiana’s defense allowed 20+ yards on just 6.4% of attempts this season — 34th-worst among FBS defenses.
Louisville’s TEs has 1 receptions in 2 games (just 0.5 per game) this season — tied for worst among P5 TEs. Indiana’s defense has allowed just 12.0 receptions per game this season — tied for ninth-best among FBS defenses.
Indiana Offensive Stats & Trends
Indiana WRs have averaged a touchdown every 29.2 receptions (292 Rec/10 TDs) since the 2021 season– 2nd worst Receptions Per TD among FBS Teams; Average: 10.7
Indiana Skill Players fumbled 6 times in the 4th quarter in the 2022 season– most among Power 5 Teams
Indiana Skill Players fumbled 5 times in close and late situations in the 2022 season– tied for most among FBS Teams
Indiana WRs have averaged a touchdown every 26.1 receptions (183 Rec/7 TDs) since last season– 3rd worst Receptions Per TD among Power 5 Teams; Average: 10.5
Indiana Skill Players have fumbled 8 times in close and late situations since the 2021 season– tied for 2nd most among FBS Teams
Louisville Cardinals Defensive Stats & Trends
Louisville has allowed a passer rating of 306.3 in the Red Zone (3.0 Pass Attempts) since the 2021 season– worst among Power 5 Teams; Average: 164.1
Louisville has allowed a Completion Pct of just 23% (4 completions/17 attempts) when opponents had over 10 yards to go since the 2021 season– best among Power 5 Teams; Average: 59%
Louisville has allowed a passer rating of 306.3 in the Red Zone (3.0 Pass Attempts) since last season– worst among Power 5 Teams; Average: 162.9
Louisville has allowed a Completion Pct of just 49% (47 completions/96 attempts) since the 2021 season– 2nd best among Power 5 Teams; Average: 61%
Louisville has sacked opposing QBs on 12% of pass attempts (48/415) since last season– 2nd best in FBS; Average: 7%
Indiana Hoosiers Defensive Stats & Trends
Indiana allowed 17 first down receptions in the Red Zone in the 2022 season– tied for most in FBS
Indiana allowed 17 first down receptions in the Red Zone in the 2022 season– tied for most among Power 5 Teams
Indiana has allowed 39 first down receptions in the Red Zone since the 2021 season– most in FBS
Indiana has allowed 21 first down receptions in the Red Zone since last season– tied for 2nd most in FBS
Indiana has not recorded a sack (36 pass attempts) this season– tied for worst in FBS; Average: 15.4
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