Louisville vs Ole Miss Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 1

Mississippi head coach Pete Golding walks the sideline against Georgia during the second half of the Sugar Bowl NCAA college football playoff quarterfinal game, Thursday, Jan. 1, 2026, in New Orleans. (AP Photo/Matthew Hinton Hinton)
(AP Photo/Matthew Hinton Hinton)
CFB Odds Boost Today
  • Ole Miss Rebels is a -7 point favorite vs. Louisville Cardinals
  • Louisville vs. Ole Miss Total (Over/Under): 55.5 points
  • TV Channel: ABC

Louisville (0-0) visit Nissan Stadium to take on Ole Miss (0-0) on Sep. 6 in Nashville, TN. Kickoff is scheduled for 7:30 pm.

The Ole Miss Rebels are betting favorites in Week 1, with the spread sitting at -7 (-105).

The Louisville vs. Ole Miss Over/Under is 55.5 total points.

Bet now on Ole Miss Rebels vs Louisville Cardinals & all NCAAF games with BetMGM

Louisville vs. Ole Miss Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Louisville+7 -11555.5 -108+220
Ole Miss -7 -10555.5 -110-275

Louisville vs Ole Miss Prediction:

The winning team model predicts Ole Miss will win this game with 62.4% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Louisville Cardinals and Ole Miss Rebels, key player performances this season and recent team trends.

Louisville vs Ole Miss Spread Prediction:

Based on recent against-the-spread trends, the model predicts Ole Miss will cover the spread with 54.9% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on Ole Miss Rebels vs Louisville Cardinals and all games with BetMGM


  • Louisville has hit the Team Total Under in 6 of their last 7 games (+4.80 Units / 61% ROI)
  • Louisville has hit the Moneyline in 3 of their last 4 away games (+4.40 Units / 60% ROI)
  • Louisville has hit the 1H Game Total Under in 8 of their last 12 games (+3.40 Units / 25% ROI)
  • Louisville has hit the Game Total Under in their last 3 away games (+3.00 Units / 91% ROI)
  • Louisville has hit the 1Q Game Total Over in 3 of their last 4 away games (+2.10 Units / 51% ROI)
  • Ole Miss has hit the Moneyline in 10 of their last 12 games (+9.55 Units / 27% ROI)
  • Ole Miss has hit the 1Q Moneyline in 7 of their last 8 games (+6.75 Units / 43% ROI)
  • Ole Miss has hit the 1H Moneyline in 11 of their last 14 games (+6.45 Units / 6% ROI)
  • Ole Miss has hit the Team Total Over in their last 5 games (+5.00 Units / 83% ROI)
  • Ole Miss have covered the Spread in 8 of their last 12 games (+3.65 Units / 28% ROI)

Louisville: Keys to the Game vs. Ole Miss

Louisville was 9-2 (.818) when allowing less than 5 yards per rush last season– T-21st-best in FBS; Average: .632

Louisville was 6-2 (.750) when sacking the QB less than 3 times last season– T-12th-best in FBS; Average: .429

Louisville was 8-2 (.800) when averaging more than 5 yards on first down plays last season– T-26th-best in FBS; Average: .604

Louisville was 5-1 (.833) when intercepting at least 1 pass last season– T-24th-best in FBS; Average: .668

Ole Miss: Keys to the Game vs. Louisville

Ole Miss was 7-2 (.778) when having a turnover margin within one of the opposing team last season– 14th-best among Power Conference Teams; Average: .578

Ole Miss was 10-3 (.769) when making 7 or more explosive plays last season– 33rd-best in FBS; Average: .628

Ole Miss was 9-2 (.818) when averaging more than 5 yards on first down plays last season– T-20th-best in FBS; Average: .604

Ole Miss was 9-2 (.818) when averaging more than 5 yards on first down plays last season– T-10th-best among Power Conference Teams; Average: .632

Matchup Notes for Louisville vs. Ole Miss

Ole Miss’s TEs gained 783 yards on 54 receptions (14.5 YPR) last season — 2nd-best among SEC TEs. Louisville’s defense allowed just 10.1 Yards Per Reception last season — 2nd-best among ACC defenses.

Ole Miss’s WRs gained 3,679 yards on 248 receptions (14.8 YPR) last season — T-3rd-best among SEC WRs. Louisville’s defense allowed just 10.1 Yards Per Reception last season — 2nd-best among ACC defenses.

Ole Miss’s TEs gained 783 yards on 54 receptions (14.5 YPR) last season — 2nd-best among SEC TEs. Louisville’s defense allowed just 10.1 Yards Per Reception last season — T-5th-best among P5 defenses.

Louisville’s offense threw for 20 or more yards on just 8.0% of 414 attempts last season — 21st-worst among FBS offenses. Ole Miss’s defense allowed 20+ yards on just 7.9% of attempts last season — T-3rd-best among SEC defenses.

Louisville’s offense threw for 20 or more yards on just 8.0% of 414 attempts last season — 21st-worst among FBS offenses. Ole Miss’s defense allowed 20+ yards on just 7.9% of attempts last season — T-23rd-best among FBS defenses.

Louisville’s WRs had just 0.9 receiving touchdowns per game last season — T-4th-worst among ACC WRs. Ole Miss’s defense allowed just 1.1 receiving touchdowns per game last season — T-20th-best among FBS defenses.

Louisville Offensive Stats & Trends

Louisville’s offense threw for 20 or more yards on just 8.0% of 414 attempts last season — 21st-worst among FBS offenses. Ole Miss’s defense allowed 20+ yards on just 7.9% of attempts last season — T-3rd-best among SEC defenses.

Louisville’s offense threw for 20 or more yards on just 8.0% of 414 attempts last season — 21st-worst among FBS offenses. Ole Miss’s defense allowed 20+ yards on just 7.9% of attempts last season — T-23rd-best among FBS defenses.

Louisville RBs fumbled 8 times last season– T-most among FBS Teams

Louisville RBs averaged 10.2 yards from scrimmage per touch (214 yards / 21 touches) on 3rd and short last season– 2nd-best among FBS Teams; Average: 4.5

Louisville RBs averaged 9.1 Yards per Carry (335 yards/37 carries) in close and late situations last season– 2nd-best among FBS Teams; Average: 5.2

Ole Miss Offensive Stats & Trends

Ole Miss Skill Players averaged 20.2 yards per reception (1,053 yards/52 catches) in the 4th quarter last season– best among Power Conference Teams; Average: 11.9

Ole Miss Skill Players averaged 20.2 yards per reception (1,053 yards/52 catches) in the 4th quarter last season– best among FBS Teams; Average: 11.8

Ole Miss QBs had 42 completions for 20 or more yards on 1st down last season– most among FBS Teams

Ole Miss WRs averaged 21.6 yards per reception (801 yards/37 catches) in the 4th quarter last season– best among Power Conference Teams; Average: 13.3

Ole Miss averaged 20.2 yards per completion (1,053 yards/52 completions) in the 4th quarter last season– best among FBS Offenses; Average: 11.7

Louisville Defensive Stats & Trends

Louisville tackled opponents for a loss on just 4 of 61 rushing attempts (7% TFL%) in the Red Zone last season– 4th-worst among Power Conference Teams; Average: 15%.

Louisville allowed passes of 40+ yards on just 2 of 409 attempts (1%) last season– T-2nd-best in FBS; Average: 2%

Louisville allowed just 10.1 yards per completion (2,454 yards/242 completions) last season– T-7th-best in FBS; Average: 11.5

Louisville allowed first downs on 17% of pass attempts in close and late situations last season– 4th-best among Power Conference Teams; Average: 31%

Louisville allowed a Completion Pct of 91% (10 completions/11 attempts) on 3rd and short last season– 4th-worst among Power Conference Teams; Average: 62%

Ole Miss Defensive Stats & Trends

Ole Miss allowed 7 rushing TDs on 456 carries (65.1 Carries Per TD) last season– 2nd-best in FBS; Average: 23.2

Ole Miss tackled opponents for a loss on 112 of 456 rushing attempts (25% TFL%) last season– best in the SEC; Average: 17%.

Ole Miss tackled opponents for a loss on 112 of 456 rushing attempts (25% TFL%) last season– best among Power Conference Teams; Average: 16%.

Ole Miss tackled opponents for a loss on 15 of 51 rushing attempts (29% TFL%) in the Red Zone last season– 2nd-best in FBS; Average: 15%.

Ole Miss tackled opponents for a loss on 112 of 456 rushing attempts (25% TFL%) last season– best in FBS; Average: 16%.


Bet now on Ole Miss Rebels vs Louisville Cardinals and all games with BetMGM


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