Missouri vs Vanderbilt Prediction, Odds & Best Prop Bets – NCAAF, Week 9

BetMGM Betting Oct 24, 2025, 3:14 PM

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Vanderbilt head coach Clark Lea argues a call in the first half of an NCAA college football game against Florida Saturday, Nov. 19, 2022, in Nashville, Tenn.

(AP Photo/Mark Humphrey)

Vanderbilt is a -2.5 point favorite vs. Missouri
Missouri vs. Vanderbilt Total (Over/Under): 52.5 points
TV Channel: ESPN

Missouri (6-1) visit FirstBank Stadium to take on Vanderbilt (6-1) on Oct. 25 in Nashville, TN. Kickoff is scheduled for 3:30pm EDT.

Vanderbilt is a betting favorite in Week 9, with the spread sitting at -2.5 (-115).

The Missouri vs. Vanderbilt Over/Under is 52.5 total points.

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Missouri vs. Vanderbilt Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Missouri	+2.5 -105	52.5 -115	125
Vanderbilt	-2.5 -115	52.5 -105	-150

Missouri vs Vanderbilt Prediction:

The winning team model predicts Vanderbilt will win this game with 61.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Missouri and Vanderbilt, key player performances this season and recent team trends.

Missouri vs Vanderbilt Spread Prediction:

Based on recent against-the-spread trends, the model predicts Vanderbilt will cover the spread with 52.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Missouri Best Bets Today

Missouri have covered the Spread in 9 of their last 13 games (+5.70 Units / 40% ROI)
Missouri has hit the Moneyline in 8 of their last 11 games (+5.35 Units / 9% ROI)
Missouri has hit the 1Q Game Total Over in 8 of their last 13 games (+2.78 Units / 19% ROI)
Missouri has hit the Game Total Over in 8 of their last 13 games (+2.50 Units / 17% ROI)
Missouri has hit the Team Total Under in 3 of their last 5 games (+0.70 Units / 12% ROI)

Vanderbilt Best Bets Today

Vanderbilt has hit the 1Q Moneyline in 7 of their last 11 games (+7.35 Units / 20% ROI)
Vanderbilt have covered the 1Q Spread in 10 of their last 13 games (+6.15 Units / 39% ROI)
Vanderbilt has hit the Team Total Over in 6 of their last 7 games (+4.85 Units / 61% ROI)
Vanderbilt have covered the Spread in 9 of their last 13 games (+4.60 Units / 32% ROI)
Vanderbilt has hit the Moneyline in 7 of their last 12 games (+4.20 Units / 6% ROI)

Missouri Against the Spread (ATS) Record

Missouri is 4-2 against the spread this college football season (+1.8 Units / 23.53% ROI).

Missouri is 4-1 when betting on the Moneyline for +3 Units / 6.3% ROI
Missouri is 4-3 when betting the Over for +0.7 Units / 9.09% ROI
Missouri is 3-4 when betting the Under for -1.4 Units / -18.18% ROI

Vanderbilt Against the Spread (ATS) Record

Vanderbilt iss 5-2 against the spread this college football season (+2.8 Units / 36.36% ROI).

Vanderbilt is 5-1 when betting on the Moneyline for +4.45 Units / 7.04% ROI
Vanderbilt is 4-3 when betting the Over for +0.7 Units / 9.09% ROI
Vanderbilt is 3-4 when betting the Under for -1.4 Units / -18.18% ROI

Missouri: Keys to the Game vs. Vanderbilt

Missouri State was winless (0-1) when converting less than 50% of third down conversion opportunities last season– T-worst in FBS; Average: .454

Missouri State was winless (0-1) when allowing more than 3 explosive runs last season– T-worst in FBS; Average: .414

Missouri State was winless (0-1) when allowing 10 or more rushes of four or more yards last season– T-worst in FBS; Average: .479

Missouri State was winless (0-1) when their opponent rushed more than 30 times last season– T-worst in FBS; Average: .442

Vanderbilt: Keys to the Game vs. Missouri

Missouri State allowed a Completion Pct of 100% (4 completions/4 attempts) on 3rd and long last season– worst in FBS; Average: 55%

Missouri State allowed opponents to catch 4 of 4 passes (100% Reception Pct) on 3rd and long last season– worst in FBS; Average: 55%

Missouri State allowed opponents to catch 4 of 4 passes (100% Reception Pct) on 3rd and long last season– worst among Non-Power Conference Teams; Average: 56%

Missouri State allowed 9.6 yards from scrimmage per touch (48 yards / 5 touches) on 3rd and short last season– worst among Non-Power Conference Teams; Average: 5.0

Missouri State allowed a Completion Pct of 100% (3 completions/3 attempts) on third and 10+ yards to go last season– worst in FBS; Average: 56%

Matchup Notes for Missouri vs. Vanderbilt