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Oklahoma vs South Carolina Prediction, Odds & Best Prop Bets – NCAAF, Week 8

BetMGM Betting Oct 15, 2025, 7:03 PM

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South Carolina head coach Shane Beamer reacts to a call during the second quarter of the Gator Bowl NCAA college football game against Notre Dame on Friday, Dec. 30, 2022, in Jacksonville, Fla. (AP Photo/Gary McCullough)

(AP Photo/Gary McCullough)

Oklahoma is a -5.5 point favorite vs. South Carolina
Oklahoma vs. South Carolina Total (Over/Under): 43.5 points
TV Channel: SECN

Oklahoma (5-1) visit Williams-Brice Stadium to take on South Carolina (3-3) on Oct. 18 in Columbia, SC. Kickoff is scheduled for 12:45pm EDT.

Oklahoma is a betting favorite in Week 8, with the spread sitting at -5.5 (-110).

The Oklahoma vs. South Carolina Over/Under is 43.5 total points.

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Oklahoma vs. South Carolina Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
Oklahoma	-5.5 -110	43.5 -115	-220
South Carolina	+5.5 -110	43.5 -105	180

Oklahoma vs South Carolina Prediction:

The winning team model predicts Oklahoma will win this game with 64.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Oklahoma and South Carolina, key player performances this season and recent team trends.

Oklahoma vs South Carolina Spread Prediction:

Based on recent against-the-spread trends, the model predicts Oklahoma will cover the spread with 50.4% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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Oklahoma Best Bets Today

Oklahoma has hit the 1H Moneyline in 9 of their last 12 games (+13.35 Units / 1% ROI)
Oklahoma has hit the Game Total Under in 9 of their last 13 games (+4.60 Units / 32% ROI)
Oklahoma has hit the 1H Game Total Under in 8 of their last 12 games (+4.45 Units / 32% ROI)
Oklahoma have covered the 1Q Spread in 5 of their last 6 away games (+4.35 Units / 63% ROI)
Oklahoma have covered the 1H Spread in 5 of their last 6 away games (+3.85 Units / 56% ROI)

South Carolina Best Bets Today

South Carolina have covered the 1H Spread in 8 of their last 12 games (+3.40 Units / 25% ROI)
South Carolina has hit the Moneyline in 4 of their last 5 games at home (+2.80 Units / 25% ROI)
South Carolina have covered the Spread in 8 of their last 13 games (+2.50 Units / 18% ROI)
South Carolina has hit the 1H Moneyline in 6 of their last 9 games (+1.85 Units / 11% ROI)
South Carolina has hit the Team Total Under in 4 of their last 6 games (+1.75 Units / 25% ROI)

Oklahoma Against the Spread (ATS) Record

Oklahoma is 3-3 against the spread this college football season (-0.3 Units / -4.55% ROI).

Oklahoma is 3-1 when betting on the Moneyline for +2 Units / 6.64% ROI
Oklahoma is 0-6 when betting the Over for -6.6 Units / -100% ROI
Oklahoma is 6-0 when betting the Under for +6 Units / 90.91% ROI

South Carolina Against the Spread (ATS) Record

South Carolina iss 3-3 against the spread this college football season (-0.3 Units / -4.55% ROI).

South Carolina is 2-3 when betting on the Moneyline for -1.55 Units / -18.9% ROI
South Carolina is 2-4 when betting the Over for -2.4 Units / -36.36% ROI
South Carolina is 4-2 when betting the Under for +1.8 Units / 27.27% ROI

Oklahoma: Keys to the Game vs. South Carolina

Oklahoma was 5-1 (.833) when intercepting at least 1 pass last season– T-12th-best among Power Conference Teams; Average: .688

Oklahoma was 2-4 (.333) when in a one score game last season– T-11th-worst among Power Conference Teams; Average: .514

Oklahoma is winless (0-7) when allowing 22 or more points since the 2024 season– T-worst among Power Conference Teams; Average: .290

Oklahoma is undefeated (7-0) when allowing less than 3 sacks since the 2024 season– T-best among Power Conference Teams; Average: .690

South Carolina: Keys to the Game vs. Oklahoma

Oklahoma has tackled opponents for a loss on 55 of 188 rushing attempts (29% TFL%) this season– best among Power Conference Teams; Average: 16%.

Oklahoma has tackled opponents for a loss on 55 of 188 rushing attempts (29% TFL%) this season– best in FBS; Average: 16%.

Oklahoma opponents has averaged 75.0 Passing Attempts per TD (150 Pass Attempts/2 Passing TDs) this season– 4th-best in FBS; Average: 22.0

Oklahoma has tackled opponents for a loss on 55 of 188 rushing attempts (29% TFL%) this season– best in the SEC; Average: 17%.

Oklahoma has sacked opposing QBs on 15% of pass attempts (22/150) this season– best in FBS; Average: 7%

Matchup Notes for Oklahoma vs. South Carolina