South Carolina vs LSU Prediction, Odds & Best Prop Bets – NCAAF, Week 7

BetMGM Betting Oct 10, 2025, 11:26 AM

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LSU head coach Brian Kelly argues a call during the third quarter of an NCAA college football game against Missouri, Saturday, Oct. 7, 2023, in Columbia, Mo. LSU won 49-39. (AP Photo/L.G. Patterson)

(AP Photo/L.G. Patterson)

LSU is a -9.5 point favorite vs. South Carolina
South Carolina vs. LSU Total (Over/Under): 44.5 points
TV Channel: SECN

South Carolina (3-2) visit Tiger Stadium to take on LSU (4-1) on Oct. 11 in Baton Rouge, LA. Kickoff is scheduled for 7:45pm EDT.

LSU is a betting favorite in Week 7, with the spread sitting at -9.5 (-105).

The South Carolina vs. LSU Over/Under is 44.5 total points.

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South Carolina vs. LSU Odds, Spread, Over/Under:

	Spread	Total (O/U)	Moneyline
South Carolina	+9.5 -115	44.5 -110	275
LSU	-9.5 -105	44.5 -110	-350

South Carolina vs LSU Prediction:

The winning team model predicts LSU will win this game with 74.7% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both South Carolina and LSU, key player performances this season and recent team trends.

South Carolina vs LSU Spread Prediction:

Based on recent against-the-spread trends, the model predicts LSU will cover the spread with 53.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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South Carolina Best Bets Today

South Carolina have covered the Spread in 9 of their last 13 games (+4.60 Units / 32% ROI)
South Carolina have covered the 1H Spread in 5 of their last 6 away games (+3.85 Units / 56% ROI)
South Carolina has hit the 1Q Game Total Under in 4 of their last 6 away games (+2.70 Units / 38% ROI)
South Carolina has hit the 1H Moneyline in 6 of their last 9 games (+1.85 Units / 11% ROI)
South Carolina has hit the 1H Game Total Under in 4 of their last 6 away games (+1.70 Units / 25% ROI)

LSU Best Bets Today

LSU has hit the 1H Game Total Under in 10 of their last 12 games (+7.85 Units / 58% ROI)
LSU has hit the Game Total Under in 9 of their last 12 games (+5.70 Units / 43% ROI)
LSU has hit the Moneyline in 5 of their last 6 games at home (+4.95 Units / 45% ROI)
LSU has hit the 1H Moneyline in 5 of their last 7 games at home (+3.20 Units / 4% ROI)
LSU has hit the Team Total Under in 4 of their last 5 games (+2.92 Units / 52% ROI)

South Carolina Against the Spread (ATS) Record

South Carolina is 3-2 against the spread this college football season (+0.8 Units / 14.55% ROI).

South Carolina is 2-2 when betting on the Moneyline for -0.55 Units / -7.64% ROI
South Carolina is 2-3 when betting the Over for -1.3 Units / -23.64% ROI
South Carolina is 3-2 when betting the Under for +0.8 Units / 14.55% ROI

LSU Against the Spread (ATS) Record

LSU iss 2-2 against the spread this college football season (-0.15 Units / -3.45% ROI).

LSU is 2-1 when betting on the Moneyline for +1.75 Units / 42.68% ROI
LSU is 0-4 when betting the Over for -4.4 Units / -100% ROI
LSU is 4-0 when betting the Under for +4 Units / 90.91% ROI

South Carolina: Keys to the Game vs. LSU

South Carolina’s opponents attempted two-point conversions on 24% of PATs last season– 2nd-highest among Power Conference Teams; Average: 8%

South Carolina has allowed 4 TDs in close and late situations this season– most in the SEC

South Carolina’s opponents attempted two-point conversions on 24% of PATs last season– 2nd-highest in FBS; Average: 8%

South Carolina opponents averaged 39.6 Passing Attempts per TD (396 Pass Attempts/10 Passing TDs) last season– 3rd-best among Power Conference Teams; Average: 21.7

South Carolina allowed a Completion Pct of just 31% (9 completions/29 attempts) in the Red Zone last season– 2nd-best in FBS; Average: 54%

LSU: Keys to the Game vs. South Carolina

South Carolina was undefeated (7-0) when making 5 or more explosive passes in a game last season– T-best among Power Conference Teams; Average: .631

South Carolina was 9-3 (.750) when allowing less than 5 yards per rush last season– T-36th-best in FBS; Average: .632

South Carolina was 8-2 (.800) when making 7 or more explosive plays last season– T-27th-best in FBS; Average: .628

South Carolina is 9-6 (.600) when the opposing team rushes more than 30 times since the 2024 season– T-32nd-best in FBS; Average: .451

Matchup Notes for South Carolina vs. LSU