- The Colts are -3.5 point favorites vs the Bills
- Total (Over/Under): 38 points
- Watch the game on
Broadcast Channel
The Indianapolis Colts visit Highmark Stadium to take on the Buffalo Bills on Aug. 12. Kickoff is scheduled for 1:00pm EDT in Orchard Park.
The Colts are betting favorites in this preseason matchup, with the spread sitting at -3.5 (-110).
The Colts vs. Bills Over/Under is 38 total points for the game.
Bet now on Bills vs Colts & all NFL games with BetMGM
Colts vs. Bills Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Colts | -3.5 -110 | 38 -110 | -185 |
| Bills | +3.5 -110 | 38 -110 | +150 |
Colts vs. Bills Prediction
Based on recent trends, the winning team model predicts the Colts will win this preseason game with 58.7% confidence.
Colts vs Bills Spread Prediction
Based on recent against-the-spread trends, the model predicts the Colts will cover the spread with 51.0% confidence.
Both predictions factor in up-to-date player injuries for both the Colts and Bills, plus offensive & defensive matchups, recent games and key player performances this season.
Bet now on Bills vs Colts and all NFL games with BetMGM
Best Colts Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Colts players this preseason game, looking at profitable historical betting trends:
- Michael Pittman has hit the Receiving Yards Under in 12 of his last 14 games (+9.65 Units / 54% ROI)
- Michael Pittman has hit the Longest Reception Under in 11 of his last 13 games (+7.90 Units / 44% ROI)
- Matt Ryan has hit the Rushing Yards Under in his last 7 games (+7.00 Units / 74% ROI)
- Jonathan Taylor has hit the Rushing Yards Under in 8 of his last 10 games (+5.55 Units / 44% ROI)
- Kylen Granson has hit the Longest Reception Over in his last 5 games (+5.00 Units / 82% ROI)
Best Bills Player Prop Best Bets Today
And here are some top NFL player prop bets for Bills players for this preseason matchup, looking at profitable historical betting trends:
- James Cook has hit the Receiving Yards Under in his last 7 games (+7.00 Units / 74% ROI)
- Josh Allen has hit the Passing Yards Under in 10 of his last 13 games (+6.20 Units / 36% ROI)
- Josh Allen has hit the Longest Rush Under in his last 5 games (+5.00 Units / 79% ROI)
- Josh Allen has hit the Rushing Yards Under in his last 5 games (+5.00 Units / 79% ROI)
- Gabriel Davis has hit the Longest Reception Over in 7 of his last 9 games at home (+4.85 Units / 49% ROI)
Colts Best Bets:
- The Indianapolis Colts have covered the 3Q Spread in 11 of their last 15 games (+6.95 Units / 38% ROI)
- The Indianapolis Colts have hit the 1Q Moneyline in 4 of their last 5 away games (+6.60 Units / 132% ROI)
- The Indianapolis Colts have hit the 2Q Game Total Over in their last 5 away games (+5.00 Units / 85% ROI)
- The Indianapolis Colts have covered the 1Q Spread in their last 5 away games (+5.00 Units / 82% ROI)
- The Indianapolis Colts have scored first in 4 of their last 5 away games (+4.45 Units / 89% ROI)
Bills Best Bets:
- The Buffalo Bills have hit the 1Q Game Total Over in 14 of their last 17 games (+10.80 Units / 54% ROI)
- The Buffalo Bills have hit the 1H Game Total Over in 11 of their last 16 games (+6.60 Units / 36% ROI)
- The Buffalo Bills have hit the 3Q Game Total Over in their last 6 games (+6.05 Units / 85% ROI)
- The Buffalo Bills have hit the 1H Moneyline in 8 of their last 10 games at home (+6.00 Units / 18% ROI)
- The Buffalo Bills have hit the 2Q Moneyline in 11 of their last 17 games (+5.80 Units / 16% ROI)
Colts Against the Spread (ATS) Record
Against the spread last NFL season, the Colts went 6-11 (-5.9 Units / -32.07% ROI).
- Colts are 4-12 when betting on the Moneyline for -8.85 Units / -39.07% ROI
- Colts are 7-10 when betting the Over for -4 Units / -21.39% ROI
- Colts are 10-7 when betting the Under for +2.3 Units / ROI
Bills Against the Spread (ATS) Record
Against the spread last NFL season, the Bills went 8-9 (-1.85 Units / -9.34% ROI).
- Bills are 14-4 when betting on the Moneyline for +1.3 Units / 1.82% ROI
- Bills are 7-11 when betting the Over for -5.1 Units / -25.76% ROI
- Bills are 11-7 when betting the Under for +3.3 Units / 16.67% ROI
Indianapolis Colts: Keys to the Game vs. the Buffalo Bills
The Colts were 1-9-1 (.091) when throwing at least 1 interception last season — worst in NFL. The Bills intercepted 17 passes last season — tied for fourth-most in NFL.
The Colts were 1-4-1 (.167) when allowing 5 or more explosive passes in the 2022 season — 3rd-worst in NFL; League Avg: .444.
The Colts were 2-6 (.250) at home in the 2022 season — 4th-worst in NFL; League Avg: .560.
The Colts were 4-12-1 (.235) in the 2022 season — tied for 3rd-worst in NFL; League Avg: .496.
Buffalo Bills: Keys to the Game vs. the Indianapolis Colts
The Bills were 11-2 (.846) when forcing 1 or more turnovers last season — fourth-best in NFL. The Colts turned the ball over 32 times last season — most in NFL.
The Bills were undefeated (4-0) vs top 10 run offenses in the 2022 season — best in NFL; League Avg: .429.
The Bills were undefeated (9-0) when converting 55% or more of its red zone chances into touchdowns in the 2022 season — tied for best in NFL; League Avg: .578.
The Bills were 6-3 (.667) on the road in the 2022 season — tied for 4th-best in NFL; League Avg: .432.
Additional Matchup Notes for Indianapolis Colts vs. Buffalo Bills
The Bills threw 9 touchdown passes in the last 4 weeks of the regular season — tied for second-most in NFL. The Colts allowed 9 passing TDs in the last 4 weeks of the regular season — tied for second-most in NFL.
The Bills scored on 50% of their drives in the fourth quarter in the last 4 weeks of the regular season — tied for fourth-best in NFL. The Colts defense allowed scores on 46.2% of opponent drives in the 4th quarter in the last 4 weeks of the regular season — tied for fourth-worst in NFL.
Bills WRs were targeted 23 times inside the 10 yardline last season — tied for fifth-most in NFL. The Colts allowed 10 receiving touchdowns inside the 10 yardline to WRs last season — second-most in NFL.
The Colts scored on 28.9% of their drives last season — fourth-worst in NFL. The Bills defense allowed scores on 31% of opponent drives last season — third-best in NFL.
The Colts threw for 675 passing yards in 4 games (just 168.8 YPG) in the last 4 weeks of the regular season — fourth-worst in NFL. The Bills allowed just 158.0 passing yards per game in the last 4 weeks of the regular season — fourth-best in NFL.
The Colts had a third down conversion rate of just 24.1% in the last 4 weeks of the regular season — second-worst in NFL. The Bills defense allowed a third down conversion rate of just 30.0% in the last 4 weeks of the regular season — third-best in NFL.
Indianapolis Colts Offense: Important Stats
The Colts committed 32 turnovers in the 2022 season — most in NFL.
The Colts ran 38% of their plays in their opponent’s territory in the 4th quarter in the 2022 season — worst in NFL; League Avg: 49%.
The Colts converted first downs on just 2 of 26 plays (8%) when their QB was scrambling in the 2022 season — 2nd-worst in NFL; League Avg: 21%.
The Colts averaged 12.1 drives per TD in the 1st half in the 2022 season — worst Drives Per TD rate in NFL; League Avg: 4.7.
Buffalo Bills Offense: Important Stats
The Bills have run 24% of their plays in the red zone in the 4th quarter since the 2021 season — best in NFL; League Avg: 16%.
The Bills committed 6 turnovers in the red zone in the 2022 season — most in NFL.
The Bills have an average drive start position from the 32.7 yard line in the 1st quarter since the 2021 season — best in NFL; League Avg: 25.7.
The Bills had a third down conversion rate of 50% in the 2022 season — 2nd-best in NFL; League Avg: 39%.
Indianapolis Colts Defense: Important Stats
The Colts defense has allowed a passer rating of just 59.4 on 3rd and short (67 Pass Attempts) since the 2021 season — best in NFL; League Avg: 100.2.
The Colts defense blitzed on just 7% of plays in the 2022 season — lowest in NFL; League Avg: 13%.
The Colts defense allowed first downs on 12% of rush attempts on 3rd and long in the 2022 season — tied for 3rd-best in NFL; League Avg: 25%.
The Colts defense has allowed scores on 23% of opponent drives in the 3rd quarter since the 2021 season — 3rd-best in NFL; League Avg: 30%.
Buffalo Bills Defense: Important Stats
The Bills defense allowed 3.6 points per Red Zone drive in the 2022 season — best in NFL; League Avg: 4.3.
The Bills defense has allowed scores on 17% of opponent drives in the 3rd quarter since the 2021 season — best in NFL; League Avg: 30%.
The Bills defense has allowed 34 TD passes since the 2021 season — fewest in NFL.
The Bills defense has allowed 17.4 Points per Game (592/34) since the 2021 season — worst in NFL; League Avg: 22.4.
Looking to place a bet on this game with a First Bet Offer up to $1,000? Bet now on Bills vs Colts and all NFL games with BetMGM
Bet on NFL Odds at BetMGM
At BetMGM, you can bet online with updated NFL betting odds. And with live sports betting, the best online sports betting and mobile sports betting (with the BetMGM Sportsbook app) experiences are at BetMGM.
