Dolphins vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 2

• The 49ers are -12.5 point favorites vs the Dolphins
• Total (Over/Under): 46 points
• Watch this game on FOX

The Miami Dolphins (0-1-0) visit Levi’s Stadium to take on the San Francisco 49ers (1-0-0) on Sep. 20. Kickoff is scheduled for 4:25 pm in Santa Clara, CA.

The 49ers are betting favorites in this matchup, with the spread sitting at -12.5 (-130).

The Dolphins vs. 49ers Over/Under is 46 total points for the game.

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Dolphins vs. 49ers Odds, Spread, Over/Under

Dolphins vs. 49ers Prediction

The winning team model predicts the 49ers will win this game with 75.7% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Dolphins vs 49ers Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 67.4% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Dolphins players this game, looking at profitable historical betting trends:

Best Dolphins Player Prop Bets Today

• Ollie Gordon II has hit the Rushing Yards Under in 10 of his last 12 games (+7.65 Units / 55% ROI)
• Devon Achane has hit the Rushing Yards Over in 11 of his last 15 games (+6.30 Units / 36% ROI)
• Devon Achane has hit the Carries Under in 6 of his last 7 away games (+4.95 Units / 63% ROI)
• Ollie Gordon II has hit the Carries Under in 7 of his last 9 games (+4.75 Units / 43% ROI)
• Greg Dulcich has hit the Longest Reception Over in 7 of his last 9 games (+4.70 Units / 47% ROI)

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

• Demarcus Robinson has hit the Receptions Over in 10 of his last 15 games (+5.90 Units / 33% ROI)
• Jake Tonges has hit the Receptions Over in his last 5 games (+5.55 Units / 98% ROI)
• Christian McCaffrey has hit the Longest Rush Under in 12 of his last 18 games (+5.40 Units / 26% ROI)
• Kyle Juszczyk has hit the Longest Reception Over in 9 of his last 12 games (+5.35 Units / 38% ROI)
• Brock Purdy has hit the Rushing Yards Over in his last 5 games at home (+5.00 Units / 85% ROI)

Anytime Touchdown Scorer Bet for 49ers vs Dolphins

Dolphins Best Bets:

• The Miami Dolphins have hit the 2Q Moneyline in 9 of their last 16 games (+8.60 Units / 46% ROI)
• The Miami Dolphins have hit the 1H Game Total Over in 7 of their last 9 away games (+4.65 Units / 43% ROI)
• The Miami Dolphins have covered the 1Q Spread in 11 of their last 17 games (+3.70 Units / 17% ROI)
• The Miami Dolphins have hit the 4Q Game Total Over in 10 of their last 16 games (+3.00 Units / 16% ROI)
• The Miami Dolphins have hit the Game Total Over in 5 of their last 9 away games (+2.80 Units / 28% ROI)

49ers Best Bets:

• The San Francisco 49ers have hit the Moneyline in 14 of their last 21 games (+11.20 Units / 31% ROI)
• The San Francisco 49ers have hit the 3Q Game Total Over in 13 of their last 18 games (+6.75 Units / 30% ROI)
• The San Francisco 49ers have covered the Spread in 13 of their last 21 games (+5.40 Units / 23% ROI)
• The San Francisco 49ers have hit the 1H Game Total Over in 13 of their last 21 games (+4.90 Units / 21% ROI)
• The San Francisco 49ers have hit the 1H Moneyline in 12 of their last 21 games (+4.00 Units / 12% ROI)

Dolphins Against the Spread (ATS) Record

Against the spread this NFL season, the Dolphins are 0-1 (-1.1 Units / -100% ROI).

• Dolphins are 0-1 when betting on the Moneyline for -1 Units / -100% ROI
• Dolphins are 0-1 when betting the Over for -1.1 Units / -100% ROI
• DolphinsDolphinsDolphins are 1-0 when betting the Under for +1 Units / 90.91% ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 1-0 (+1 Units / 90.91% ROI).

• 49ers are 1-0 when betting on the Moneyline for +1.7 Units / 170% ROI
• 49ers are 0-1 when betting the Over for -1.1 Units / -100% ROI
• 49ers are 1-0 when betting the Under for +1 Units / 90.91% ROI

Miami Dolphins: Keys to the Game vs. the San Francisco 49ers

Dolphins are 3-10 (.231) when allowing 10 or more rushes of 4+ yards (T-7th-worst in NFL) and .800 when allowing 1ess than 10 plays of 4+ yards rushing since the 2025 season (T-9th-best in NFL).

Dolphins are 5-1 (.833) when the opposing team converts less than 55% of its red zone chances into touchdowns (T-4th-best in NFL) and just .167 when the opposing team converts 55% or more of its red zone chances into touchdowns since the 2025 season (T-4th-worst in NFL).

The Dolphins were 5-1 (.833) when the opposing team converts less than 55% of its red zone chances into touchdowns (6th-best in NFL) and just .182 when the opposing team converts 55% or more of its red zone chances into touchdowns last season (T-6th-worst in NFL).

The Dolphins are undefeated (3-0) when possessing the ball longer than their opponent since the 2025 season — T-best in NFL; League Avg: .656.

San Francisco 49ers: Keys to the Game vs. the Miami Dolphins

The 49ers are undefeated (8-0) when forcing at least one fumble since the 2025 season — T-best in NFL; League Avg: .653.

The 49ers were 8-1 (.889) when forcing 1 or more turnovers last season — T-best in NFL. The Dolphins turned the ball over 25 times last season — 4th-most in NFL.

The 49ers are 8-1 (.889) when allowing less than 7 explosive plays since the 2025 season — best in NFL; League Avg: .587.

The 49ers are undefeated (4-0) after a loss since the 2025 season — T-best in NFL; League Avg: .413.

Additional Matchup Notes for Miami Dolphins vs. San Francisco 49ers

The 49ers have been successful on 53.5% of pass attempts since the 2025 season — 2nd-best in NFL. The Dolphins have allowed a success rate of 52.1% on pass attempts since the 2025 season — worst in NFL.

The 49ers have been successful on 53.2% of pass attempts with motion since the 2025 season — 3rd-best in NFL. The Dolphins have allowed a success rate of 51.3% on pass attempts against motion since the 2025 season — 4th-worst in NFL.

The 49ers have been successful on 54.4% of plays they have run on play action passes since the 2025 season — 5th-best in NFL. The Dolphins have allowed a success rate of 53.7% on play action passes since the 2025 season — 4th-worst in NFL.

The Dolphins were successful on just 27.8% of pass attempts with motion last week — 5th-worst in NFL. The 49ers allowed a success rate of just 22.2% on pass attempts against motion last week — T-3rd-best in NFL.

The Dolphins were successful on just 33.3% of pass attempts on their opponent’s side of the field last week — 5th-worst in NFL. The 49ers allowed a success rate of just 29.4% on pass attempts on their own side of the field last week — 4th-best in NFL.

The Dolphins are 5-1 (.833) when not throwing an interception since the 2025 season — T-9th-best in NFL. The 49ers have intercepted 7 passes since the 2025 season — 4th-fewest in NFL.

Miami Dolphins Offense: Important Stats

The Dolphins ran successful plays on 30% of plays in the 3rd quarter last season — worst in NFL; League Avg: 45%.

The Dolphins have run successful plays on 30% of plays in the 3rd quarter since the 2025 season — worst in NFL; League Avg: 44%.

The Dolphins have averaged -0.83 epa per play against tight coverage since the 2025 season — 2nd-worst in NFL; League Avg: -0.50.

The Dolphins ran successful plays on 20% of plays in the 2nd half in Week 1 — 2nd-worst in NFL; League Avg: 43%.

San Francisco 49ers Offense: Important Stats

The 49ers have run 62% of their plays in their opponent’s territory in the 2nd half since the 2025 season — best in NFL; League Avg: 49%.

The 49ers have run 57% of their plays in their opponent’s territory since the 2025 season — best in NFL; League Avg: 48%.

The 49ers ran 57% of their plays in their opponent’s territory last season — best in NFL; League Avg: 48%.

The 49ers have run successful plays on 65% of pass attempts in the 3rd quarter since the 2025 season — best in NFL; League Avg: 48%.

Miami Dolphins Defense: Important Stats

The Dolphins defense allowed successful plays on 8% of plays in the 4th quarter in Week 1 — best in NFL; League Avg: 45%.

The Dolphins defense has allowed successful plays on 55% of rush attempts in the 3rd quarter since the 2025 season — worst in NFL; League Avg: 44%.

The Dolphins defense allowed successful plays on 61% of pass attempts in the 3rd quarter last season — worst in NFL; League Avg: 48%.

The Dolphins defense did not sack opposing QBs on any of 30 pass attempts in Week 1 — T-worst in NFL; League Avg: 7%.

San Francisco 49ers Defense: Important Stats

The 49ers defense has averaged a sack every 31.6 pass attempts (632 Pass Attempts/20 Sacks) since the 2025 season — worst attempts per sack rate in NFL; League Avg: 14.6.

The 49ers defense has sacked opposing QBs on just 3% of pass attempts (20/632) since the 2025 season — worst in NFL; League Avg: 7%.

The 49ers defense allowed successful plays on 72% of plays with a stacked front last season — worst in NFL; League Avg: 46%.

The 49ers defense has allowed successful plays on 70% of plays with a stacked front since the 2025 season — worst in NFL; League Avg: 47%.

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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