- The 49ers are -10 point favorites vs the Giants
- Total (Over/Under): 45 points
- Watch Thursday Night Football on Amazon Prime Video
The New York Giants (1-1) visit Levi’s Stadium to take on the San Francisco 49ers (2-0) on Sep. 21. Kickoff is scheduled for 8:15pm EDT in Santa Clara.
The 49ers are betting favorites in this Week 3 matchup, with the spread sitting at -10 (-110).
The Giants vs. 49ers Over/Under is 45 total points for the game.
Bet now on 49ers vs Giants & all NFL games with BetMGM
Giants vs. 49ers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Giants | +10 -110 | 45 -110 | +400 |
| 49ers | -10 -110 | 45 -110 | -550 |
Giants vs. 49ers Prediction
Based on recent trends, the winning team model predicts the 49ers will win this Week 3 game with 79.0% confidence.
Giants vs 49ers Spread Prediction
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 55.0% confidence.
Both predictions factor in up-to-date player injuries for both the Giants and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.
Bet now on 49ers vs Giants and all NFL games with BetMGM
Best Giants Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Giants players this Week 3 game, looking at profitable historical betting trends:
- Daniel Bellinger has hit the Longest Reception Under in 9 of his last 10 games (+7.80 Units / 62% ROI)
- Daniel Jones has hit the Interceptions Under in 12 of his last 15 games (+6.40 Units / 25% ROI)
- Daniel Bellinger has hit the Receptions Under in his last 6 away games (+6.00 Units / 72% ROI)
- Isaiah Hodgins has hit the Receiving Yards Over in 7 of his last 8 games (+6.00 Units / 67% ROI)
- Darius Slayton has hit the Longest Reception Over in 8 of his last 10 games (+5.60 Units / 47% ROI)
Best 49ers Player Prop Best Bets Today
And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:
- George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
- Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
- Christian McCaffrey has hit the Longest Rush Over in 12 of his last 17 games (+6.10 Units / 32% ROI)
- Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)
First Touchdown Scorer Bet for 49ers vs Giants
| Player Name | 1st TD Odds |
|---|---|
| Christian McCaffrey | +300 |
| Deebo Samuel | +700 |
| Brandon Aiyuk | +800 |
| Tyrion Davis-Price | |
| George Kittle | +1100 |
Anytime Touchdown Scorer Bet for 49ers vs Giants
| Player Name | Anytime TD Odds |
|---|---|
| Christian McCaffrey | -300 |
| Brayden Willis | |
| Deebo Samuel | +105 |
| Brandon Aiyuk | +105 |
| George Kittle | +180 |
Receiving Props: Total Receiving Yards for 49ers vs Giants
| Player Name | Over | Under |
|---|---|---|
| Deebo Samuel | 54.5 -115 | 54.5 -115 |
| Hodgins | 31.5 -120 | 31.5 -115 |
| Darius Slayton | 32.5 -110 | 32.5 -120 |
| Parris Campbell | 28.5 -115 | 28.5 -115 |
| Darren Waller | 45.5 -115 | 45.5 -115 |
Rushing Props: Total Rushing Yards for 49ers vs Giants
| Player Name | Over | Under |
|---|---|---|
| Daniel Jones | 35.5 -115 | 35.5 -115 |
| Christian Mccaffrey | 79.5 -115 | 79.5 -115 |
| Deebo Samuel | 15.5 -110 | 15.5 -120 |
Giants Best Bets:
- The New York Giants have hit the Team Total Over in 15 of their last 22 games (+6.90 Units / 27% ROI)
- The New York Giants have scored last in 12 of their last 19 games (+5.75 Units / 27% ROI)
- The New York Giants have covered the 2H Spread in 12 of their last 19 games (+4.30 Units / 21% ROI)
- The New York Giants have hit the 2H Game Total Over in 12 of their last 19 games (+4.20 Units / 20% ROI)
- The New York Giants have hit the 2H Moneyline in 5 of their last 10 away games (+4.05 Units / 37% ROI)
49ers Best Bets:
- The San Francisco 49ers have hit the 2H Moneyline in 8 of their last 10 games at home (+7.55 Units / 39% ROI)
- The San Francisco 49ers have hit the 4Q Moneyline in 12 of their last 20 games (+7.20 Units / 22% ROI)
- The San Francisco 49ers have covered the 2H Spread in 13 of their last 20 games (+6.55 Units / 30% ROI)
- The San Francisco 49ers have hit the 2Q Game Total Over in 13 of their last 20 games (+5.10 Units / 22% ROI)
- The San Francisco 49ers have hit the 3Q Moneyline in 6 of their last 8 games at home (+4.50 Units / 29% ROI)
Giants Against the Spread (ATS) Record
Against the spread this NFL season, the Giants went 0-2 (-2.1 Units / -100% ROI).
- Giants are 1-1 when betting on the Moneyline for +0 Units / 0% ROI
- Giants are 1-1 when betting the Over for -0.1 Units / -4.55% ROI
- Giants are 1-1 when betting the Under for -0.1 Units / ROI
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers went 1-0 (+1 Units / 45.45% ROI).
- 49ers are 2-0 when betting on the Moneyline for +2 Units / 43.48% ROI
- 49ers are 1-1 when betting the Over for -0.1 Units / -4.55% ROI
- 49ers are 1-1 when betting the Under for -0.1 Units / -4.55% ROI
New York Giants: Keys to the Game vs. the San Francisco 49ers
The Giants were winless (0-6) vs top 10 offenses in the 2022 season — tied for worst in NFL; League Avg: .315.
The Giants are winless (0-12) vs top 10 offenses since the 2021 season — worst in NFL; League Avg: .355.
The Giants are winless (0-10-1) when rushing less than 25 times since the 2021 season — tied for worst in NFL; League Avg: .288.
The Giants are 1-7 (.125) when the opposing team commits less than 30 yards in penalties since the 2021 season — worst in NFL; League Avg: .467.
San Francisco 49ers: Keys to the Game vs. the New York Giants
The 49ers are 12-1 (.923) when rushing for 120 or more yards since the 2022 season — fourth-best in NFL. The Giants have allowed an average of 144.1 rushing yards per game since the 2022 season — fourth-worst in NFL.
The 49ers are 9-3 (.750) vs top 10 pass offenses since the 2021 season — 2nd-best in NFL; League Avg: .363.
The 49ers are undefeated (15-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .552.
The 49ers were winless (0-4) when committing 2 or more turnovers in the 2022 season — tied for worst in NFL; League Avg: .296.
Additional Matchup Notes for New York Giants vs. San Francisco 49ers
49ers RBs have rushed for 10 or more yards on 13.0% of 439 carries since the 2022 season — tied for third-best in NFL. The Giants have allowed 10+ yards on 15.1% of carries to RBs since the 2022 season — tied for worst in NFL.
The 49ers are averaging 5.0 yards per carry since the 2022 season — best in NFL. The Giants have allowed 5.3 yards per carry since the 2022 season — second-worst in NFL.
49ers RBs have averaged 114.7 rushing yards per game since the 2022 season — fourth-best in NFL. The Giants have allowed an average of 144.1 rushing yards per game since the 2022 season — fourth-worst in NFL.
Giants RBs have averaged 7.9 targets per game since Week 13 of the 2022 Season — tied for third-highest in NFL. The 49ers have allowed 6.1 receptions per game to RBs since Week 13 of the 2022 Season — tied for second-worst in NFL.
New York Giants Offense: Important Stats
The Giants have completed passes for 20+ yards on just 65 of their 1,178 total passing attempts (6%) since the 2021 season — worst in NFL; League Avg: 9%.
The Giants have not scored on any drive in the 1st half this season — worst in NFL; League Avg: 37%.
The Giants ran 5% of their plays in the red zone in the 1st quarter in the 2022 season — worst in NFL; League Avg: 12%.
The Giants have started 4 drives inside their own 20 yard line in the 1st quarter since the 2022 season — fewest in NFL.
San Francisco 49ers Offense: Important Stats
The 49ers have completed passes for 20+ yards on 125 of their 1,078 total passing attempts (12%) since the 2021 season — best in NFL; League Avg: 9%.
The 49ers went three and out on 14% of their drives in the 2022 season — best in NFL; League Avg: 21%.
The 49ers have scored on 70% of their drives in the 1st half this season — tied for best in NFL; League Avg: 37%.
The 49ers have averaged 8.3 yards per attempt (8,902 yards/1,078 attempts) since the 2021 season — best in NFL; League Avg: 7.0.
New York Giants Defense: Important Stats
The Giants defense has not recorded a sack (56 pass attempts) this season — worst attempts per sack rate in NFL; League Avg: 14.2.
The Giants defense has allowed 20+ yard rushes 4 times this season — most in NFL.
The Giants defense blitzed on 23% of plays in the 2022 season — highest in NFL; League Avg: 13%.
The Giants defense forced 19 fumbles in the 2022 season — 2nd-most in NFL.
San Francisco 49ers Defense: Important Stats
The 49ers defense allowed successful plays on 27% of rush attempts in the 1st quarter in the 2022 season — best in NFL; League Avg: 42%.
The 49ers defense allowed scores on 26% of opponent drives in the 2022 season — best in NFL; League Avg: 36%.
The 49ers defense has averaged 2.0 interceptions per game (4/2) this season — 2nd-best in NFL; League Avg: 0.7.
The 49ers defense allowed 16.4 Points per Game (279/17) in the 2022 season — worst in NFL; League Avg: 21.8.
Looking to place a bet on this game with a First Bet Offer up to $1,500? Bet now on 49ers vs Giants and all NFL games with BetMGM
Bet on NFL Odds at BetMGM
Take your football entertainment to the next level with NFL betting.
From future like AFC Championship odds and NFC Championship odds to weekly betting on spreads, moneylines and parlays, there are thousands of opportunities for all fans.
And with the best sportsbook promos, you can get bigger potential payouts, Bonus Bets and more.
Log in to your BetMGM account today — or sign up for a new account via the online sportsbook or BetMGM Sportsbook iOS app or BetMGM Google Play app — to start betting!
