The Largest Pro Football Underdog Lines of Week 10

Last week, the NFL had some of the biggest upsets of the season. Now, Week 10 starts the second half of the 2021 season, and bettors will be looking to see what underdog betting lines are out there this week.

BetMGM’s latest NFL betting lines have a few teams as double-digit underdogs.

What are the most significant pro football underdog lines this week? And do any of those underdogs have a chance to cover? First, let’s review these games.

Jets (+13) vs. Bills

BetMGM has the Jets as the biggest underdog in Week 10, getting 13 points against the Bills.

The Jets have admittedly not been the most reliable team to back this year, being just 2-6 overall and ATS. However, when they come through, they come through big. They were a big underdog at home this year in two games, and they won outright against the Titans and Bengals, respectively.

New York has magic in them at times, and the Bills do not look like the most reliable team to back, considering that they are coming off of a loss to the Jaguars.

Buffalo has been a little tricky to predict ATS this year, with a 4-3-1 record and a 1-2 record ATS as a road favorite. Meanwhile, the Jets are 2-1 as a home underdog ATS.

It is hard to believe that the Bills will come out flat again, but you need to remember that the Jets have come through in this spot before.

Jaguars (+10.5) at Colts

The Jaguars are coming off of their biggest win of the season against the Bills. The Jets were in a similar situation, traveling to Indianapolis after a big home win, and they ended up getting blown out.

Have the Jaguars proven they are a reliable team to back? Not really. They are just 3-5 ATS this season, while the Colts are 6-3. On top of that, the Colts are 4-0 overall and ATS when facing a team under .500.

Against a familiar foe like the Colts, I expect the Jaguars to come back down to earth in this game.

Panthers (+10) at Cardinals

The last double-digit underdog of the week is Carolina, who has gone from 3-0 to a measly 4-5 overall. Because of their recent slide, they have found themselves as 10-point underdogs going up against one of the hottest teams in football.

Arizona has the best overall record in the NFL at 8-1 and the third-best record ATS at 7-2. In comparison, Carolina is 4-5 ATS this year.

If that was not enough, last week proved that injuries to key players such as QB Kyler Murray and WR DeAndre Hopkins do not slow Arizona down, as they cruised to a road win against the 49ers.

This will be a matchup of elite defenses, with both being in the top five in the NFL in yards allowed. However, Arizona has an offense near the top of the league while Carolina is near the bottom.

With that in mind, Carolina may not be the most reliable underdog to back.

See More Pro Football Underdog Lines

These are the three most prominent pro football underdog lines in the NFL this week. Do you want to see more big underdogs?

Look for the latest sports betting lines at BetMGM. Create an account today and place your bets on this season’s NFL action.