• The Guardians are -140 favorites vs the Angels
• Angels vs Guardians Over / Under today: 8.5 Runs
• Angels / Guardians TV Channel: GDTV | ANTV

The Los Angeles Angels (+115) visit Progressive Field to take on the Cleveland Guardians (-140) on May 12, 2026. First pitch is scheduled for 6:10 pm in Cleveland, OH.

This season, the Angels are 16-26 against the spread (ATS), while the Guardians are 22-21 ATS.

Angels vs Guardians Starting Pitchers Today:

• Angels starting pitcher: Walbert Urena 1-3, 3.23 ERA
• Guardians starting pitcher: Slade Cecconi 2-4, 6.15 ERA

Angels vs. Guardians Odds, Run Line, Over/Under & Moneyline

Angels vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Tuesday‘s MLB game with 56.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Angels players for Tuesday‘s game, looking at profitable historical betting trends:

Best Angels Player Prop Bets Today:

• Jo Adell has hit the Singles Over in 18 of his last 25 away games (+14.35 Units / 56% ROI)
• Jo Adell has hit the RBIs Over in 10 of his last 15 away games (+11.35 Units / 76% ROI)
• Yoan Moncada has hit the Runs Under in his last 10 games (+10.00 Units / 54% ROI)
• Josh Lowe has hit the Hits Under in 16 of his last 25 games (+9.95 Units / 40% ROI)
• Yoan Moncada has hit the Walks Under in 13 of his last 15 games (+9.70 Units / 40% ROI)

And here are some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Daniel Schneemann has hit the Total Bases Over in 19 of his last 25 games (+12.00 Units / 35% ROI)
• Jose Ramirez has hit the RBIs Under in 17 of his last 20 games (+11.70 Units / 31% ROI)
• Daniel Schneemann has hit the Hits Over in 19 of his last 25 games (+10.20 Units / 28% ROI)
• Kyle Manzardo has hit the Hits Runs and RBIs Under in 18 of his last 25 games at home (+9.55 Units / 29% ROI)
• Rhys Hoskins has hit the Runs Over in 12 of his last 20 games (+9.50 Units / 47% ROI)

Angels Best Bets Today:

• The Los Angeles Angels have hit the Team Total Under in 28 of their last 45 away games (+10.00 Units / 19% ROI)
• The Los Angeles Angels have hit the Game Total Under in 9 of their last 12 games (+5.70 Units / 43% ROI)
• The Los Angeles Angels have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 35 games (+5.00 Units / 12% ROI)
• The Los Angeles Angels have hit the 1st Five Innings (F5) Moneyline in 17 of their last 35 games (+3.35 Units / 8% ROI)
• The Los Angeles Angels have covered the 1st Five Innings (F5) Run Line in 23 of their last 40 games (+3.15 Units / 7% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have covered the Run Line in 23 of their last 40 games at home (+10.20 Units / 21% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 10 of their last 12 games (+7.65 Units / 52% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 24 of their last 40 games (+7.25 Units / 16% ROI)
• The Cleveland Guardians have hit the Moneyline in 25 of their last 40 games at home (+6.90 Units / 13% ROI)
• The Cleveland Guardians have hit the Game Total Under in 21 of their last 35 games at home (+6.45 Units / 16% ROI)

Angels Against the Spread (ATS) Record

Against the spread this season, the Angels are 19-22 against the Run Line (-9.5 Units / -16.83% ROI).

• 16-26 when betting on the Moneyline for -6.55 Units / -14.64% ROI
• 20-21 when betting on the total runs Over for -2.85 Units / -6.13% ROI
• 21-20 when betting on the total runs Under for -0.5 Units / -1.09% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 22-21 against the Run Line (+1.1 Units / 2.04% ROI).

• 22-21 when betting on the Moneyline for +0.9 Units / 1.78% ROI
• 22-21 when betting on the total runs Over for -0.95 Units / -2.01% ROI
• 21-22 when betting on the total runs Under for -3.35 Units / -7.05% ROI

Guardians vs Angels Home Run Prop Bets Today

Guardians vs Angels Total Hits Prop Bets Today

Guardians vs Angels Strikeout Prop Bets Today

Angels Keys to the Game vs. the Guardians

The Angels are just 2-19 (.095) when allowing 5 or more runs this season — lowest in MLB; League Avg: .211.

The Angels are just 0-18 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .106.

The Angels are just 5-21 (.192) when scoring 4 or fewer runs this season — 3rd lowest in MLB; League Avg: .279.

The Angels are just 16-23 (.410) when allowing 5 or more extra base hits this season — tied for 2nd lowest in MLB; League Avg: .532.

Guardians Keys to the Game vs. the Angels

The Guardians are just 7-14 (.333) after a win this season — 2nd lowest in MLB; League Avg: .530.

The Guardians are just 0-19 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

The Guardians are 16-1 (.941) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .860.

The Guardians are 43-16 (.717) when they’ve scored in the first inning since the 2025 season — 5th best in MLB; League Avg: .634.

Angels Hitting Stats & Trends

The Angels are batting just .213 at home this season — 2nd lowest in MLB.

Angels hitters have put just 33% of their swings in play this season — lowest in MLB.

Angels hitters are slugging just .329 at home this season — 3rd lowest in MLB.

Angels hitters have struck out in 25% of their PA’s this season — 2nd highest in MLB.

Guardians Hitting Stats & Trends

Guardians hitters are averaging 4.08 pitches per plate appearance this season — highest in MLB.

Guardians hitters have put just 30% of their swings in play on the first pitch of at-bats this season — lowest in MLB.

8% of Guardians’ hitters plate appearances have lasted only one pitch (134/1,625 PA’s) this season — lowest in MLB.

Guardians hitters are slugging just .351 against RHP this season — 3rd lowest in MLB.

Angels Pitching Stats & Trends

Angels pitchers have walked 12% of batters this season — 2nd highest in MLB.

Angels pitchers have an ERA of 4.68 (369.1 IP) this season — 4th highest in MLB.

Opponents have a miss rate of 28% against Angels pitchers this season — tied for best in MLB.

Opponents have a groundball rate of 46% against Angels pitchers this season — 5th highest in MLB.

Guardians Pitching Stats & Trends

Opponents have a miss rate of 28% against Guardians pitchers this season — tied for 3rd best in MLB.

Guardians pitchers have struck out 28% of left-handed batters they faced this season — best in MLB.

Guardians pitchers have a strikeout rate of 34% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — 3rd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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