• The Cubs are -155 favorites vs the Astros
• Astros vs Cubs Over / Under today: 7.5 Runs
• Astros / Cubs TV Channel: MARQ | SCHN | ESUN

The Houston Astros (+125) visit Wrigley Field to take on the Chicago Cubs (-155) on May 23, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Astros are 21-31 against the spread (ATS), while the Cubs are 21-30 ATS.

Astros vs Cubs Starting Pitchers Today:

• Astros starting pitcher: Kai-Wei Teng 2-3, 2.64 ERA
• Cubs starting pitcher: Colin Rea 4-2, 4.98 ERA

Astros vs. Cubs Odds, Run Line, Over/Under & Moneyline

Astros vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Saturday‘s MLB game with 57.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Saturday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Christian Vazquez has hit the Home Runs Over in 2 of his last 6 away games (+17.00 Units / 283% ROI)
• Yordan Alvarez has hit the RBIs Under in 21 of his last 25 games (+14.35 Units / 32% ROI)
• Yordan Alvarez has hit the Runs Under in 19 of his last 25 games (+12.70 Units / 44% ROI)
• Yordan Alvarez has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+12.50 Units / 43% ROI)
• Isaac Paredes has hit the Hits Over in 17 of his last 20 away games (+11.95 Units / 34% ROI)

And here are some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Michael Busch has hit the Walks Over in 17 of his last 25 games (+13.05 Units / 51% ROI)
• Nico Hoerner has hit the Hits Under in 20 of his last 25 games (+12.15 Units / 23% ROI)
• Pete Crow-Armstrong has hit the Home Runs Over in 2 of his last 6 games at home (+12.10 Units / 202% ROI)
• Ian Happ has hit the Total Bases Under in 18 of his last 25 games (+11.55 Units / 35% ROI)
• Michael Busch has hit the Runs Under in 19 of his last 25 games (+10.45 Units / 26% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Team Total Under in 18 of their last 23 games (+11.25 Units / 39% ROI)
• The Houston Astros have hit the Game Total Under in 9 of their last 13 games (+6.90 Units / 50% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 30 away games (+5.55 Units / 16% ROI)
• The Houston Astros have hit the Moneyline in 6 of their last 11 away games (+2.20 Units / 20% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 4 of their last 7 games (+1.65 Units / 23% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Moneyline in 15 of their last 19 games at home (+9.85 Units / 35% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 games at home (+7.80 Units / 13% ROI)
• The Chicago Cubs have hit the Team Total Under in 10 of their last 12 games (+7.70 Units / 51% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 12 games (+7.60 Units / 50% ROI)
• The Chicago Cubs have covered the Run Line in 19 of their last 35 games at home (+4.95 Units / 12% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 21-31 against the Run Line (-15.2 Units / -22.25% ROI).

• 21-31 when betting on the Moneyline for -11.75 Units / -19.36% ROI
• 28-21 when betting on the total runs Over for +4.1 Units / 7.01% ROI
• 21-28 when betting on the total runs Under for -9.4 Units / -16.8% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 21-30 against the Run Line (-9.85 Units / -16.46% ROI).

• 29-22 when betting on the Moneyline for +1.8 Units / 2.59% ROI
• 28-22 when betting on the total runs Over for +4.4 Units / 7.89% ROI
• 22-28 when betting on the total runs Under for -8.75 Units / -15.46% ROI

Cubs vs Astros Home Run Prop Bets Today

Cubs vs Astros Total Hits Prop Bets Today

Cubs vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Cubs

The Astros are just 1-17 (.056) when allowing 10 or more hits this season — lowest in MLB; League Avg: .248.

The Astros are just 7-13 (.350) after a win this season — 2nd lowest in MLB; League Avg: .525.

The Astros are just 0-27 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .141.

The Astros are just 9-17 (.346) on the road this season — tied for 5th lowest in MLB; League Avg: .473.

Cubs Keys to the Game vs. the Astros

The Cubs are 23-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .893.

The Cubs are 8-1 (.889) when they’ve scored in the first inning this season — best in MLB; League Avg: .631.

The Cubs are 22-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .859.

The Cubs are 14-1 (.933) when they’ve had 10 or more hits this season — tied for 2nd best in MLB; League Avg: .752.

Astros Hitting Stats & Trends

The Astros are batting .309 when facing the starting pitcher for the 3rd time in a game this season — 2nd best in MLB.

The Astros are batting .267 on the road this season — 2nd best in MLB.

Astros hitters have an OBP of .336 (1,014 PA’s) on the road this season — 2nd best in MLB.

Astros hitters have struck out in just 19% of their PA’s against LHP this season — 5th best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .353 (617 PA’s) against LHP this season — 2nd best in MLB.

Cubs hitters have struck out in just 21% of their PA’s against RHP this season — tied for 5th best in MLB.

Cubs hitters have an OBP of .380 (454 PA’s) when leading off an inning this season — best in MLB.

Cubs hitters have drawn walks in 12% of their PA’s against RHP this season — 2nd best in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 12% of batters this season — highest in MLB.

Astros pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — lowest in MLB.

Astros pitchers have allowed an OBP of .358 (2,029 PA’s) this season — highest in MLB.

Cubs Pitching Stats & Trends

The Cubs pitchers have allowed an average Exit Velocity of 90.2 MPH this season (1,266 balls in play) — tied for highest in MLB

Opponents have a groundball batting average of just .208 against Cubs pitchers with runners on base this season — 2nd best in MLB.

Cubs pitchers have allowed an average Exit Velocity of 90.2 MPH (1,266 batted balls) this season — tied for highest in MLB.

Cubs pitchers have allowed 68 home runs this season — tied for 2nd most in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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