• The Astros are -105 favorites vs the Guardians
• Astros vs Guardians Over / Under today: 8 Runs
• Astros / Guardians TV Channel: GDTV | SCHN

The Houston Astros (-105) visit Progressive Field to take on the Cleveland Guardians (-115) on April 20, 2026. First pitch is scheduled for 6:10 pm in Cleveland, OH.

This season, the Astros are 8-15 against the spread (ATS), while the Guardians are 13-10 ATS.

Astros vs Guardians Starting Pitchers Today:

• Astros starting pitcher: Spencer Arrighetti 1-0, 1.50 ERA
• Guardians starting pitcher: Slade Cecconi 0-2, 5.04 ERA

Astros vs. Guardians Odds, Run Line, Over/Under & Moneyline

Astros vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Monday‘s MLB game with 53.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Monday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Yordan Alvarez has hit the Home Runs Over in 6 of his last 10 games (+14.90 Units / 149% ROI)
• Carlos Correa has hit the Runs Over in 16 of his last 25 away games (+11.70 Units / 46% ROI)
• Christian Walker has hit the Hits Over in 19 of his last 25 away games (+10.95 Units / 25% ROI)
• Christian Walker has hit the Total Bases Over in 17 of his last 25 away games (+9.95 Units / 35% ROI)
• Yordan Alvarez has hit the RBIs Over in 8 of his last 10 games (+9.05 Units / 90% ROI)

And here are some favorite MLB player prop bets for Guardians players for Monday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Brayan Rocchio has hit the Home Runs Over in 2 of his last 6 games (+19.00 Units / 317% ROI)
• Steven Kwan has hit the Hits Under in 15 of his last 25 games at home (+10.25 Units / 28% ROI)
• Kyle Manzardo has hit the Hits Runs and RBIs Under in 12 of his last 15 games at home (+8.80 Units / 45% ROI)
• Daniel Schneemann has hit the Runs Over in his last 5 games (+8.55 Units / 171% ROI)
• Chase DeLauter has hit the Walks Over in 7 of his last 10 games (+8.25 Units / 82% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 16 of their last 21 games (+10.20 Units / 43% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 25 of their last 40 away games (+7.75 Units / 16% ROI)
• The Houston Astros have hit the Team Total Over in 13 of their last 21 games (+3.55 Units / 14% ROI)
• The Houston Astros have covered the Run Line in 27 of their last 50 away games (+3.25 Units / 5% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 33 of their last 50 games (+19.25 Units / 33% ROI)
• The Cleveland Guardians have covered the Run Line in 31 of their last 50 games (+14.60 Units / 23% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 23 of their last 50 games (+10.40 Units / 18% ROI)
• The Cleveland Guardians have hit the Game Total Under in 30 of their last 50 games (+10.10 Units / 18% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 games (+9.65 Units / 17% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 8-15 against the Run Line (-6.85 Units / -25.95% ROI).

• 8-15 when betting on the Moneyline for -11.8 Units / -37.7% ROI
• 16-7 when betting on the total runs Over for +7.9 Units / 30.38% ROI
• 7-16 when betting on the total runs Under for -10.3 Units / -41.87% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 13-10 against the Run Line (+3.2 Units / 10.98% ROI).

• 13-10 when betting on the Moneyline for +5.4 Units / 21.22% ROI
• 11-12 when betting on the total runs Over for -2 Units / -7.92% ROI
• 12-11 when betting on the total runs Under for -0.15 Units / -0.59% ROI

Guardians vs Astros Home Run Prop Bets Today

Guardians vs Astros Total Hits Prop Bets Today

Guardians vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Guardians

The Astros are just 8-14 (.364) when allowing 5 or more extra base hits this season — 2nd lowest in MLB; League Avg: .524.

The Astros are just 1-9 (.100) on the road this season — lowest in MLB; League Avg: .448.

The Astros are just 1-9 (.100) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .285.

The Astros were 56-7 (.889) when they scored 5 or more runs in the 2025 season — 3rd best in MLB; League Avg: .797.

Guardians Keys to the Game vs. the Astros

The Guardians are just 3-9 (.250) after a win this season — lowest in MLB; League Avg: .540.

The Guardians are 36-4 (.878) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .749.

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

The Guardians are just 0-9 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

Astros Hitting Stats & Trends

Astros hitters have struck out in just 9% of their PA’s against LHP over the past seven days (3 games) — best in MLB.

Astros hitters have an OPS of 1.254 (50 PA’s) in lefty-lefty matchups this season — best in MLB.

Astros hitters have an OPS of .933 (159 PA’s) in lefty-lefty matchups since the 2025 season — best in MLB.

Astros hitters are slugging .814 in lefty-lefty matchups this season — best in MLB.

Guardians Hitting Stats & Trends

The Guardians batted just .223 against LHP in the 2025 season — 3rd lowest in MLB.

Guardians hitters are averaging 4.19 pitches per plate appearance this season — highest in MLB.

Guardians hitters have struck out in 35% of their PA’s in righty-righty matchups this season — highest in MLB.

The Guardians are batting just .191 in righty-righty matchups since the 2025 season — lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have an ERA of 7.98 (82.1 IP) on the road this season — highest in MLB.

The Astros have allowed 7.50 runs per game (75/10) on the road this season — highest in MLB.

Opponents have a miss rate of 28% against Astros pitchers since the 2025 season — best in MLB.

Astros pitchers had a strikeout rate of 25% in the 2025 season — best in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 39% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 27% this season — best in MLB.

Guardians pitchers had an ERA of 3.72 (706.0 IP) on the road in the 2025 season — tied for best in MLB.

Opponents had a chase percentage of just 26% against the Guardians pitchers in the 2025 season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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