• The Guardians are -145 favorites vs the Astros
• Astros vs Guardians Over / Under today: 8 Runs
• Astros / Guardians TV Channel: GDTV | SCHN

The Houston Astros (+120) visit Progressive Field to take on the Cleveland Guardians (-145) on April 22, 2026. First pitch is scheduled for 1:10 pm in Cleveland, OH.

This season, the Astros are 9-16 against the spread (ATS), while the Guardians are 14-11 ATS.

Astros vs Guardians Starting Pitchers Today:

• Astros starting pitcher: Peter Lambert 0-1, 7.21 ERA
• Guardians starting pitcher: Tanner Bibee 0-2, 4.81 ERA

Astros vs. Guardians Odds, Run Line, Over/Under & Moneyline

Astros vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s MLB game with 57.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Wednesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Brice Matthews has hit the Home Runs Over in 3 of his last 8 away games (+18.90 Units / 236% ROI)
• Carlos Correa has hit the Hits Over in 18 of his last 25 away games (+12.05 Units / 28% ROI)
• Carlos Correa has hit the Total Bases Over in 17 of his last 25 away games (+11.60 Units / 40% ROI)
• Jose Altuve has hit the Runs Under in 16 of his last 20 away games (+11.20 Units / 39% ROI)
• Yordan Alvarez has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+8.30 Units / 28% ROI)

And here are some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Brayan Rocchio has hit the Home Runs Over in 2 of his last 8 games (+17.00 Units / 212% ROI)
• Kyle Manzardo has hit the Hits Runs and RBIs Under in 16 of his last 20 games at home (+11.55 Units / 45% ROI)
• Steven Kwan has hit the Hits Under in 15 of his last 25 games at home (+10.80 Units / 30% ROI)
• Chase DeLauter has hit the Singles Under in 16 of his last 20 games (+10.55 Units / 38% ROI)
• Kyle Manzardo has hit the Runs Under in his last 10 games at home (+10.00 Units / 52% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 18 of their last 23 games (+12.20 Units / 47% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 26 of their last 40 away games (+10.20 Units / 21% ROI)
• The Houston Astros have hit the Team Total Over in 15 of their last 23 games (+5.55 Units / 20% ROI)
• The Houston Astros have covered the 1st Five Innings (F5) Run Line in 22 of their last 40 away games (+1.75 Units / 4% ROI)
• The Houston Astros have covered the Run Line in 26 of their last 50 away games (+0.75 Units / 1% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 33 of their last 50 games (+18.60 Units / 31% ROI)
• The Cleveland Guardians have covered the Run Line in 31 of their last 50 games (+15.35 Units / 24% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 28 of their last 45 games (+8.80 Units / 16% ROI)
• The Cleveland Guardians have hit the Game Total Under in 29 of their last 50 games (+8.10 Units / 15% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 29 of their last 50 games (+7.45 Units / 13% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 9-16 against the Run Line (-7.35 Units / -24.66% ROI).

• 9-16 when betting on the Moneyline for -11.65 Units / -34.99% ROI
• 18-7 when betting on the total runs Over for +9.9 Units / 35.04% ROI
• 7-18 when betting on the total runs Under for -12.5 Units / -46.64% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 14-11 against the Run Line (+3.5 Units / 11.24% ROI).

• 14-11 when betting on the Moneyline for +5.05 Units / 17.84% ROI
• 13-12 when betting on the total runs Over for +0 Units / 0% ROI
• 12-13 when betting on the total runs Under for -2.35 Units / -8.48% ROI

Guardians vs Astros Home Run Prop Bets Today

Guardians vs Astros Total Hits Prop Bets Today

Guardians vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Guardians

The Astros are just 0-14 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .105.

The Astros are just 2-10 (.167) on the road this season — tied for 2nd lowest in MLB; League Avg: .462.

The Astros are just 1-9 (.100) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .278.

The Astros were 71-4 (.947) when leading entering the 8th inning in the 2025 season — tied for 2nd best in MLB; League Avg: .909.

Guardians Keys to the Game vs. the Astros

The Guardians are just 3-10 (.231) after a win this season — lowest in MLB; League Avg: .536.

The Guardians are 37-4 (.881) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .749.

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

The Guardians are just 0-10 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .050.

Astros Hitting Stats & Trends

Astros hitters have an OPS of 1.144 (59 PA’s) in lefty-lefty matchups this season — best in MLB.

Astros hitters have an OPS of .910 (168 PA’s) in lefty-lefty matchups since the 2025 season — best in MLB.

Astros hitters are slugging .438 this season — 3rd best in MLB.

The Astros are batting .333 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Guardians Hitting Stats & Trends

The Guardians batted just .226 in the 2025 season — 2nd lowest in MLB.

Guardians hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

Guardians hitters have put just 27% of their swings in play on the first pitch of at-bats this season — lowest in MLB.

Guardians hitters had an OPS of just .618 (1,849 PA’s) in innings 7-9 in the 2025 season — 2nd lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have an ERA of 6.05 (217.1 IP) this season — highest in MLB.

Astros pitchers have walked 14% of batters this season — highest in MLB.

Astros pitchers have an ERA of 7.52 (99.1 IP) on the road this season — highest in MLB.

The Astros have allowed 4.04 runs per game (101/25) in the first 5 innings this season — highest in MLB.

Guardians Pitching Stats & Trends

Opponents had a chase percentage of just 26% against the Guardians pitchers in the 2025 season — lowest in MLB.

Guardians pitchers have a strikeout rate of 37% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 26% this season — 3rd best in MLB.

Guardians pitchers have an ERA of 2.51 (498.1 IP) against division opponents since the 2025 season — best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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