• The Mariners are -150 favorites vs the Astros
• Astros vs Mariners Over / Under today: 7.5 Runs
• Astros / Mariners TV Channel: MRTV | SCHN

The Houston Astros (+125) visit T-Mobile Park to take on the Seattle Mariners (-150) on September 22, 2026. First pitch is scheduled for 9:40 pm in Seattle, WA.

This season, the Astros are 77-79 against the spread (ATS), while the Mariners are 58-97 ATS.

Astros vs Mariners Starting Pitchers Today:

• Astros starting pitcher: Cristian Javier 2-6, 5.32 ERA
• Mariners starting pitcher: Logan Gilbert 12-10, 3.72 ERA

Astros vs. Mariners Odds, Run Line, Over/Under & Moneyline

Astros vs Mariners Prediction for Today’s Game

Based on recent trends the model predicts the Mariners will win Tuesday‘s MLB game with 54.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Mariners and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Tuesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Cam Smith has hit the Home Runs Over in 3 of his last 6 away games (+16.40 Units / 273% ROI)
• Christian Walker has hit the Runs Under in 18 of his last 20 games (+13.55 Units / 35% ROI)
• Cam Smith has hit the Hits Under in 17 of his last 25 games (+12.85 Units / 51% ROI)
• Yainer Diaz has hit the Total Bases Over in 14 of his last 20 games (+12.80 Units / 56% ROI)
• Cam Smith has hit the Singles Under in 20 of his last 25 games (+11.45 Units / 28% ROI)

And here are some favorite MLB player prop bets for Mariners players for Tuesday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Best Bets Today:

• J.P. Crawford has hit the Home Runs Over in 3 of his last 8 games (+17.90 Units / 224% ROI)
• Dominic Canzone has hit the Hits Over in 20 of his last 25 games (+13.75 Units / 32% ROI)
• J.P. Crawford has hit the Hits Runs and RBIs Under in 20 of his last 25 games at home (+12.85 Units / 38% ROI)
• Dominic Canzone has hit the Singles Over in 9 of his last 10 games at home (+9.05 Units / 88% ROI)
• Logan Gilbert has hit the Earned Runs Over in 12 of his last 15 games (+8.95 Units / 44% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 35 away games (+13.65 Units / 32% ROI)
• The Houston Astros have hit the Moneyline in 30 of their last 50 away games (+11.80 Units / 22% ROI)
• The Houston Astros have hit the Team Total Under in 26 of their last 40 games (+9.95 Units / 21% ROI)
• The Houston Astros have hit the Game Total Under in 15 of their last 23 games (+9.90 Units / 40% ROI)
• The Houston Astros have covered the Run Line in 31 of their last 50 away games (+7.80 Units / 11% ROI)

Mariners Best Bets Today:

• The Seattle Mariners have hit the Game Total Over in 22 of their last 35 games (+8.75 Units / 23% ROI)
• The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Over in 22 of their last 35 games (+8.05 Units / 19% ROI)
• The Seattle Mariners have hit the Team Total Under in 26 of their last 45 games at home (+5.40 Units / 10% ROI)
• The Seattle Mariners have hit the 1st Five Innings (F5) Moneyline in 6 of their last 8 games (+3.20 Units / 26% ROI)
• The Seattle Mariners have covered the 1st Five Innings (F5) Run Line in 5 of their last 8 games (+1.65 Units / 18% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 79-77 against the Run Line (-3.7 Units / -1.78% ROI).

• 77-79 when betting on the Moneyline for -12.65 Units / -6.74% ROI
• 75-71 when betting on the total runs Over for -4 Units / -2.31% ROI
• 71-75 when betting on the total runs Under for -11.1 Units / -6.52% ROI

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are 58-97 against the Run Line (-37.05 Units / -20.39% ROI).

• 73-83 when betting on the Moneyline for -32.7 Units / -15.61% ROI
• 81-67 when betting on the total runs Over for +7.4 Units / 4.29% ROI
• 67-81 when betting on the total runs Under for -21.65 Units / -12.65% ROI

Astros Keys to the Game vs. the Mariners

The Astros are 66-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Astros are 13-6 (.684) when tied entering the 8th inning this season — best in MLB.

The Astros are just 25-33 (.431) vs the bottom 10 runs allowed teams this season Today, they face the Mariners (14th fewest runs allowed).

The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.

Mariners Keys to the Game vs. the Astros

The Mariners are just 26-39 (.400) vs bottom 10 scoring offenses this season Today, they face the Astros (19th in runs scored).

The Mariners are just 23-26 (.469) when they’ve scored in the first inning this season — 2nd lowest in MLB.

The Mariners are just 12-60 (.167) when allowing 5 or more runs this season — 5th lowest in MLB.

The Mariners are just 2-70 (.028) when trailing entering the 8th inning this season — 2nd lowest in MLB.

Astros Hitting Stats & Trends

Astros hitters have 46 extra-base hits out of 176 total hits (just 26%) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Astros hitters have drawn walks in 13% of their PA’s with runners in scoring position this season — best in MLB.

Astros hitters have chased 32% of pitches out of the zone against LHP this season — 5th highest in MLB.

Astros hitters have an OBP of just .235 (3,084 PA’s) with two-strikes this season — 4th lowest in MLB.

Mariners Hitting Stats & Trends

The Mariners are just 58-98 (.372) against the run line (-21.3% ROI) this season — lowest in MLB.

Mariners hitters are slugging just .367 at home this season — 3rd lowest in MLB.

Mariners hitters are slugging just .349 against LHP this season — lowest in MLB.

Mariners hitters have an OPS of just .653 (1,961 PA’s) against LHP this season — 2nd lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

Astros pitchers have walked 10% of batters this season — 2nd highest in MLB.

The Astros have allowed 3.01 runs per game (470/156) in the first 5 innings this season — 3rd highest in MLB.

Mariners Pitching Stats & Trends

Mariners pitchers have walked 7% of batters this season — 2nd best in MLB.

Mariners pitchers have a first-pitch strike rate of 66% this season — highest in MLB.

Mariners pitchers have thrown at least two strikes in their first three pitches to 69% of opposing batters this season — highest in MLB.

Opponents have a swing rate of 51% against the Mariners pitchers this season — highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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