• The Astros are +100 favorites vs the Orioles
• Astros vs Orioles Over / Under today: 9 Runs
• Astros / Orioles TV Channel: MASN | SCHN

The Houston Astros (+100) visit Oriole Park at Camden Yards to take on the Baltimore Orioles (-120) on April 29, 2026. First pitch is scheduled for 6:35 pm in Baltimore, MD.

This season, the Astros are 11-19 against the spread (ATS), while the Orioles are 13-16 ATS.

Astros vs Orioles Starting Pitchers Today:

• Astros starting pitcher: Peter Lambert 1-1, 3.38 ERA
• Orioles starting pitcher: Chris Bassitt 1-2, 6.65 ERA

Astros vs. Orioles Odds, Run Line, Over/Under & Moneyline

Astros vs Orioles Prediction for Today’s Game

Based on recent trends the model predicts the Orioles will win Wednesday‘s MLB game with 52.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Orioles and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Wednesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Brice Matthews has hit the Home Runs Over in 4 of his last 10 away games (+23.70 Units / 237% ROI)
• Jose Altuve has hit the Runs Under in 17 of his last 20 away games (+13.75 Units / 47% ROI)
• Jose Altuve has hit the Total Bases Under in 19 of his last 25 away games (+10.80 Units / 28% ROI)
• Carlos Correa has hit the Hits Over in 18 of his last 25 away games (+10.60 Units / 23% ROI)
• Jose Altuve has hit the Hits Runs and RBIs Under in 18 of his last 25 away games (+9.80 Units / 32% ROI)

And here are some favorite MLB player prop bets for Orioles players for Wednesday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Best Bets Today:

• Samuel Basallo has hit the Home Runs Over in 5 of his last 9 games at home (+24.70 Units / 274% ROI)
• Pete Alonso has hit the Walks Over in 12 of his last 20 games at home (+11.55 Units / 58% ROI)
• Jeremiah Jackson has hit the Singles Over in 12 of his last 15 games at home (+9.95 Units / 63% ROI)
• Taylor Ward has hit the Total Bases Over in 16 of his last 25 games (+8.85 Units / 29% ROI)
• Gunnar Henderson has hit the Hits Under in 13 of his last 20 games at home (+8.25 Units / 25% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 21 of their last 30 games (+10.70 Units / 32% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 23 of their last 35 games (+10.70 Units / 27% ROI)
• The Houston Astros have hit the Team Total Over in 26 of their last 45 games (+3.70 Units / 7% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 3 of their last 5 away games (+1.55 Units / 31% ROI)
• The Houston Astros have covered the Run Line in 26 of their last 50 away games (+0.85 Units / 1% ROI)

Orioles Best Bets Today:

• The Baltimore Orioles have hit the Game Total Under in 25 of their last 40 games at home (+9.70 Units / 22% ROI)
• The Baltimore Orioles have hit the Team Total Under in 28 of their last 45 games at home (+8.50 Units / 16% ROI)
• The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 games (+7.95 Units / 13% ROI)
• The Baltimore Orioles have covered the Run Line in 5 of their last 7 games (+4.55 Units / 52% ROI)
• The Baltimore Orioles have covered the 1st Five Innings (F5) Run Line in 7 of their last 12 games at home (+2.00 Units / 16% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 11-19 against the Run Line (-9.45 Units / -25.68% ROI).

• 11-19 when betting on the Moneyline for -12.1 Units / -31.59% ROI
• 21-9 when betting on the total runs Over for +10.7 Units / 31.8% ROI
• 9-21 when betting on the total runs Under for -13.9 Units / -42.9% ROI

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 13-16 against the Run Line (-3.45 Units / -9.43% ROI).

• 14-15 when betting on the Moneyline for -3.8 Units / -10.61% ROI
• 18-11 when betting on the total runs Over for +5.85 Units / 18.28% ROI
• 11-18 when betting on the total runs Under for -8.75 Units / -27.47% ROI

Orioles vs Astros Home Run Prop Bets Today

Orioles vs Astros Total Hits Prop Bets Today

Orioles vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Orioles

The Astros are just 6-12 (.333) after a loss this season — 3rd lowest in MLB; League Avg: .478.

The Astros are just 1-12 (.077) when allowing 10 or more hits this season — 2nd lowest in MLB; League Avg: .234.

The Astros are just 11-19 (.367) this season — 3rd lowest in MLB; League Avg: .500.

The Astros are just 3-17 (.150) when allowing 5 or more runs this season — 4th lowest in MLB; League Avg: .224.

Orioles Keys to the Game vs. the Astros

The Orioles are just 74-11 (.871) when leading entering the 8th inning since the 2025 season — 4th lowest in MLB; League Avg: .907.

The Orioles are just 2-89 (.022) when trailing entering the 9th inning since the 2025 season — tied for 4th lowest in MLB; League Avg: .045.

The Orioles are just 39-49 (.443) after a win since the 2025 season — 5th lowest in MLB; League Avg: .518.

The Orioles are just 6-10 (.375) when tied entering the 8th inning since the 2025 season — 5th lowest in MLB; League Avg: .500.

Astros Hitting Stats & Trends

Astros hitters have an OBP of .432 (125 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Astros hitters have an OPS of 1.103 (66 PA’s) in lefty-lefty matchups this season — 2nd best in MLB.

Astros hitters are slugging .679 in lefty-lefty matchups this season — best in MLB.

Astros hitters have an OPS of .904 (175 PA’s) in lefty-lefty matchups since the 2025 season — best in MLB.

Orioles Hitting Stats & Trends

Orioles hitters are slugging just .301 on the first pitch of at-bats this season — lowest in MLB.

The Orioles are batting just .220 on the first pitch of at-bats this season — lowest in MLB.

Orioles hitters are slugging just .144 on pitches out of the zone this season — lowest in MLB.

The Orioles are batting just .209 on the road this season — 2nd lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have an ERA of 5.96 (261.1 IP) this season — highest in MLB.

Astros pitchers have walked 13% of batters this season — highest in MLB.

Astros pitchers have an ERA of 6.29 (207.1 IP) this month (24 games) — highest in MLB.

Opponents have a miss rate of 28% against Astros pitchers since the 2025 season — best in MLB.

Orioles Pitching Stats & Trends

Opponents have a miss rate of 28% against Orioles pitchers this season — 3rd best in MLB.

Orioles pitchers have walked 11% of batters when facing the leadoff batter in the inning since the 2025 season — 2nd highest in MLB.

Orioles pitchers have an ERA of 7.00 (27.0 IP) against division opponents this season — 2nd highest in MLB.

Orioles pitchers walked 10% of batters when facing the leadoff batter in the inning in the 2025 season — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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