• The Padres are -125 favorites vs the Astros
• Astros vs Padres Over / Under today: 8 Runs
• Astros / Padres TV Channel: PDTV | SCHN | KFMB

The Houston Astros (+105) visit Petco Park to take on the San Diego Padres (-125) on August 8, 2026. First pitch is scheduled for 7:15 pm in San Diego, CA.

This season, the Astros are 60-57 against the spread (ATS), while the Padres are 61-54 ATS.

Astros vs Padres Starting Pitchers Today:

• Astros starting pitcher: Peter Lambert 8-5, 3.09 ERA
• Padres starting pitcher: Michael King 6-8, 3.46 ERA

Astros vs. Padres Odds, Run Line, Over/Under & Moneyline

Astros vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Saturday‘s MLB game with 57.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Saturday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Taylor Trammell has hit the Home Runs Over in 4 of his last 9 away games (+21.80 Units / 242% ROI)
• Daulton Varsho has hit the RBIs Under in 18 of his last 20 games (+13.20 Units / 27% ROI)
• Taylor Trammell has hit the Runs Over in 11 of his last 20 away games (+10.45 Units / 52% ROI)
• Christian Walker has hit the Hits Over in his last 10 games (+10.00 Units / 58% ROI)
• Yordan Alvarez has hit the Total Bases Under in 15 of his last 20 away games (+9.60 Units / 42% ROI)

And here are some favorite MLB player prop bets for Padres players for Saturday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Gavin Sheets has hit the Hits Under in 15 of his last 20 games (+14.75 Units / 73% ROI)
• Gavin Sheets has hit the Total Bases Under in 16 of his last 20 games (+13.80 Units / 56% ROI)
• Jackson Merrill has hit the RBIs Over in 14 of his last 25 games (+12.90 Units / 52% ROI)
• Luis Campusano has hit the Runs Under in 14 of his last 15 games (+12.20 Units / 41% ROI)
• Gavin Sheets has hit the Walks Over in 8 of his last 10 games at home (+11.45 Units / 114% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Moneyline in 23 of their last 35 away games (+12.40 Units / 34% ROI)
• The Houston Astros have covered the Run Line in 12 of their last 16 games (+11.45 Units / 59% ROI)
• The Houston Astros have hit the Team Total Over in 19 of their last 30 away games (+8.05 Units / 24% ROI)
• The Houston Astros have hit the Game Total Over in 11 of their last 15 away games (+7.70 Units / 47% ROI)
• The Houston Astros have covered the 1st Five Innings (F5) Run Line in 9 of their last 12 games (+5.75 Units / 39% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 28 of their last 45 games at home (+9.50 Units / 18% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 19 games at home (+7.50 Units / 36% ROI)
• The San Diego Padres have hit the Game Total Under in 24 of their last 40 games at home (+6.50 Units / 15% ROI)
• The San Diego Padres have hit the Moneyline in 14 of their last 21 games at home (+5.75 Units / 21% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 11 of their last 18 games at home (+3.65 Units / 18% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 60-57 against the Run Line (-1.55 Units / -0.99% ROI).

• 60-57 when betting on the Moneyline for -1.95 Units / -1.43% ROI
• 63-48 when betting on the total runs Over for +9.25 Units / 7.12% ROI
• 48-63 when betting on the total runs Under for -21.15 Units / -16.59% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 61-54 against the Run Line (+0.8 Units / 0.52% ROI).

• 60-57 when betting on the Moneyline for -0.65 Units / -0.47% ROI
• 54-61 when betting on the total runs Over for -13.15 Units / -10.17% ROI
• 61-54 when betting on the total runs Under for +1.95 Units / 1.52% ROI

Padres vs Astros Home Run Prop Bets Today

Padres vs Astros Total Hits Prop Bets Today

Padres vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Padres

The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.

The Astros were 41-8 (.837) when they hit 2 or more home runs in the 2025 season — best in MLB; League Avg: .699.

The Astros were just 5-13 (.278) when tied entering the 8th inning in the 2024 season — 3rd lowest in MLB; League Avg: .500.

The Astros were 71-4 (.947) when leading entering the 8th inning in the 2025 season — tied for 2nd best in MLB; League Avg: .909.

Padres Keys to the Game vs. the Astros

The Padres were 67-6 (.918) when leading entering the 7th inning in the 2024 season — 4th best in MLB; League Avg: .856.

The Padres were 25-6 (.806) when they hit 2 or more home runs in the 2025 season — 5th best in MLB; League Avg: .699.

The Padres were 13-8 (.619) when tied entering the 7th inning in the 2024 season — 5th best in MLB; League Avg: .498.

The Padres were 11-59 (.157) when trailing entering the 8th inning in the 2024 season — 3rd best in MLB; League Avg: .100.

Astros Hitting Stats & Trends

The Astros are batting .275 when facing the starting pitcher for the 3rd time in a game this season — tied for 5th best in MLB.

The Astros are batting .250 on the road this season — tied for 4th best in MLB.

Astros hitters have struck out in just 21% of their PA’s against LHP this season — 5th best in MLB.

The Astros have scored 235 runs with two outs this season — most in MLB.

Padres Hitting Stats & Trends

The Padres are batting .377 on the first pitch of at-bats this season — 2nd best in MLB.

Padres hitters are slugging just .355 at home this season — 2nd lowest in MLB.

Padres hitters have grounded into 91 double plays in 764 opportunities (12%) this season — highest in MLB.

Padres hitters are slugging .606 on the first pitch of at-bats this season — 5th best in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 11% of batters this season — 2nd highest in MLB.

Astros pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

Opponents have a groundball batting average of .292 against Astros pitchers with runners on base this season — highest in MLB.

Padres Pitching Stats & Trends

Padres pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

Padres pitchers have a strikeout rate of 27% in close and late situations this season — 4th best in MLB.

The Padres pitchers have allowed their opponents to score first in 62% of their games at home this season — 4th highest in MLB.

Opponents have a groundball batting average of .271 against Padres pitchers this season — 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Astros vs Padres and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.