• The Red Sox are -165 favorites vs the Astros
• Astros vs Red Sox Over / Under today: 9 Runs
• Astros / Red Sox TV Channel: NESN | SCHN

The Houston Astros (+140) visit Fenway Park to take on the Boston Red Sox (-165) on May 3, 2026. First pitch is scheduled for 1:35 pm in Boston, MA.

This season, the Astros are 13-21 against the spread (ATS), while the Red Sox are 11-22 ATS.

Astros vs Red Sox Starting Pitchers Today:

• Astros starting pitcher: Cody Bolton 0-1, 5.79 ERA
• Red Sox starting pitcher: Ranger Suarez 2-2, 3.18 ERA

Astros vs. Red Sox Odds, Run Line, Over/Under & Moneyline

Astros vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Sunday‘s MLB game with 57.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Red Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Sunday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Carlos Correa has hit the Hits Over in 18 of his last 25 away games (+13.45 Units / 32% ROI)
• Yordan Alvarez has hit the Runs Under in 18 of his last 25 away games (+11.80 Units / 42% ROI)
• Brice Matthews has hit the Home Runs Over in 2 of his last 5 games (+10.80 Units / 216% ROI)
• Christian Walker has hit the Total Bases Over in 17 of his last 25 away games (+10.75 Units / 38% ROI)
• Jose Altuve has hit the RBIs Under in his last 9 games (+9.00 Units / 41% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

• Carlos Narvaez has hit the Home Runs Over in 2 of his last 5 games (+17.00 Units / 340% ROI)
• Roman Anthony has hit the Runs Under in 19 of his last 25 games (+11.55 Units / 33% ROI)
• Willson Contreras has hit the Walks Under in 17 of his last 20 games (+11.00 Units / 29% ROI)
• Marcelo Mayer has hit the Singles Under in 13 of his last 15 games at home (+10.05 Units / 38% ROI)
• Ceddanne Rafaela has hit the Hits Runs and RBIs Under in 12 of his last 15 games (+8.45 Units / 44% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 21 of their last 30 games (+11.90 Units / 36% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 25 of their last 40 games (+10.05 Units / 22% ROI)
• The Houston Astros have hit the Team Total Over in 20 of their last 35 games (+2.95 Units / 7% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 5 of their last 8 away games (+2.50 Units / 31% ROI)
• The Houston Astros have hit the Moneyline in 4 of their last 8 away games (+0.90 Units / 11% ROI)

Red Sox Best Bets Today:

• The Boston Red Sox have hit the Team Total Under in 30 of their last 45 games at home (+13.75 Units / 27% ROI)
• The Boston Red Sox have hit the Game Total Under in 17 of their last 24 games at home (+11.50 Units / 44% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 25 games at home (+7.55 Units / 23% ROI)
• The Boston Red Sox have covered the Run Line in 4 of their last 7 games (+1.20 Units / 12% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 5 of their last 9 games (+1.00 Units / 10% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 13-21 against the Run Line (-10.6 Units / -24.45% ROI).

• 13-21 when betting on the Moneyline for -11.75 Units / -27.78% ROI
• 23-10 when betting on the total runs Over for +11.6 Units / 30.49% ROI
• 10-23 when betting on the total runs Under for -15.1 Units / -41.03% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 11-22 against the Run Line (-11.4 Units / -29.04% ROI).

• 13-20 when betting on the Moneyline for -11.75 Units / -28.28% ROI
• 16-16 when betting on the total runs Over for -1.75 Units / -4.8% ROI
• 16-16 when betting on the total runs Under for -1.55 Units / -4.28% ROI

Red Sox vs Astros Home Run Prop Bets Today

Red Sox vs Astros Total Hits Prop Bets Today

Red Sox vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Red Sox

The Astros are just 2-14 (.125) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .272.

The Astros are just 13-19 (.406) when allowing 5 or more extra base hits this season — tied for 2nd lowest in MLB; League Avg: .532.

The Astros are just 0-19 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .112.

The Astros are just 5-13 (.278) on the road this season — lowest in MLB; League Avg: .468.

Red Sox Keys to the Game vs. the Astros

The Red Sox are just 0-19 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .058.

The Red Sox are just 6-9 (.400) at home this season — 3rd lowest in MLB; League Avg: .532.

The Red Sox are just 0-18 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .147.

The Red Sox are just 0-18 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .112.

Astros Hitting Stats & Trends

Astros hitters have an OBP of .435 (147 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The Astros are batting .357 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The Astros are batting .289 on the road this season — 2nd best in MLB.

Astros hitters have struck out in just 20% of their PA’s against RHP this season — 3rd best in MLB.

Red Sox Hitting Stats & Trends

Red Sox hitters are slugging just .317 at home this season — lowest in MLB.

Red Sox hitters are slugging just .351 this season — 2nd lowest in MLB.

Red Sox hitters have 39 extra-base hits out of 150 total hits (just 26%) in non-two strike counts this season — lowest in MLB.

Red Sox hitters are slugging just .415 in non-two strike counts this season — lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 14% of batters this season — highest in MLB.

Astros pitchers have an ERA of 5.91 (295.1 IP) this season — highest in MLB.

The Astros have allowed 3.65 runs per game (124/34) in the first 5 innings this season — highest in MLB.

Astros pitchers have an ERA of 6.53 (150.1 IP) on the road this season — highest in MLB.

Red Sox Pitching Stats & Trends

Red Sox pitchers have walked 5% of batters when facing the leadoff batter in the inning this season — best in MLB.

Opponents have a groundball batting average of just .198 against Red Sox pitchers this season — best in MLB.

Opponents have a groundball batting average of just .178 against Red Sox pitchers with runners on base this season — best in MLB.

Red Sox pitchers have 37 three-pitch strikeouts this season — 4th fewest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Astros vs Red Sox and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.