• The Reds are -125 favorites vs the Astros
• Astros vs Reds Over / Under today: 9 Runs
• Astros / Reds TV Channel: RDTV | SCHN

The Houston Astros (+105) visit Great American Ball Park to take on the Cincinnati Reds (-125) on May 10, 2026. First pitch is scheduled for 1:40 pm in Cincinnati, OH.

This season, the Astros are 16-24 against the spread (ATS), while the Reds are 24-15 ATS.

Astros vs Reds Starting Pitchers Today:

• Astros starting pitcher: Kai-Wei Teng 1-2, 2.35 ERA
• Reds starting pitcher: Andrew Abbott 1-2, 5.22 ERA

Astros vs. Reds Odds, Run Line, Over/Under & Moneyline

Astros vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Reds will win Sunday‘s MLB game with 51.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Reds and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Sunday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Brice Matthews has hit the Home Runs Over in 3 of his last 10 games (+12.90 Units / 129% ROI)
• Isaac Paredes has hit the Total Bases Over in 13 of his last 15 away games (+11.90 Units / 58% ROI)
• Yordan Alvarez has hit the Runs Under in 17 of his last 25 away games (+9.75 Units / 35% ROI)
• Isaac Paredes has hit the Hits Over in 13 of his last 15 away games (+9.60 Units / 36% ROI)
• Yordan Alvarez has hit the Walks Under in 15 of his last 20 games (+8.40 Units / 31% ROI)

And here are some favorite MLB player prop bets for Reds players for Sunday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

• Nate Lowe has hit the Home Runs Over in 4 of his last 8 games at home (+18.30 Units / 229% ROI)
• Tyler Stephenson has hit the Runs Under in 19 of his last 20 games (+17.45 Units / 44% ROI)
• TJ Friedl has hit the Walks Under in 17 of his last 20 games (+11.90 Units / 33% ROI)
• Sal Stewart has hit the Hits Runs and RBIs Under in 13 of his last 15 games (+11.35 Units / 66% ROI)
• Spencer Steer has hit the Total Bases Over in 18 of his last 25 games (+10.30 Units / 29% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 26 of their last 40 games (+11.10 Units / 25% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 28 of their last 45 games (+10.55 Units / 21% ROI)
• The Houston Astros have hit the Team Total Under in 8 of their last 11 games (+3.90 Units / 28% ROI)
• The Houston Astros have hit the Moneyline in 4 of their last 6 away games (+3.00 Units / 50% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 6 of their last 11 away games (+1.55 Units / 14% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Game Total Over in 21 of their last 30 games (+10.95 Units / 33% ROI)
• The Cincinnati Reds have hit the Team Total Under in 16 of their last 24 games at home (+6.80 Units / 23% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 16 of their last 24 games at home (+6.25 Units / 20% ROI)
• The Cincinnati Reds have covered the Run Line in 15 of their last 24 games (+5.30 Units / 15% ROI)
• The Cincinnati Reds have hit the Moneyline in 18 of their last 30 games at home (+3.40 Units / 9% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 16-24 against the Run Line (-10.95 Units / -21.43% ROI).

• 16-24 when betting on the Moneyline for -10.3 Units / -21.33% ROI
• 26-13 when betting on the total runs Over for +11.1 Units / 24.69% ROI
• 13-26 when betting on the total runs Under for -15.3 Units / -35.5% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 24-15 against the Run Line (+4.65 Units / 7.88% ROI).

• 21-19 when betting on the Moneyline for +2 Units / 4.42% ROI
• 24-15 when betting on the total runs Over for +7.4 Units / 16.78% ROI
• 15-24 when betting on the total runs Under for -11.4 Units / -25.97% ROI

Reds vs Astros Home Run Prop Bets Today

Reds vs Astros Total Hits Prop Bets Today

Reds vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Reds

The Astros are just 0-21 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

The Astros are just 16-21 (.432) when allowing 5 or more extra base hits this season — 4th lowest in MLB; League Avg: .532.

The Astros are just 16-24 (.400) this season — tied for 4th lowest in MLB; League Avg: .500.

The Astros are just 3-12 (.200) when their opponents score in the first inning this season — 3rd lowest in MLB; League Avg: .371.

Reds Keys to the Game vs. the Astros

The Reds are 3-17 (.150) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .051.

The Reds are 4-13 (.235) when trailing entering the 7th inning this season — 4th best in MLB; League Avg: .138.

The Reds are just 12-46 (.207) when allowing 10 or more hits since the 2025 season — 5th lowest in MLB; League Avg: .254.

The Reds are just 10-65 (.133) when allowing 5 or more runs since the 2025 season — 5th lowest in MLB; League Avg: .204.

Astros Hitting Stats & Trends

Astros hitters have an OBP of .417 (168 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The Astros are batting .285 on the road this season — 2nd best in MLB.

The Astros are batting .338 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

31% of Astros hitters strikeouts have come on 95+ MPH fastballs this season — 3rd highest in MLB.

Reds Hitting Stats & Trends

Reds hitters have an OBP of just .280 (661 PA’s) with runners on base this season — lowest in MLB.

The Reds are batting just .196 with runners on base this season — lowest in MLB.

The Reds are batting just .218 this season — lowest in MLB.

The Reds are batting just .185 with two outs this season — 2nd lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 13% of batters this season — highest in MLB.

Astros pitchers have an ERA of 5.56 (349.1 IP) this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — lowest in MLB.

Astros pitchers have allowed three-ball counts to 25% of batters they faced (396/1,580 PA’s) this season — highest in MLB.

Reds Pitching Stats & Trends

Reds pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Reds pitchers have walked 12% of batters this season — 2nd highest in MLB.

Reds pitchers have thrown at least two strikes in their first three pitches to 57% of opposing batters this season — 2nd lowest in MLB.

Reds pitchers have a first-pitch strike rate of just 56% this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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