• The Astros are -105 favorites vs the Twins
• Astros vs Twins Over / Under today: 9.5 Runs
• Astros / Twins TV Channel: TWTV | SCHN

The Houston Astros (-105) visit Target Field to take on the Minnesota Twins (-115) on May 18, 2026. First pitch is scheduled for 7:40 pm in Minneapolis, MN.

This season, the Astros are 19-29 against the spread (ATS), while the Twins are 25-22 ATS.

Astros vs Twins Starting Pitchers Today:

• Astros starting pitcher: Tatsuya Imai 1-1, 9.50 ERA
• Twins starting pitcher: Kendry Rojas 1-0, 2.57 ERA

Astros vs. Twins Odds, Run Line, Over/Under & Moneyline

Astros vs Twins Prediction for Today’s Game

Based on recent trends the model predicts the Twins will win Monday‘s MLB game with 51.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Twins and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Monday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Cam Smith has hit the Hits Under in 18 of his last 25 games (+15.40 Units / 61% ROI)
• Cam Smith has hit the Total Bases Under in 18 of his last 25 games (+13.50 Units / 47% ROI)
• Cam Smith has hit the Singles Under in 20 of his last 25 games (+12.35 Units / 33% ROI)
• Christian Vazquez has hit the Home Runs Over in 2 of his last 10 away games (+12.00 Units / 120% ROI)
• Cam Smith has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+11.70 Units / 34% ROI)

And here are some favorite MLB player prop bets for Twins players for Monday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Best Bets Today:

• Josh Bell has hit the Runs Under in 21 of his last 25 games (+14.00 Units / 32% ROI)
• Ryan Jeffers has hit the Home Runs Over in 3 of his last 8 games at home (+13.60 Units / 170% ROI)
• Austin Martin has hit the Walks Over in 15 of his last 25 games (+11.05 Units / 44% ROI)
• Ryan Jeffers has hit the Total Bases Over in 17 of his last 25 games (+10.45 Units / 31% ROI)
• Trevor Larnach has hit the Hits Over in 19 of his last 25 games (+9.70 Units / 23% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Team Total Under in 14 of their last 17 games (+10.00 Units / 47% ROI)
• The Houston Astros have hit the Game Total Over in 27 of their last 45 games (+8.60 Units / 17% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 30 of their last 50 away games (+8.15 Units / 14% ROI)
• The Houston Astros have hit the Moneyline in 4 of their last 7 away games (+1.90 Units / 27% ROI)
• The Houston Astros have covered the Run Line in 3 of their last 5 away games (+0.50 Units / 7% ROI)

Twins Best Bets Today:

• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 18 of their last 23 games at home (+12.40 Units / 43% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 17 of their last 23 games at home (+11.50 Units / 43% ROI)
• The Minnesota Twins have hit the Game Total Over in 27 of their last 45 games (+10.25 Units / 21% ROI)
• The Minnesota Twins have hit the Team Total Over in 28 of their last 45 games (+8.75 Units / 16% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 23 games at home (+8.35 Units / 30% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 19-29 against the Run Line (-14.45 Units / -23.33% ROI).

• 19-29 when betting on the Moneyline for -12.05 Units / -21.29% ROI
• 28-18 when betting on the total runs Over for +7.3 Units / 13.48% ROI
• 18-28 when betting on the total runs Under for -12.4 Units / -24.08% ROI

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 25-22 against the Run Line (-5.95 Units / -8.66% ROI).

• 21-26 when betting on the Moneyline for -3.35 Units / -6.75% ROI
• 27-17 when betting on the total runs Over for +8.05 Units / 15.48% ROI
• 17-27 when betting on the total runs Under for -12.65 Units / -24.61% ROI

Twins vs Astros Home Run Prop Bets Today

Twins vs Astros Total Hits Prop Bets Today

Twins vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Twins

The Astros are just 0-25 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .134.

The Astros are just 1-17 (.056) when allowing 10 or more hits this season — lowest in MLB; League Avg: .244.

The Astros are just 19-25 (.432) when allowing 5 or more extra base hits this season — 3rd lowest in MLB; League Avg: .532.

The Astros are just 4-13 (.235) when their opponents score in the first inning this season — tied for 4th lowest in MLB; League Avg: .362.

Twins Keys to the Game vs. the Astros

The Twins are just 18-4 (.818) when leading entering the 8th inning this season — 3rd lowest in MLB; League Avg: .895.

The Twins are just 2-18 (.100) when allowing 5 or more runs this season — 3rd lowest in MLB; League Avg: .207.

The Twins are just 2-9 (.182) when allowing 2 or more home runs this season — 5th lowest in MLB; League Avg: .295.

The Twins are just 0-22 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

Astros Hitting Stats & Trends

The Astros are batting .278 on the road this season — 2nd best in MLB.

The Astros are batting .314 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Astros hitters have an OBP of .348 (870 PA’s) on the road this season — 2nd best in MLB.

Astros hitters are slugging .416 against RHP this season — 5th best in MLB.

Twins Hitting Stats & Trends

The Twins are batting just .192 with two outs this season — 2nd lowest in MLB.

Twins hitters have 26 extra-base hits out of 52 total hits (50%) on the first pitch of at-bats this season — best in MLB.

Twins hitters have struck out in 35% of their PA’s in lefty-lefty matchups this season — highest in MLB.

Twins hitters have an OBP of .351 (595 PA’s) against LHP this season — 3rd best in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 13% of batters this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

Astros pitchers have an ERA of 5.43 (421.1 IP) this season — highest in MLB.

Astros pitchers have a first-pitch strike rate of just 57% this season — 3rd lowest in MLB.

Twins Pitching Stats & Trends

Opponents have a miss rate of just 22% against Twins pitchers this season — tied for 2nd lowest in MLB.

Opponents have a groundball rate of just 40% against Twins pitchers this season — 3rd lowest in MLB.

Twins pitchers have a strikeout rate of just 19% with runners in scoring position this season — 4th lowest in MLB.

Twins pitchers have a strikeout rate of just 17% in close and late situations this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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