Athletics vs Mariners Prediction, Odds & Player Prop Bets Today – MLB, Apr 22

Seattle Mariners left fielder Randy Arozarena throws to the infield during the third inning of a spring training baseball game against the Colorado Rockies Sunday, March 2, 2025, in Scottsdale, Ariz.
(AP Photo/Ross D. Franklin)
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  • The Mariners are -190 favorites vs the Athletics
  • Athletics vs Mariners Over / Under today: 7.5 Runs
  • Athletics / Mariners TV Channel: MRTV | NSCA

The Athletics (+155) visit T-Mobile Park to take on the Seattle Mariners (-190) on April 22, 2026. First pitch is scheduled for 4:10 pm in Seattle, WA.

This season, the Athletics are 13-11 against the spread (ATS), while the Mariners are 9-16 ATS.

Athletics vs Mariners Starting Pitchers Today:

  • Athletics starting pitcher: , ERA
  • Mariners starting pitcher: , ERA

Athletics vs. Mariners Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Athletics+1.5 -145O 7.5 -115+155
Mariners -1.5 +118U 7.5 -105-190

Athletics vs Mariners Prediction for Today’s Game

Based on recent trends the model predicts the will win Wednesday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Athletics players for Wednesday‘s game, looking at profitable historical betting trends:

Best Athletics Player Prop Bets Today:

  • player high – away 

And here are some favorite MLB player prop bets for Mariners players for Wednesday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Best Bets Today:

  • player  high – home
  • team high – away
  • team high – home

Athletics Against the Spread (ATS) Record

Against the spread this season, the Athletics are 14-10 against the Run Line (+0.55 Units / 1.61% ROI).

  • 13-11 when betting on the Moneyline for +4.2 Units / 16.03% ROI
  • 12-11 when betting on the total runs Over for -0.1 Units / -0.38% ROI
  • 11-12 when betting on the total runs Under for -2.1 Units / -7.98% ROI

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are 9-16 against the Run Line (-5.45 Units / -20.07% ROI).

  • 10-15 when betting on the Moneyline for -10.25 Units / -29.04% ROI
  • 11-14 when betting on the total runs Over for -4.3 Units / -15.66% ROI
  • 14-11 when betting on the total runs Under for +1.95 Units / 7.07% ROI

Mariners vs Athletics Home Run Prop Bets Today

Yes
Cal Raleigh +270
Shea Langeliers +340
Julio Rodriguez +350
Nick Kurtz +400
Luke Raley +425

Mariners vs Athletics Total Hits Prop Bets Today

Over Under
Julio Rodriguez 0.5 -250 0.5 +180
Jacob Wilson 0.5 -210 0.5 +155
Josh Naylor 0.5 -190 0.5 +140
J.P. Crawford 0.5 -185 0.5 +135
Randy Arozarena 0.5 -160 0.5 +120

Mariners vs Athletics Strikeout Prop Bets Today

Over Under
Leo Rivas 0.5 -235 0.5 +175
Randy Arozarena 0.5 -175 0.5 +130
J.P. Crawford 0.5 -175 0.5 +130
Julio Rodriguez 0.5 -165 0.5 +125
Dominic Canzone 0.5 -160 0.5 +120

Athletics Keys to the Game vs. the Mariners

Mariners Keys to the Game vs. the Athletics

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.