- The Padres are -135 favorites vs the Athletics
- Athletics vs Padres Over / Under today: 8 Runs
- Athletics / Padres TV Channel: NSCA | PDTV
The Athletics (+110) visit Petco Park to take on the San Diego Padres (-135) on May 22, 2026. First pitch is scheduled for 9:40 pm in San Diego, CA.
This season, the Athletics are 26-24 against the spread (ATS), while the Padres are 27-21 ATS.
Athletics vs Padres Starting Pitchers Today:
- Athletics starting pitcher: , ERA
- Padres starting pitcher: , ERA
Athletics vs. Padres Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Athletics | +1.5 -190 | O 8 -110 | +110 |
| Padres | -1.5 +155 | U 8 -110 | -135 |
Athletics vs Padres Prediction for Today’s Game
Based on recent trends the model predicts the will win Friday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
Bet now on Athletics vs Padres and all games with BetMGM
We’ve highlighted some favorite MLB player prop bets for Athletics players for Friday‘s game, looking at profitable historical betting trends:
Best Athletics Player Prop Bets Today:
- player high – away
And here are some favorite MLB player prop bets for Padres players for Friday‘s game, looking at profitable historical betting trends:
Best Padres Player Prop Best Bets Today:
- player high – home
Athletics Best Bets Today:
- team high – away
Padres Best Bets Today:
- team high – home
Athletics Against the Spread (ATS) Record
Against the spread this season, the Athletics are 28-22 against the Run Line (+2.5 Units / 3.68% ROI).
- 26-24 when betting on the Moneyline for +2.25 Units / 3.99% ROI
- 23-25 when betting on the total runs Over for -4.3 Units / -7.82% ROI
- 25-23 when betting on the total runs Under for -0.1 Units / -0.18% ROI
Padres Against the Spread (ATS) Record
Against the spread this season, the Padres are 27-21 against the Run Line (+3.35 Units / 5.09% ROI).
- 29-20 when betting on the Moneyline for +7.2 Units / 11.83% ROI
- 21-26 when betting on the total runs Over for -7.4 Units / -13.72% ROI
- 26-21 when betting on the total runs Under for +3 Units / 5.56% ROI
Padres vs Athletics Home Run Prop Bets Today
| Yes | |
|---|---|
| Shea Langeliers | +310 |
| Manny Machado | +360 |
| Nick Kurtz | +375 |
| Brent Rooker | +400 |
| Ramon Laureano | +475 |
Padres vs Athletics Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Xander Bogaerts | 0.5 -235 | 0.5 +175 |
| Carlos Cortes | 0.5 -235 | 0.5 +175 |
| Shea Langeliers | 0.5 -225 | 0.5 +165 |
| Miguel Andujar | 0.5 -225 | 0.5 +165 |
| Fernando Tatis Jr. | 0.5 -210 | 0.5 +150 |
Padres vs Athletics Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Ramon Laureano | 0.5 -275 | 0.5 +195 |
| Shea Langeliers | 0.5 -250 | 0.5 +180 |
| Tyler Soderstrom | 0.5 -210 | 0.5 +155 |
| Fernando Tatis Jr. | 0.5 -200 | 0.5 +150 |
| Nicholas Castellanos | 0.5 -165 | 0.5 +125 |
Athletics Keys to the Game vs. the Padres
Padres Keys to the Game vs. the Athletics
Athletics Hitting Stats & Trends
Padres Hitting Stats & Trends
Athletics Pitching Stats & Trends
Padres Pitching Stats & Trends
More MLB Reading:
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