• The Angels are -120 favorites vs the Cardinals
• Cardinals vs Angels Over / Under today: 8.5 Runs
• Cardinals / Angels TV Channel: CATV | ABTV

The St. Louis Cardinals (+100) visit Angel Stadium of Anaheim to take on the Los Angeles Angels (-120) on July 22, 2026. First pitch is scheduled for 4:07 pm in Anaheim, CA.

This season, the Cardinals are 51-49 against the spread (ATS), while the Angels are 51-50 ATS.

Cardinals vs Angels Starting Pitchers Today:

• Cardinals starting pitcher: Hunter Dobbins 1-1, 4.03 ERA
• Angels starting pitcher: Reid Detmers 3-6, 4.22 ERA

Cardinals vs. Angels Odds, Run Line, Over/Under & Moneyline

Cardinals vs Angels Prediction for Today’s Game

Based on recent trends the model predicts the Angels will win Wednesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Ivan Herrera has hit the Total Bases Under in 20 of his last 25 games (+12.50 Units / 29% ROI)
• Jordan Walker has hit the Hits Runs and RBIs Over in 16 of his last 20 games (+10.70 Units / 42% ROI)
• Ivan Herrera has hit the Hits Under in 14 of his last 25 games (+10.20 Units / 35% ROI)
• Masyn Winn has hit the Runs Under in 13 of his last 15 games (+9.80 Units / 31% ROI)
• Michael McGreevy has hit the Earned Runs Under in 18 of his last 25 games (+9.75 Units / 32% ROI)

And here are some favorite MLB player prop bets for Angels players for Wednesday‘s game, looking at profitable historical betting trends:

Best Angels Player Prop Best Bets Today:

• Logan O’Hoppe has hit the Runs Under in 20 of his last 25 games at home (+10.60 Units / 20% ROI)
• Denzer Guzman has hit the Singles Over in 11 of his last 15 games (+8.90 Units / 58% ROI)
• Jo Adell has hit the Hits Under in 10 of his last 15 games (+8.75 Units / 58% ROI)
• Mike Trout has hit the Walks Over in 14 of his last 20 games at home (+8.50 Units / 37% ROI)
• Logan O’Hoppe has hit the Hits Runs and RBIs Under in 14 of his last 20 games (+8.20 Units / 31% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Team Total Over in 30 of their last 45 away games (+13.35 Units / 25% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 30 of their last 50 games (+10.30 Units / 19% ROI)
• The St. Louis Cardinals have covered the Run Line in 27 of their last 45 away games (+7.40 Units / 11% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 18 of their last 35 away games (+7.30 Units / 20% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 20 away games (+6.65 Units / 29% ROI)

Angels Best Bets Today:

• The Los Angeles Angels have hit the Game Total Under in 28 of their last 45 games at home (+10.55 Units / 21% ROI)
• The Los Angeles Angels have hit the 1st Five Innings (F5) Moneyline in 27 of their last 50 games at home (+7.75 Units / 13% ROI)
• The Los Angeles Angels have hit the Team Total Under in 14 of their last 20 games (+7.45 Units / 31% ROI)
• The Los Angeles Angels have covered the 1st Five Innings (F5) Run Line in 27 of their last 45 games (+7.40 Units / 14% ROI)
• The Los Angeles Angels have hit the 1st Five Innings (F5) Team Total Under in 5 of their last 6 games (+3.90 Units / 47% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 56-41 against the Run Line (+3 Units / 2.11% ROI).

• 51-49 when betting on the Moneyline for +6.1 Units / 5.7% ROI
• 41-54 when betting on the total runs Over for -18.65 Units / -16.92% ROI
• 54-41 when betting on the total runs Under for +8.75 Units / 7.96% ROI

Angels Against the Spread (ATS) Record

Against the spread this season, the Angels are 51-50 against the Run Line (-12.05 Units / -8.69% ROI).

• 41-61 when betting on the Moneyline for -14.45 Units / -13.29% ROI
• 46-54 when betting on the total runs Over for -13.1 Units / -11.62% ROI
• 54-46 when betting on the total runs Under for +4.15 Units / 3.72% ROI

Cardinals Keys to the Game vs. the Angels

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

Angels Keys to the Game vs. the Cardinals

The Angels are just 39-55 (.415) when allowing 5 or more extra base hits this season — lowest in MLB; League Avg: .535.

The Angels are just 34-8 (.810) when leading entering the 9th inning this season — lowest in MLB; League Avg: .947.

The Angels are just 3-10 (.231) when tied entering the 8th inning this season — 2nd lowest in MLB; League Avg: .500.

The Angels are just 41-61 (.402) this season — 2nd lowest in MLB; League Avg: .500.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

The Cardinals have answered-back in just 19% of innings after an opponent scores in late innings this season — lowest in MLB.

Cardinals hitters are slugging just .366 at home this season — 3rd lowest in MLB.

Cardinals hitters have an OBP of .330 (1,902 PA’s) on the road this season — 3rd best in MLB.

Angels Hitting Stats & Trends

Angels hitters have struck out in 25% of their PA’s against RHP this season — highest in MLB.

The Angels have a winning percentage of just 33% on the road this season — tied for lowest in MLB.

Angels hitters have struck out in 26% of their PA’s against LHP this season — highest in MLB.

Angels hitters have struck out in 25% of their PA’s this season — highest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 22% against Cardinals pitchers this season — tied for lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 3rd highest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Cardinals pitchers have allowed an average Exit Velocity of 89.8 MPH (2,615 batted balls) this season — tied for highest in MLB.

Angels Pitching Stats & Trends

Angels pitchers have walked 11% of batters this season — 3rd highest in MLB.

The Angels pitchers have allowed their opponents to score first in 59% of their games on the road this season — 2nd highest in MLB.

Opponents have a miss rate of 28% against Angels pitchers this season — best in MLB.

Angels pitchers have won only 16% of games in which they have allowed their opponent to score in three different innings this season — tied for lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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