• The Astros are -145 favorites vs the Cardinals
• Cardinals vs Astros Over / Under today: 9 Runs
• Cardinals / Astros TV Channel: CATV | SCHN

The St. Louis Cardinals (+118) visit Daikin Park to take on the Houston Astros (-145) on April 18, 2026. First pitch is scheduled for 7:10 pm in Houston, TX.

This season, the Cardinals are 11-8 against the spread (ATS), while the Astros are 8-13 ATS.

Cardinals vs Astros Starting Pitchers Today:

• Cardinals starting pitcher: Andre Pallante 1-1, 4.70 ERA
• Astros starting pitcher: Lance McCullers 1-0, 5.87 ERA

Cardinals vs. Astros Odds, Run Line, Over/Under & Moneyline

Cardinals vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Saturday‘s MLB game with 59.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Astros and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Home Runs Over in 6 of his last 10 games (+28.50 Units / 285% ROI)
• Ivan Herrera has hit the Walks Over in 12 of his last 15 games (+14.85 Units / 99% ROI)
• Jordan Walker has hit the Runs Over in 16 of his last 25 games (+14.80 Units / 59% ROI)
• Andre Pallante has hit the Pitching Outs Under in 18 of his last 25 games (+10.80 Units / 37% ROI)
• Jordan Walker has hit the RBIs Over in 7 of his last 10 games (+8.55 Units / 86% ROI)

And here are some favorite MLB player prop bets for Astros players for Saturday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

• Yordan Alvarez has hit the Runs Over in 14 of his last 15 games at home (+13.30 Units / 72% ROI)
• Yordan Alvarez has hit the Home Runs Over in 5 of his last 10 games at home (+11.80 Units / 118% ROI)
• Yordan Alvarez has hit the Hits Runs and RBIs Over in 13 of his last 15 games at home (+11.05 Units / 61% ROI)
• Christian Walker has hit the Total Bases Over in 17 of his last 25 games (+9.45 Units / 32% ROI)
• Carlos Correa has hit the Hits Over in 16 of his last 20 games at home (+8.50 Units / 20% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 18 of their last 30 away games (+6.90 Units / 21% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 15 of their last 22 away games (+6.45 Units / 24% ROI)
• The St. Louis Cardinals have hit the Team Total Over in their last 6 away games (+6.15 Units / 88% ROI)
• The St. Louis Cardinals have hit the Moneyline in 16 of their last 30 games (+4.30 Units / 14% ROI)
• The St. Louis Cardinals have covered the Run Line in 3 of their last 5 away games (+2.35 Units / 35% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 25 games (+10.80 Units / 38% ROI)
• The Houston Astros have hit the Game Total Over in 14 of their last 19 games (+8.20 Units / 38% ROI)
• The Houston Astros have hit the Team Total Under in 29 of their last 50 games at home (+4.75 Units / 8% ROI)
• The Houston Astros have covered the Run Line in 6 of their last 9 games at home (+4.40 Units / 44% ROI)
• The Houston Astros have hit the Moneyline in 7 of their last 9 games at home (+4.40 Units / 34% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 10-8 against the Run Line (-1.3 Units / -4.7% ROI).

• 11-8 when betting on the Moneyline for +4.25 Units / 21.68% ROI
• 11-7 when betting on the total runs Over for +3.4 Units / 16.5% ROI
• 7-11 when betting on the total runs Under for -5.4 Units / -25.35% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 8-13 against the Run Line (-4.85 Units / -19.88% ROI).

• 8-13 when betting on the Moneyline for -9.05 Units / -31.7% ROI
• 14-7 when betting on the total runs Over for +5.9 Units / 24.84% ROI
• 7-14 when betting on the total runs Under for -8.15 Units / -36.3% ROI

Astros vs Cardinals Home Run Prop Bets Today

Astros vs Cardinals Total Hits Prop Bets Today

Astros vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Astros

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 71-4 (.947) when leading entering the 8th inning since the 2025 season — 4th best in MLB; League Avg: .908.

The Cardinals are 149-5 (.968) when leading entering the 9th inning since the 2024 season — tied for 3rd best in MLB; League Avg: .953.

The Cardinals are 135-8 (.944) when leading entering the 8th inning since the 2024 season — 2nd best in MLB; League Avg: .904.

Astros Keys to the Game vs. the Cardinals

The Astros are just 1-9 (.100) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .284.

The Astros are just 0-11 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .127.

The Astros were 41-8 (.837) when they hit 2 or more home runs in the 2025 season — best in MLB; League Avg: .699.

The Astros are just 0-11 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .048.

Cardinals Hitting Stats & Trends

Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

The Cardinals are batting just .168 with two outs this season — 2nd lowest in MLB.

Cardinals hitters have chased 24% of pitches out of the zone against LHP this season — tied for 2nd lowest in MLB.

The Cardinals are batting just .215 with two outs since the 2025 season — tied for lowest in MLB.

Astros Hitting Stats & Trends

Astros hitters are slugging .794 in lefty-lefty matchups this season — best in MLB.

Astros hitters have an OPS of 1.258 (41 PA’s) in lefty-lefty matchups this season — best in MLB.

Astros hitters have struck out in just 6% of their PA’s against LHP over the past seven days (4 games) — best in MLB.

Astros hitters chased 21% of pitches out of the zone on the first pitch of at-bats in the 2025 season — tied for highest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 32% with two-strikes this season — lowest in MLB.

Opponents have a miss rate of just 19% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 15% with runners in scoring position this season — lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 14% of batters this season — highest in MLB.

Astros pitchers have an ERA of 7.98 (82.1 IP) on the road this season — highest in MLB.

The Astros have allowed 4.24 runs per game (89/21) in the first 5 innings this season — highest in MLB.

Astros pitchers have an ERA of 6.15 (181.1 IP) this season — highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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