• The Astros are -150 favorites vs the Cardinals
• Cardinals vs Astros Over / Under today: 8.5 Runs
• Cardinals / Astros TV Channel: CATV | SCHN

The St. Louis Cardinals (+125) visit Daikin Park to take on the Houston Astros (-150) on April 19, 2026. First pitch is scheduled for 2:10 pm in Houston, TX.

This season, the Cardinals are 12-8 against the spread (ATS), while the Astros are 8-14 ATS.

Cardinals vs Astros Starting Pitchers Today:

• Cardinals starting pitcher: Matthew Liberatore 0-1, 4.29 ERA
• Astros starting pitcher: Michael Burrows 1-3, 6.55 ERA

Cardinals vs. Astros Odds, Run Line, Over/Under & Moneyline

Cardinals vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Sunday‘s MLB game with 57.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Astros and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Home Runs Over in 5 of his last 10 away games (+22.60 Units / 226% ROI)
• Jordan Walker has hit the Runs Over in 15 of his last 25 games (+12.30 Units / 49% ROI)
• Alec Burleson has hit the Hits Over in 8 of his last 9 games (+9.55 Units / 63% ROI)
• Jordan Walker has hit the Hits Runs and RBIs Over in 16 of his last 25 games (+7.15 Units / 25% ROI)
• Alec Burleson has hit the Walks Over in 5 of his last 7 away games (+6.95 Units / 99% ROI)

And here are some favorite MLB player prop bets for Astros players for Sunday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

• Yordan Alvarez has hit the Home Runs Over in 5 of his last 8 games at home (+14.35 Units / 179% ROI)
• Yordan Alvarez has hit the Runs Over in 14 of his last 15 games at home (+13.30 Units / 72% ROI)
• Yordan Alvarez has hit the Hits Runs and RBIs Over in 13 of his last 15 games at home (+11.05 Units / 61% ROI)
• Isaac Paredes has hit the Singles Under in 13 of his last 15 games at home (+10.15 Units / 46% ROI)
• Christian Walker has hit the Hits Under in 7 of his last 8 games (+9.25 Units / 116% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 26 of their last 45 away games (+8.35 Units / 17% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 23 away games (+7.45 Units / 26% ROI)
• The St. Louis Cardinals have hit the Team Total Over in their last 7 away games (+7.25 Units / 91% ROI)
• The St. Louis Cardinals have hit the Moneyline in 12 of their last 20 games (+5.45 Units / 26% ROI)
• The St. Louis Cardinals have covered the Run Line in 4 of their last 6 away games (+3.35 Units / 40% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Game Total Over in 15 of their last 20 games (+9.20 Units / 41% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 25 games (+8.65 Units / 31% ROI)
• The Houston Astros have hit the Team Total Over in 13 of their last 20 games at home (+5.35 Units / 22% ROI)
• The Houston Astros have covered the Run Line in 6 of their last 10 games at home (+3.40 Units / 31% ROI)
• The Houston Astros have hit the Moneyline in 7 of their last 10 games at home (+3.00 Units / 21% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 11-8 against the Run Line (-0.3 Units / -1.02% ROI).

• 12-8 when betting on the Moneyline for +5.45 Units / 26.46% ROI
• 12-7 when betting on the total runs Over for +4.4 Units / 20.28% ROI
• 7-12 when betting on the total runs Under for -6.5 Units / -29.02% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 8-14 against the Run Line (-5.85 Units / -23.03% ROI).

• 8-14 when betting on the Moneyline for -10.45 Units / -34.89% ROI
• 15-7 when betting on the total runs Over for +6.9 Units / 27.77% ROI
• 7-15 when betting on the total runs Under for -9.25 Units / -39.28% ROI

Astros vs Cardinals Home Run Prop Bets Today

Astros vs Cardinals Total Hits Prop Bets Today

Astros vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Astros

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 5-3 (.625) on the road this season — tied for 4th best in MLB; League Avg: .447.

The Cardinals are 136-8 (.944) when leading entering the 8th inning since the 2024 season — 2nd best in MLB; League Avg: .904.

The Cardinals are 72-4 (.947) when leading entering the 8th inning since the 2025 season — 4th best in MLB; League Avg: .908.

Astros Keys to the Game vs. the Cardinals

The Astros are just 8-13 (.381) when allowing 5 or more extra base hits this season — 3rd lowest in MLB; League Avg: .522.

The Astros are just 0-13 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .105.

The Astros are just 2-132 (.015) when trailing entering the 9th inning since the 2024 season — 2nd lowest in MLB; League Avg: .047.

The Astros are just 1-9 (.100) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .287.

Cardinals Hitting Stats & Trends

Cardinals hitters have an OBP of .403 (181 PA’s) when leading off an inning this season — best in MLB.

The Cardinals are batting just .164 with two outs this season — 2nd lowest in MLB.

Cardinals hitters have 17 extra-base hits out of 84 total hits (just 20%) against starting pitchers this season — lowest in MLB.

Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

Astros Hitting Stats & Trends

Astros hitters have struck out in just 4% of their PA’s against LHP over the past seven days (3 games) — best in MLB.

The Astros batted .253 with two outs in the 2025 season — 2nd best in MLB.

Astros hitters have an OBP of .355 (626 PA’s) against RHP this season — 2nd best in MLB.

Astros hitters have an OBP of .352 (864 PA’s) this season — 2nd best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 20% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 33% with two-strikes this season — lowest in MLB.

Cardinals pitchers had a strikeout rate of just 20% in the 2025 season — 2nd lowest in MLB.

Astros Pitching Stats & Trends

The Astros have allowed 4.23 runs per game (93/22) in the first 5 innings this season — highest in MLB.

Astros pitchers have an ERA of 6.19 (190.1 IP) this season — highest in MLB.

The Astros have allowed 7.50 runs per game (75/10) on the road this season — highest in MLB.

Astros pitchers have walked 14% of batters this season — highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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