Cardinals vs Brewers Prediction, Odds & Player Prop Bets Today – MLB, May 25

Milwaukee Brewers' William Contreras hits a two-run home run during the second inning of a baseball game against the San Francisco Giants Sunday, May 28, 2023, in Milwaukee. (AP Photo/Morry Gash)
(AP Photo/Morry Gash)
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  • The Brewers are -225 favorites vs the Cardinals
  • Cardinals vs Brewers Over / Under today: 7.5 Runs
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The St. Louis Cardinals (+185) visit American Family Field to take on the Milwaukee Brewers (-225) on May 25, 2026. First pitch is scheduled for 2:10 pm in Milwaukee, WI.

This season, the Cardinals are 29-22 against the spread (ATS), while the Brewers are 30-20 ATS.

Cardinals vs Brewers Starting Pitchers Today:

  • Cardinals starting pitcher: Matthew Liberatore 2-2, 4.71 ERA
  • Brewers starting pitcher: Jacob Misiorowski 4-2, 1.87 ERA

Cardinals vs. Brewers Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals+1.5 -110O 7.5 -105+185
Brewers -1.5 -110U 7.5 -115-225

Cardinals vs Brewers Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Monday‘s MLB game with 71.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Victor Scott II has hit the Home Runs Over in 2 of his last 9 away games (+22.00 Units / 244% ROI)
  • Jordan Walker has hit the Runs Over in 16 of his last 25 away games (+11.90 Units / 46% ROI)
  • Alec Burleson has hit the Hits Over in 15 of his last 20 away games (+11.10 Units / 31% ROI)
  • Victor Scott II has hit the Singles Under in 13 of his last 15 away games (+9.50 Units / 37% ROI)
  • Ivan Herrera has hit the Hits Runs and RBIs Over in 15 of his last 20 away games (+9.45 Units / 37% ROI)

And here are some favorite MLB player prop bets for Brewers players for Monday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Best Bets Today:

  • Christian Yelich has hit the Hits Under in 11 of his last 15 games at home (+12.45 Units / 76% ROI)
  • Christian Yelich has hit the Singles Under in his last 10 games (+10.00 Units / 84% ROI)
  • Christian Yelich has hit the Hits Runs and RBIs Under in 17 of his last 25 games (+8.50 Units / 29% ROI)
  • Christian Yelich has hit the Home Runs Over in 2 of his last 6 games (+8.20 Units / 137% ROI)
  • Jacob Misiorowski has hit the Strikeouts Over in 9 of his last 10 games (+7.95 Units / 67% ROI)
  • team high – away
  • team high – home

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 31-19 against the Run Line (+4.15 Units / 5.49% ROI).

  • 29-22 when betting on the Moneyline for +11.4 Units / 21.69% ROI
  • 23-25 when betting on the total runs Over for -4.55 Units / -8.13% ROI
  • 25-23 when betting on the total runs Under for -0.55 Units / -0.98% ROI

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 30-20 against the Run Line (+15.45 Units / 26.16% ROI).

  • 30-20 when betting on the Moneyline for +5.1 Units / 8.07% ROI
  • 23-26 when betting on the total runs Over for -4.4 Units / -8.15% ROI
  • 26-23 when betting on the total runs Under for -0.15 Units / -0.28% ROI

Brewers vs Cardinals Home Run Prop Bets Today

Yes
Jackson Chourio +310
William Contreras +340
Andrew Vaughn +360
Jordan Walker +390
Alec Burleson +400

Brewers vs Cardinals Total Hits Prop Bets Today

Over Under
William Contreras 0.5 -275 0.5 +195
Andrew Vaughn 0.5 -235 0.5 +175
Brice Turang 0.5 -210 0.5 +155
Christian Yelich 0.5 -200 0.5 +145
Luis Rengifo 0.5 -190 0.5 +140

Brewers vs Cardinals Strikeout Prop Bets Today

Over Under
Alec Burleson 0.5 -275 0.5 +195
Jake Bauers 0.5 -220 0.5 +160
Christian Yelich 0.5 -210 0.5 +150
Nolan Gorman 1.5 -185 1.5 +135
Jackson Chourio 0.5 -185 0.5 +135

Cardinals Keys to the Game vs. the Brewers

The Cardinals are 16-8 (.667) vs top 10 scoring offenses this season Today, they face the Brewers (fourth in runs scored).

The Cardinals are 3-19 (.136) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .053.

The Cardinals are 16-9 (.640) on the road this season — 4th best in MLB; League Avg: .472.

The Cardinals are 31-19 (.620) when tied entering the 7th inning since the 2024 season — 2nd best in MLB; League Avg: .499.

Brewers Keys to the Game vs. the Cardinals

The Brewers are just 0-14 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .053.

The Brewers are 30-20 (.600) this season — 4th best in MLB; League Avg: .500.

The Brewers are 4-13 (.235) when trailing entering the 8th inning this season — 2nd best in MLB; League Avg: .105.

The Brewers are 5-1 (.833) when tied entering the 7th inning this season — 2nd best in MLB; League Avg: .500.

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have an OPS of .759 (632 PA’s) in innings 7-9 this season — 3rd best in MLB.

Cardinals hitters are slugging .274 with two-strikes this season — 5th best in MLB.

Cardinals hitters have 31 extra-base hits out of 111 total hits (just 28%) against LHP this season — 4th lowest in MLB.

Brewers hitters have an OBP of .343 (1,330 PA’s) against RHP this season — 2nd best in MLB.

Brewers hitters have come to the plate with runners in scoring position in 580 of their 1,934 plate appearances (30%) this season — highest in MLB.

Brewers hitters are slugging just .314 against LHP this season — lowest in MLB.

Brewers hitters are slugging just .350 on the road this season — tied for 3rd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 37% with two-strikes this season — lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 4th highest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — tied for 2nd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Brewers pitchers have a strikeout rate of 26% this season — best in MLB.

Brewers pitchers have a strikeout rate of 46% with two-strikes this season — 2nd best in MLB.

Opponents have a miss rate of 28% against Brewers pitchers this season — 2nd best in MLB.

Brewers pitchers have a strikeout rate of 28% in the first 5 innings this season — best in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.