• The Brewers are -155 favorites vs the Cardinals
• Cardinals vs Brewers Over / Under today: 8.5 Runs
• Cardinals / Brewers TV Channel: CATV | BRTV

The St. Louis Cardinals (+125) visit American Family Field to take on the Milwaukee Brewers (-155) on May 27, 2026. First pitch is scheduled for 1:40 pm in Milwaukee, WI.

This season, the Cardinals are 29-24 against the spread (ATS), while the Brewers are 32-20 ATS.

Cardinals vs Brewers Starting Pitchers Today:

• Cardinals starting pitcher: Dustin May 3-5, 5.10 ERA
• Brewers starting pitcher: Logan Henderson 2-1, 2.78 ERA

Cardinals vs. Brewers Odds, Run Line, Over/Under & Moneyline

Cardinals vs Brewers Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Wednesday‘s MLB game with 57.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Brewers and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Ivan Herrera has hit the Home Runs Over in 2 of his last 7 games (+12.00 Units / 171% ROI)
• Jordan Walker has hit the Runs Over in 16 of his last 25 away games (+11.90 Units / 46% ROI)
• Alec Burleson has hit the Hits Over in 19 of his last 25 games (+11.00 Units / 22% ROI)
• Nolan Gorman has hit the Walks Over in 10 of his last 15 games (+9.30 Units / 62% ROI)
• Victor Scott II has hit the Singles Under in 16 of his last 20 away games (+9.00 Units / 26% ROI)

And here are some favorite MLB player prop bets for Brewers players for Wednesday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Best Bets Today:

• Jake Bauers has hit the Hits Over in 22 of his last 25 games (+16.90 Units / 42% ROI)
• Jake Bauers has hit the Total Bases Over in 20 of his last 25 games (+15.20 Units / 46% ROI)
• Jake Bauers has hit the Singles Over in 17 of his last 25 games (+15.05 Units / 60% ROI)
• Jake Bauers has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+13.75 Units / 50% ROI)
• Christian Yelich has hit the Home Runs Over in 3 of his last 8 games (+13.20 Units / 165% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 16 of their last 25 away games (+10.05 Units / 39% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 13 of their last 18 away games (+8.60 Units / 44% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 17 of their last 25 away games (+7.60 Units / 25% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 12 of their last 22 away games (+6.15 Units / 27% ROI)
• The St. Louis Cardinals have covered the Run Line in 15 of their last 22 away games (+6.00 Units / 18% ROI)

Brewers Best Bets Today:

• The Milwaukee Brewers have covered the Run Line in 26 of their last 40 games at home (+16.45 Units / 35% ROI)
• The Milwaukee Brewers have hit the Moneyline in 17 of their last 23 games (+9.75 Units / 32% ROI)
• The Milwaukee Brewers have hit the 1st Five Innings (F5) Moneyline in 16 of their last 23 games (+9.35 Units / 30% ROI)
• The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 30 of their last 50 games at home (+9.30 Units / 16% ROI)
• The Milwaukee Brewers have hit the Team Total Over in 31 of their last 50 games at home (+9.30 Units / 16% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 31-21 against the Run Line (+1.9 Units / 2.44% ROI).

• 29-24 when betting on the Moneyline for +9.4 Units / 17.23% ROI
• 23-27 when betting on the total runs Over for -6.7 Units / -11.52% ROI
• 27-23 when betting on the total runs Under for +1.45 Units / 2.48% ROI

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 32-20 against the Run Line (+16.1 Units / 25.74% ROI).

• 32-20 when betting on the Moneyline for +6.1 Units / 8.9% ROI
• 23-28 when betting on the total runs Over for -7.65 Units / -13.36% ROI
• 28-23 when betting on the total runs Under for +2.85 Units / 4.97% ROI

Brewers vs Cardinals Home Run Prop Bets Today

Brewers vs Cardinals Total Hits Prop Bets Today

Brewers vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Brewers

The Cardinals are 16-10 (.615) vs top 10 scoring offenses this season Today, they face the Brewers (fourth in runs scored).

The Cardinals are 3-21 (.125) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .053.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals are 31-19 (.620) when tied entering the 7th inning since the 2024 season — 2nd best in MLB; League Avg: .499.

Brewers Keys to the Game vs. the Cardinals

The Brewers are just 0-14 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .053.

The Brewers are 4-13 (.235) when trailing entering the 8th inning this season — 2nd best in MLB; League Avg: .102.

The Brewers are 5-1 (.833) when tied entering the 7th inning this season — 2nd best in MLB; League Avg: .500.

The Brewers are 28-5 (.848) when allowing 4 or fewer runs this season — 5th best in MLB; League Avg: .719.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

The Cardinals are batting just .209 with two outs this season — 5th lowest in MLB.

Cardinals hitters have 70 extra-base hits out of 246 total hits (just 28%) against starting pitchers this season — lowest in MLB.

Cardinals hitters have put 40% of their swings in play against LHP this season — 3rd highest in MLB.

Brewers Hitting Stats & Trends

Brewers hitters are slugging just .350 on the road this season — 3rd lowest in MLB.

Brewers hitters are slugging just .368 this season — 3rd lowest in MLB.

Brewers hitters have 34 extra-base hits out of 127 total hits (just 27%) against LHP this season — 3rd lowest in MLB.

Brewers hitters have an OBP of .387 (603 PA’s) with runners in scoring position this season — best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 23% against Cardinals pitchers this season — tied for 3rd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 17% with runners in scoring position this season — lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 3rd highest in MLB.

Cardinals pitchers have a strikeout rate of just 38% with two-strikes this season — 2nd lowest in MLB.

Brewers Pitching Stats & Trends

Brewers pitchers have a strikeout rate of 27% this season — best in MLB.

Brewers pitchers have a strikeout rate of 47% with two-strikes this season — 2nd best in MLB.

Opponents have a miss rate of 28% against Brewers pitchers this season — tied for best in MLB.

Brewers pitchers have a strikeout rate of 28% in the first 5 innings this season — best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Cardinals vs Brewers and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.