• The Brewers are -190 favorites vs the Cardinals
• Cardinals vs Brewers Over / Under today: 7.5 Runs
• Cardinals / Brewers TV Channel: CATV | BRTV

The St. Louis Cardinals (+154) visit American Family Field to take on the Milwaukee Brewers (-190) on September 26, 2026. First pitch is scheduled for 7:10 pm in Milwaukee, WI.

This season, the Cardinals are 77-83 against the spread (ATS), while the Brewers are 83-77 ATS.

Cardinals vs Brewers Starting Pitchers Today:

• Cardinals starting pitcher: Quinn Mathews 2-3, 3.71 ERA
• Brewers starting pitcher: Dustin May 7-9, 4.72 ERA

Cardinals vs. Brewers Odds, Run Line, Over/Under & Moneyline

Cardinals vs Brewers Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Saturday‘s MLB game with 61.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Brewers and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Singles Over in 19 of his last 25 away games (+15.35 Units / 58% ROI)
• Nathan Church has hit the Hits Over in 21 of his last 25 away games (+14.45 Units / 35% ROI)
• Masyn Winn has hit the Total Bases Under in 18 of his last 25 away games (+14.10 Units / 46% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+12.35 Units / 41% ROI)
• Alec Burleson has hit the RBIs Over in 12 of his last 20 away games (+10.75 Units / 53% ROI)

And here are some favorite MLB player prop bets for Brewers players for Saturday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Best Bets Today:

• William Contreras has hit the Home Runs Over in 4 of his last 7 games at home (+18.70 Units / 267% ROI)
• Joey Ortiz has hit the Total Bases Over in 17 of his last 20 games (+15.60 Units / 53% ROI)
• Joey Ortiz has hit the Hits Over in 18 of his last 20 games (+13.80 Units / 38% ROI)
• William Contreras has hit the RBIs Over in 15 of his last 25 games (+12.30 Units / 49% ROI)
• David Hamilton has hit the Singles Over in 16 of his last 25 games (+11.95 Units / 48% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 23 of their last 40 away games (+15.15 Units / 35% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 34 of their last 50 away games (+14.15 Units / 24% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 29 of their last 45 games (+13.35 Units / 27% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 29 of their last 45 games (+10.15 Units / 19% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 11 games (+9.05 Units / 64% ROI)

Brewers Best Bets Today:

• The Milwaukee Brewers have hit the 1st Five Innings (F5) Moneyline in 25 of their last 45 games (+11.70 Units / 16% ROI)
• The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 25 games at home (+11.30 Units / 40% ROI)
• The Milwaukee Brewers have hit the Moneyline in 26 of their last 35 games at home (+10.75 Units / 18% ROI)
• The Milwaukee Brewers have covered the Run Line in 24 of their last 45 games at home (+8.95 Units / 19% ROI)
• The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 17 of their last 25 games at home (+8.00 Units / 28% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 86-71 against the Run Line (-1.6 Units / -0.72% ROI).

• 77-83 when betting on the Moneyline for -0.75 Units / -0.43% ROI
• 74-79 when betting on the total runs Over for -13.55 Units / -7.66% ROI
• 79-74 when betting on the total runs Under for -2.35 Units / -1.34% ROI

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 83-77 against the Run Line (+16.55 Units / 9.07% ROI).

• 101-59 when betting on the Moneyline for +20.1 Units / 8.49% ROI
• 72-83 when betting on the total runs Over for -18.75 Units / -10.66% ROI
• 83-72 when betting on the total runs Under for +4.05 Units / 2.3% ROI

Cardinals Keys to the Game vs. the Brewers

The Cardinals are just 6-16 (.273) when tied entering the 8th inning this season — 2nd lowest in MLB.

The Cardinals are just 29-18 (.617) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are 9-59 (.132) when trailing entering the 8th inning this season — 5th best in MLB.

The Cardinals are just 105-53 (.665) when they’ve had 10 or more hits since the 2024 season — 3rd lowest in MLB.

Brewers Keys to the Game vs. the Cardinals

The Brewers are 17-3 (.850) when tied entering the 7th inning this season — best in MLB.

The Brewers are 20-17 (.541) when their opponents score in the first inning this season — 2nd best in MLB.

The Brewers are 13-45 (.224) when trailing entering the 7th inning this season — best in MLB.

The Brewers are 11-47 (.190) when trailing entering the 8th inning this season — best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 20% of their PA’s against LHP this season — 4th best in MLB.

Cardinals hitters have an OPS of just .976 (1,054 PA’s) with the pitcher behind in the count this season — 2nd lowest in MLB.

Cardinals hitters have an OPS of just .662 (2,971 PA’s) at home this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .357 at home this season — 2nd lowest in MLB.

Brewers Hitting Stats & Trends

Brewers hitters have an OBP of .346 (4,331 PA’s) against RHP this season — best in MLB.

The Brewers are batting .404 on the first pitch of at-bats this season — best in MLB.

Brewers hitters have come to the plate with runners in scoring position in 1,845 of their 6,229 plate appearances (30%) this season — highest in MLB.

Brewers hitters have an OBP of .340 (6,229 PA’s) this season — best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — 4th highest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 38% of their games on the road this season — tied for lowest in MLB.

Cardinals pitchers have allowed an exit velocity over 105 MPH 404 times this season — 2nd most in MLB.

Cardinals pitchers have a strike rate of just 62% this season — 3rd lowest in MLB.

Brewers Pitching Stats & Trends

The Brewers have won 60% of home games in which their opponents scored first this season — highest in MLB.

The Brewers have won 49% of games in which their opponents scored first this season — highest in MLB.

The longest HR allowed by the Brewers pitchers this season traveled 523.9 feet — — 2nd longest in MLB

Opponents have a miss rate of 27% against Brewers pitchers this season — 5th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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