• The Brewers are -250 favorites vs the Cardinals
• Cardinals vs Brewers Over / Under today: 7 Runs
• Cardinals / Brewers TV Channel: CATV | BRTV

The St. Louis Cardinals (+200) visit American Family Field to take on the Milwaukee Brewers (-250) on September 27, 2026. First pitch is scheduled for 3:10 pm in Milwaukee, WI.

This season, the Cardinals are 77-84 against the spread (ATS), while the Brewers are 83-78 ATS.

Cardinals vs Brewers Starting Pitchers Today:

• Cardinals starting pitcher: Andre Pallante 12-8, 3.62 ERA
• Brewers starting pitcher: Jacob Misiorowski 15-5, 1.86 ERA

Cardinals vs. Brewers Odds, Run Line, Over/Under & Moneyline

Cardinals vs Brewers Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Sunday‘s MLB game with 69.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Singles Over in 19 of his last 25 away games (+15.50 Units / 59% ROI)
• Nathan Church has hit the Hits Over in 21 of his last 25 away games (+14.85 Units / 37% ROI)
• JJ Wetherholt has hit the Walks Under in 17 of his last 20 games (+12.60 Units / 35% ROI)
• Alec Burleson has hit the Home Runs Over in 3 of his last 7 away games (+12.20 Units / 174% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+11.75 Units / 38% ROI)

And here are some favorite MLB player prop bets for Brewers players for Sunday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Best Bets Today:

• Brice Turang has hit the Home Runs Over in 3 of his last 5 games at home (+21.00 Units / 420% ROI)
• Joey Ortiz has hit the Total Bases Over in 17 of his last 20 games (+15.60 Units / 53% ROI)
• Joey Ortiz has hit the Hits Over in 18 of his last 20 games (+13.80 Units / 38% ROI)
• Sal Frelick has hit the Singles Under in 19 of his last 25 games (+13.20 Units / 48% ROI)
• William Contreras has hit the RBIs Over in 15 of his last 25 games (+12.30 Units / 49% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 23 of their last 40 away games (+15.25 Units / 36% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 28 of their last 40 away games (+13.75 Units / 29% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 29 of their last 45 games (+13.45 Units / 27% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 29 of their last 45 games (+10.30 Units / 19% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 12 games (+7.90 Units / 52% ROI)

Brewers Best Bets Today:

• The Milwaukee Brewers have hit the 1st Five Innings (F5) Moneyline in 29 of their last 50 games (+14.20 Units / 18% ROI)
• The Milwaukee Brewers have hit the Moneyline in 28 of their last 40 games (+12.90 Units / 22% ROI)
• The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 30 games at home (+12.25 Units / 36% ROI)
• The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 20 of their last 30 games at home (+8.95 Units / 26% ROI)
• The Milwaukee Brewers have covered the Run Line in 26 of their last 50 games at home (+8.40 Units / 16% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 87-71 against the Run Line (-0.6 Units / -0.27% ROI).

• 77-84 when betting on the Moneyline for -1.75 Units / -0.99% ROI
• 74-80 when betting on the total runs Over for -14.65 Units / -8.24% ROI
• 80-74 when betting on the total runs Under for -1.35 Units / -0.77% ROI

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 83-78 against the Run Line (+15.55 Units / 8.47% ROI).

• 102-59 when betting on the Moneyline for +21.1 Units / 8.85% ROI
• 72-84 when betting on the total runs Over for -19.85 Units / -11.22% ROI
• 84-72 when betting on the total runs Under for +5.05 Units / 2.85% ROI

Cardinals Keys to the Game vs. the Brewers

The Cardinals are just 29-18 (.617) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 6-16 (.273) when tied entering the 8th inning this season — 2nd lowest in MLB.

The Cardinals are 9-60 (.130) when trailing entering the 8th inning this season — 5th best in MLB.

The Cardinals are just 13-27 (.325) when tied entering the 8th inning since the 2025 season — lowest in MLB.

Brewers Keys to the Game vs. the Cardinals

The Brewers are 17-3 (.850) when tied entering the 7th inning this season — best in MLB.

The Brewers are 20-17 (.541) when their opponents score in the first inning this season — 2nd best in MLB.

The Brewers are 13-45 (.224) when trailing entering the 7th inning this season — best in MLB.

The Brewers are 11-47 (.190) when trailing entering the 8th inning this season — best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters are slugging just .499 with the pitcher behind in the count this season — lowest in MLB.

Cardinals hitters are slugging just .357 at home this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .379 this season — tied for 2nd lowest in MLB.

Cardinals hitters have an OBP of just .304 (2,971 PA’s) at home this season — 2nd lowest in MLB.

Brewers Hitting Stats & Trends

The Brewers are batting .402 on the first pitch of at-bats this season — best in MLB.

Brewers hitters have an OBP of .346 (4,346 PA’s) against RHP this season — best in MLB.

Brewers hitters have come to the plate with runners in scoring position in 1,857 of their 6,265 plate appearances (30%) this season — highest in MLB.

Brewers hitters have an OBP of .341 (6,265 PA’s) this season — best in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed an average Exit Velocity of 89.4 MPH this season (4,193 balls in play) — 3rd highest in MLB

Cardinals pitchers have a strikeout rate of just 20% with runners in scoring position this season — 5th lowest in MLB.

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 3rd highest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 38% of their games on the road this season — tied for lowest in MLB.

Brewers Pitching Stats & Trends

The Brewers have won 61% of home games in which their opponents scored first this season — highest in MLB.

The Brewers have won 49% of games in which their opponents scored first this season — highest in MLB.

The longest HR allowed by the Brewers pitchers this season traveled 523.9 feet — — 2nd longest in MLB

Brewers pitchers have an ERA of 3.15 (727.2 IP) at home this season — best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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