• The Cubs are -185 favorites vs the Cardinals
• Cardinals vs Cubs Over / Under today: 9 Runs
• Cardinals / Cubs TV Channel: MARQ | CATV

The St. Louis Cardinals (+150) visit Wrigley Field to take on the Chicago Cubs (-185) on August 15, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Cardinals are 61-61 against the spread (ATS), while the Cubs are 60-61 ATS.

Cardinals vs Cubs Starting Pitchers Today:

• Cardinals starting pitcher: Michael McGreevy 4-9, 3.69 ERA
• Cubs starting pitcher: Matthew Boyd 8-1, 3.55 ERA

Cardinals vs. Cubs Odds, Run Line, Over/Under & Moneyline

Cardinals vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Saturday‘s MLB game with 61.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Everson Pereira has hit the Home Runs Over in 2 of his last 4 games (+17.50 Units / 438% ROI)
• Blaze Jordan has hit the Runs Under in 21 of his last 25 games (+12.90 Units / 22% ROI)
• Alec Burleson has hit the Total Bases Over in 17 of his last 25 away games (+11.10 Units / 43% ROI)
• JJ Wetherholt has hit the Hits Under in 15 of his last 25 games (+10.30 Units / 33% ROI)
• Jimmy Crooks III has hit the Hits Runs and RBIs Under in 17 of his last 25 games (+8.35 Units / 26% ROI)

And here are some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Alex Bregman has hit the Home Runs Over in 3 of his last 8 games (+14.20 Units / 177% ROI)
• Seiya Suzuki has hit the Total Bases Over in 17 of his last 25 games at home (+10.30 Units / 36% ROI)
• Seiya Suzuki has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+10.25 Units / 34% ROI)
• Pete Crow-Armstrong has hit the Singles Under in 19 of his last 25 games (+10.20 Units / 30% ROI)
• Michael Conforto has hit the Runs Under in 13 of his last 15 games at home (+10.10 Units / 40% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 29 of their last 45 games (+13.75 Units / 28% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 26 of their last 50 away games (+12.05 Units / 23% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 24 games (+9.45 Units / 32% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 away games (+9.40 Units / 15% ROI)
• The St. Louis Cardinals have hit the Moneyline in 26 of their last 50 away games (+7.20 Units / 14% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 33 of their last 50 games (+23.35 Units / 40% ROI)
• The Chicago Cubs have hit the Moneyline in 31 of their last 45 games (+14.70 Units / 26% ROI)
• The Chicago Cubs have hit the Team Total Over in 32 of their last 50 games (+10.50 Units / 17% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+8.35 Units / 18% ROI)
• The Chicago Cubs have hit the Game Total Over in 28 of their last 50 games (+4.95 Units / 9% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 66-53 against the Run Line (-1.8 Units / -1.05% ROI).

• 61-61 when betting on the Moneyline for +4.85 Units / 3.66% ROI
• 48-68 when betting on the total runs Over for -27.3 Units / -20.27% ROI
• 68-48 when betting on the total runs Under for +15.1 Units / 11.29% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 60-61 against the Run Line (+2.25 Units / 1.56% ROI).

• 72-51 when betting on the Moneyline for +8 Units / 4.85% ROI
• 65-56 when betting on the total runs Over for +4 Units / 2.95% ROI
• 56-65 when betting on the total runs Under for -14.95 Units / -11.05% ROI

Cardinals Keys to the Game vs. the Cubs

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

Cubs Keys to the Game vs. the Cardinals

The Cubs are 7-2 (.778) this season — tied for 2nd best in MLB.

The Cubs are 7-2 (.778) when allowing 5 or more extra base hits this season — tied for 2nd best in MLB.

The Cubs are 7-2 (.778) since the 2025 season — tied for 2nd best in MLB.

The Cubs are 7-2 (.778) when allowing 5 or more extra base hits since the 2025 season — tied for 2nd best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters are slugging just .378 against RHP this season — 2nd lowest in MLB.

Cardinals hitters have 214 extra-base hits out of 690 total hits (just 31%) against RHP this season — tied for lowest in MLB.

The Cardinals are batting just .222 with two outs this season — 4th lowest in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .356 (1,321 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OPS of .798 (1,321 PA’s) against LHP this season — best in MLB.

The Cubs are batting .268 against LHP this season — 2nd best in MLB.

Cubs hitters are slugging .443 against LHP this season — tied for 2nd best in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed their opponents to score first in just 34% of their games on the road this season — 2nd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — 4th lowest in MLB.

Cardinals pitchers have induced opposing hitters to ground into 108 double plays in 915 opportunities (12%) this season — best in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .213 against Cubs pitchers with runners on base this season — 2nd best in MLB.

Cubs pitchers have walked 8% of batters this season — tied for 4th best in MLB.

In games when their opponents have scored three or more runs in an inning, the Cubs have still managed to win 39% of the time this season — highest in MLB.

Cubs pitchers have won 39% of games in which they have allowed their opponent to score in three different innings this season — highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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