• The Cubs are -185 favorites vs the Cardinals
• Cardinals vs Cubs Over / Under today: 8.5 Runs
• Cardinals / Cubs TV Channel: ABC

The St. Louis Cardinals (+150) visit Wrigley Field to take on the Chicago Cubs (-185) on August 16, 2026. First pitch is scheduled for 3:15 pm in Chicago, IL.

This season, the Cardinals are 62-61 against the spread (ATS), while the Cubs are 60-62 ATS.

Cardinals vs Cubs Starting Pitchers Today:

• Cardinals starting pitcher: Hunter Dobbins 2-3, 3.40 ERA
• Cubs starting pitcher: Edward Cabrera 5-4, 5.15 ERA

Cardinals vs. Cubs Odds, Run Line, Over/Under & Moneyline

Cardinals vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 57.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• JJ Wetherholt has hit the Hits Under in 16 of his last 25 games (+14.50 Units / 49% ROI)
• Alec Burleson has hit the Total Bases Over in 17 of his last 25 away games (+11.25 Units / 44% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 14 of his last 20 away games (+9.55 Units / 42% ROI)
• JJ Wetherholt has hit the Walks Over in 6 of his last 7 away games (+8.90 Units / 127% ROI)
• Alec Burleson has hit the Home Runs Over in 2 of his last 4 away games (+7.80 Units / 195% ROI)

And here are some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Nico Hoerner has hit the Home Runs Over in 2 of his last 8 games at home (+22.00 Units / 275% ROI)
• Seiya Suzuki has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+12.25 Units / 40% ROI)
• Seiya Suzuki has hit the Walks Over in 16 of his last 25 games at home (+11.75 Units / 47% ROI)
• Seiya Suzuki has hit the Total Bases Over in 17 of his last 25 games at home (+10.40 Units / 37% ROI)
• Nico Hoerner has hit the Singles Over in 19 of his last 25 games (+10.25 Units / 27% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 29 of their last 45 games (+13.75 Units / 28% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 26 of their last 50 away games (+12.50 Units / 24% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 away games (+9.40 Units / 15% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 25 games (+8.45 Units / 28% ROI)
• The St. Louis Cardinals have hit the Moneyline in 26 of their last 50 away games (+7.70 Units / 15% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 33 of their last 50 games (+23.45 Units / 40% ROI)
• The Chicago Cubs have hit the Moneyline in 34 of their last 50 games (+14.45 Units / 22% ROI)
• The Chicago Cubs have hit the Team Total Over in 32 of their last 50 games (+10.35 Units / 17% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 27 of their last 45 games at home (+7.15 Units / 13% ROI)
• The Chicago Cubs have hit the Game Total Over in 29 of their last 50 games (+7.05 Units / 13% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 67-53 against the Run Line (-0.8 Units / -0.46% ROI).

• 62-61 when betting on the Moneyline for +6.45 Units / 4.83% ROI
• 49-68 when betting on the total runs Over for -26.3 Units / -19.37% ROI
• 68-49 when betting on the total runs Under for +14 Units / 10.38% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 60-62 against the Run Line (+1.25 Units / 0.86% ROI).

• 72-52 when betting on the Moneyline for +6.15 Units / 3.69% ROI
• 66-56 when betting on the total runs Over for +5 Units / 3.66% ROI
• 56-66 when betting on the total runs Under for -16.05 Units / -11.77% ROI

Cubs vs Cardinals Home Run Prop Bets Today

Cubs vs Cardinals Total Hits Prop Bets Today

Cubs vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Cubs

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

Cubs Keys to the Game vs. the Cardinals

The Cubs are 7-3 (.700) this season — tied for 3rd best in MLB.

The Cubs were 48-6 (.889) when they had 10 or more hits in the 2025 season — best in MLB; League Avg: .743.

The Cubs are 7-3 (.700) since the 2025 season — tied for 3rd best in MLB.

The Cubs were 40-9 (.816) when they scored in the first inning in the 2025 season — best in MLB; League Avg: .636.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters are slugging just .361 at home this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .378 against RHP this season — 2nd lowest in MLB.

Cardinals hitters have an OPS of just .982 (800 PA’s) with the pitcher behind in the count this season — 2nd lowest in MLB.

Cubs Hitting Stats & Trends

The Cubs are batting .268 against LHP this season — 2nd best in MLB.

Cubs hitters have an OBP of .356 (1,324 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OPS of .798 (1,324 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OBP of .364 (497 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have induced opposing hitters to ground into 111 double plays in 920 opportunities (12%) this season — best in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 3rd highest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 33% of their games on the road this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have won 38% of games in which they have allowed their opponent to score in three different innings this season — highest in MLB.

Opponents have a groundball batting average of just .210 against Cubs pitchers with runners on base this season — best in MLB.

Cubs pitchers have picked-off 19 runners from first base this season — most in MLB.

In games when their opponents have scored three or more runs in an inning, the Cubs have still managed to win 38% of the time this season — highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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