• The Cubs are -165 favorites vs the Cardinals
• Cardinals vs Cubs Over / Under today: 8 Runs
• Cardinals / Cubs TV Channel: FOX

The St. Louis Cardinals (+135) visit Wrigley Field to take on the Chicago Cubs (-165) on July 4, 2026. First pitch is scheduled for 8:08 pm in Chicago, IL.

This season, the Cardinals are 46-39 against the spread (ATS), while the Cubs are 36-51 ATS.

Cardinals vs Cubs Starting Pitchers Today:

• Cardinals starting pitcher: Kyle Leahy 6-4, 4.11 ERA
• Cubs starting pitcher: Shota Imanaga 5-6, 4.31 ERA

Cardinals vs. Cubs Odds, Run Line, Over/Under & Moneyline

Cardinals vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Saturday‘s MLB game with 55.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Home Runs Over in 3 of his last 4 games (+25.50 Units / 638% ROI)
• Alec Burleson has hit the RBIs Over in 16 of his last 25 games (+15.30 Units / 61% ROI)
• Masyn Winn has hit the Runs Over in 15 of his last 25 games (+12.35 Units / 49% ROI)
• Jose Fermin has hit the Total Bases Over in 19 of his last 25 games (+12.20 Units / 33% ROI)
• Masyn Winn has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+10.75 Units / 37% ROI)

And here are some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Nico Hoerner has hit the Hits Under in 20 of his last 25 games at home (+18.05 Units / 40% ROI)
• Pete Crow-Armstrong has hit the Home Runs Over in 6 of his last 9 games at home (+15.40 Units / 171% ROI)
• Nico Hoerner has hit the Hits Runs and RBIs Under in 19 of his last 25 games at home (+13.65 Units / 48% ROI)
• Michael Busch has hit the Runs Under in 20 of his last 25 games at home (+13.60 Units / 37% ROI)
• Pete Crow-Armstrong has hit the Total Bases Over in 18 of his last 25 games at home (+12.35 Units / 43% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Team Total Over in 29 of their last 40 away games (+16.60 Units / 35% ROI)
• The St. Louis Cardinals have covered the Run Line in 24 of their last 35 away games (+10.35 Units / 20% ROI)
• The St. Louis Cardinals have hit the Moneyline in 23 of their last 40 away games (+9.25 Units / 22% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 29 of their last 50 games (+8.20 Units / 15% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 10 of their last 13 away games (+7.75 Units / 51% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Moneyline in 15 of their last 20 games (+9.10 Units / 34% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 games (+8.45 Units / 14% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 12 of their last 21 games (+8.15 Units / 28% ROI)
• The Chicago Cubs have hit the Game Total Over in 11 of their last 14 games (+7.70 Units / 49% ROI)
• The Chicago Cubs have covered the Run Line in 9 of their last 14 games (+7.20 Units / 46% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 49-34 against the Run Line (+5.45 Units / 4.5% ROI).

• 46-39 when betting on the Moneyline for +10.65 Units / 11.66% ROI
• 37-44 when betting on the total runs Over for -11.4 Units / -12.2% ROI
• 44-37 when betting on the total runs Under for +3.15 Units / 3.36% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 36-51 against the Run Line (-15 Units / -14.56% ROI).

• 49-39 when betting on the Moneyline for -0.25 Units / -0.21% ROI
• 48-39 when betting on the total runs Over for +5.65 Units / 5.81% ROI
• 39-48 when betting on the total runs Under for -13.1 Units / -13.56% ROI

Cubs vs Cardinals Home Run Prop Bets Today

Cubs vs Cardinals Total Hits Prop Bets Today

Cubs vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Cubs

The Cardinals are 21-14 (.600) vs top 10 scoring offenses this season Today, they face the Cubs (third in runs scored).

The Cardinals are just 11-18 (.379) when tied entering the 8th inning since the 2025 season — 4th lowest in MLB; League Avg: .500.

The Cardinals are 32-22 (.593) when tied entering the 7th inning since the 2024 season — 4th best in MLB; League Avg: .499.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

Cubs Keys to the Game vs. the Cardinals

The Cubs are 4-37 (.098) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .055.

The Cubs are 37-3 (.925) when leading entering the 7th inning this season — 5th best in MLB; League Avg: .861.

The Cubs are 26-2 (.929) when they’ve had 10 or more hits this season — 2nd best in MLB; League Avg: .754.

The Cubs are 20-1 (.952) when they’ve had 5 or more XBH this season — 2nd best in MLB; League Avg: .783.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters have 121 extra-base hits out of 407 total hits (just 30%) against starting pitchers this season — lowest in MLB.

Cardinals hitters have struck out in just 20% of their PA’s this season — 4th best in MLB.

Cardinals hitters have an OBP of .332 (1,635 PA’s) on the road this season — tied for 2nd best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OPS of .778 (971 PA’s) against LHP this season — 2nd best in MLB.

The Cubs have scored first in just 24% of their games against division opponents this season — lowest in MLB.

Cubs hitters have an OBP of .369 (344 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Cubs hitters have an OBP of .351 (971 PA’s) against LHP this season — best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 22% against Cardinals pitchers this season — tied for 2nd lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — highest in MLB.

Cardinals pitchers have a strikeout rate of just 18% with runners in scoring position this season — 2nd lowest in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 89.9 MPH this season (2,238 balls in play) — highest in MLB

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .199 against Cubs pitchers with runners on base this season — best in MLB.

Cubs pitchers have picked-off 15 runners from first base this season — most in MLB.

The Cubs pitchers have allowed division opponents to score first in 76% of their games this season — highest in MLB.

Opponents have a groundball batting average of just .222 against Cubs pitchers this season — tied for 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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