Cardinals vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, Jul 5

Chicago Cubs' Ian Happ watches his grand slam off Pittsburgh Pirates starting pitcher Mitch Keller during the fifth inning of a baseball game Wednesday, Sept. 20, 2023, in Chicago. (AP Photo/Charles Rex Arbogast)
(AP Photo/Charles Rex Arbogast)
  • The Cubs are -155 favorites vs the Cardinals
  • Cardinals vs Cubs Over / Under today: 11 Runs
  • Cardinals / Cubs TV Channel: MARQ | FDMW

The St. Louis Cardinals (+130) visit Wrigley Field to take on the Chicago Cubs (-155) on Saturday, July 5, 2025. First pitch is scheduled for 2:20pm EDT in Chicago, IL, IL.

This season, the Cardinals are 47-42 against the spread (ATS), while the Cubs are 43-45 ATS.

Cardinals vs Cubs Starting Pitchers Today:

  • Cardinals starting pitcher: Matthew Liberatore 6-6, 3.71 ERA
  • Cubs starting pitcher: Drew Pomeranz 2-1, 0.00 ERA

Cardinals vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals+1.5 -160O 11 -118+130
Cubs -1.5 +135U 11 -102-155

Cardinals vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Saturday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Thomas Saggese has hit the Hits Under in 8 of his last 9 games (+10.70 Units / 119% ROI)
  • Thomas Saggese has hit the Runs Under in his last 10 games (+10.00 Units / 45% ROI)
  • Thomas Saggese has hit the Hits Runs and RBIs Under in his last 9 games (+9.00 Units / 73% ROI)
  • Thomas Saggese has hit the Total Bases Under in 8 of his last 9 games (+8.40 Units / 69% ROI)
  • Thomas Saggese has hit the Singles Under in 9 of his last 10 games (+7.80 Units / 58% ROI)

And here are some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • No trends found

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 49-40 against the Run Line (+5.5 Units / 4.62% ROI).

  • 47-42 when betting on the Moneyline for +4.8 Units / 4.72% ROI
  • 45-40 when betting on the total runs Over for -0.1 Units / -0.1% ROI
  • 40-45 when betting on the total runs Under for -8.4 Units / -8.69% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 43-45 against the Run Line (-3.33 Units / -3.19% ROI).

  • 53-35 when betting on the Moneyline for +10.85 Units / 8.54% ROI
  • 45-38 when betting on the total runs Over for +2.7 Units / 2.84% ROI
  • 38-45 when betting on the total runs Under for -10.55 Units / -10.94% ROI

Cubs vs Cardinals Home Run Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 +230 0.5 -285
Willson Contreras (STL) 0.5 +260 0.5 -325
Ian Happ (CHC) 0.5 +310 0.5 -400
Dansby Swanson (CHC) 0.5 +320 0.5 -400
Nolan Gorman (STL) 0.5 +333 0.5 -450

Cubs vs Cardinals Total Hits Prop Bets Today

Over Under
Ian Happ (CHC) 0.5 -275 0.5 +200
Carson Kelly (CHC) 0.5 -250 0.5 +190
Matt Shaw (CHC) 0.5 -220 0.5 +170
Pete Crow-Armstrong (CHC) 0.5 -220 0.5 +160
Justin Turner (CHC) 0.5 -210 0.5 +160

Cubs vs Cardinals RBI Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 -105 0.5 -120
Willson Contreras (STL) 0.5 -105 0.5 -125
Carson Kelly (CHC) 0.5 +120 0.5 -155
Alec Burleson (STL) 0.5 +120 0.5 -155
Nolan Arenado (STL) 0.5 +130 0.5 -165

Cubs vs Cardinals Strikeout Prop Bets Today

Over Under
Drew Pomeranz (CHC) 0.5 -250 0.5 +185
Matthew Liberatore (STL) 4.5 +130 4.5 -165

Opposing hitters have a chase rate of 38% (45/120) against Matthew Liberatore when he’s behind in the count this season — highest among qualified SPs in MLB; League Avg: 24% — 100th Percentile.

Matthew Liberatore has walked 4% of batters this season — tied for 4th best among qualified SPs in MLB; League Avg: 7% — 96th Percentile.

Hitters have chased 75 of Matthew Liberatore’s 166 sliders out of the zone (chase rate of 45%) this season — 3rd highest among qualified SPs in MLB; League Avg: 31% — 96th Percentile.

46% of Matthew Liberatore’s fastball strikeouts are located out of the zone this season — 7th highest among qualified SPs in MLB; League Avg: 35% — 90th Percentile.

Cubs Starting Pitcher Stats & Trends

83% of Drew Pomeranz’s strikeouts are on pitches in the zone this season — highest among qualified RPs in MLB; League Avg: 51% — 100th Percentile.

Drew Pomeranz has allowed an OPS of just .457 (90 PA’s) this season — 7th best among qualified RPs in MLB; League Avg: .673 — 97th Percentile.

Drew Pomeranz has allowed no extra-base hits in his last 13.1 innings pitched — Edwin Diaz has the longest active streak at 21.1.

Drew Pomeranz has allowed a slugging percentage of just .190 (15 Total Bases / 79 ABs) this season — 2nd best among qualified RPs in MLB; League Avg: .365 — 99th Percentile.

Cardinals Keys to the Game vs. the Cubs

The Cardinals are 39-1 (.975) when leading entering the 8th inning this season — 2nd best in MLB; League Avg: .908.

The Cardinals are 103-5 (.954) when leading entering the 8th inning since last season — 3rd best in MLB; League Avg: .902.

The Cardinals are 39-3 (.929) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .872.

The Cardinals are just 11-35 (.239) when scoring 4 or fewer runs this season — 5th lowest in MLB; League Avg: .296.

Cubs Keys to the Game vs. the Cardinals

The Cubs are 27-5 (.844) when they’ve had 10 or more hits this season — 4th best in MLB; League Avg: .746.

The Cubs are 21-6 (.778) when they’ve scored in the first inning this season — 3rd best in MLB; League Avg: .633.

The Cubs are 53-35 (.602) this season — tied for 3rd best in MLB; League Avg: .500.

The Cubs are 53-16 (.768) when they’ve scored in the first inning since last season — best in MLB; League Avg: .638.

Cardinals hitters have struck out in just 20% of their PA’s against RHP this season — 5th best in MLB; League Avg: 22%.

The Cardinals are batting .265 at home this season — tied for 5th best in MLB; League Avg: .250.

Cardinals hitters slugged just .507 on the first pitch of at-bats in the 2024 season — tied for 4th lowest in MLB; League Avg: .560.

The Cardinals are batting just .215 against division opponents this season — 3rd lowest in MLB; League Avg: .248.

Cubs hitters are slugging .477 on the road this season — best in MLB; League Avg: .392.

Cubs hitters have an OPS of .804 (1,755 PA’s) on the road this season — best in MLB; League Avg: .702.

Cubs hitters have an OBP of .331 (2,493 PA’s) against RHP this season — tied for 4th best in MLB; League Avg: .319.

Cubs hitters have an OPS of .786 (2,493 PA’s) against RHP this season — 3rd best in MLB; League Avg: .724.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 25%.

Cardinals pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — tied for 2nd best in MLB; League Avg: 8%.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — tied for 3rd lowest in MLB; League Avg: 42%.

Cardinals pitchers have walked 4% of batters when facing the leadoff batter in the inning over the last 14 days — best in MLB; League Avg: 7%.

Cubs pitchers have a strikeout rate of just 30% with two-strikes over the last 14 days — lowest in MLB; League Avg: 42%.

Cubs pitchers have a strikeout rate of just 15% over the last 14 days — lowest in MLB; League Avg: 22%.

Opponents have a miss rate of just 23% against Cubs pitchers this season — 2nd lowest in MLB; League Avg: 25%.

Cubs pitchers have a strikeout rate of just 38% with two-strikes this season — 2nd lowest in MLB; League Avg: 42%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.