Cardinals vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, Jul 6

Chicago Cubs' Nico Hoerner watches his RBI sacrifice fly during the fifth inning of a baseball game against the Colorado Rockies Saturday, Sept. 23, 2023, in Chicago. Chicago won 6-3. (AP Photo/Paul Beaty)
(AP Photo/Paul Beaty)
  • The Cubs are -220 favorites vs the Cardinals
  • Cardinals vs Cubs Over / Under today: 7.5 Runs
  • Cardinals / Cubs TV Channel: ESPN

The St. Louis Cardinals (+180) visit Wrigley Field to take on the Chicago Cubs (-220) on Sunday, July 6, 2025. First pitch is scheduled for 6:10pm EDT in Chicago, IL, IL.

This season, the Cardinals are 48-42 against the spread (ATS), while the Cubs are 43-46 ATS.

Cardinals vs Cubs Starting Pitchers Today:

  • Cardinals starting pitcher: Erick Fedde 3-8, 4.57 ERA
  • Cubs starting pitcher: Matthew Boyd 8-3, 2.65 ERA

Cardinals vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals+1.5 -120O 7.5 -115+180
Cubs -1.5 +100U 7.5 -105-220

Cardinals vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 63.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Alec Burleson has hit the Total Bases Over in 17 of his last 25 games (+10.50 Units / 37% ROI)
  • Alec Burleson has hit the Home Runs Over in 4 of his last 10 away games (+10.30 Units / 103% ROI)
  • Brendan Donovan has hit the Hits Under in 12 of his last 15 games (+10.05 Units / 37% ROI)
  • Victor Scott II has hit the Hits Runs and RBIs Under in 17 of his last 25 away games (+8.45 Units / 26% ROI)
  • Alec Burleson has hit the Singles Under in 11 of his last 15 games (+7.65 Units / 50% ROI)

And here are some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • Nico Hoerner has hit the Home Runs Over in 2 of his last 8 games (+18.00 Units / 225% ROI)
  • Seiya Suzuki has hit the Singles Under in 21 of his last 25 games at home (+15.70 Units / 50% ROI)
  • Matthew Boyd has hit the Strikeouts Over in 18 of his last 25 games (+10.40 Units / 34% ROI)
  • Ian Happ has hit the Total Bases Under in 17 of his last 25 games at home (+9.55 Units / 29% ROI)
  • Michael Busch has hit the RBIs Over in 6 of his last 8 games (+8.75 Units / 109% ROI)
  • The St. Louis Cardinals have covered the Run Line in 23 of their last 33 away games (+14.65 Units / 33% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 39 of their last 67 games (+10.85 Units / 14% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 50 of their last 90 games (+6.72 Units / 7% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 41 games (+6.20 Units / 12% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 20 of their last 33 away games (+5.90 Units / 16% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 45 of their last 87 games (+12.65 Units / 10% ROI)
  • The Chicago Cubs have hit the Moneyline in 51 of their last 83 games (+12.35 Units / 10% ROI)
  • The Chicago Cubs have hit the Team Total Over in 49 of their last 84 games (+7.95 Units / 8% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 8 of their last 10 games at home (+6.25 Units / 56% ROI)
  • The Chicago Cubs have hit the Game Total Over in 11 of their last 16 games (+5.45 Units / 31% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 50-40 against the Run Line (+5 Units / 4.1% ROI).

  • 48-42 when betting on the Moneyline for +5.2 Units / 5.02% ROI
  • 46-40 when betting on the total runs Over for +1.9 Units / 1.92% ROI
  • 40-46 when betting on the total runs Under for -10.7 Units / -10.81% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 43-46 against the Run Line (-3.03 Units / -2.85% ROI).

  • 53-36 when betting on the Moneyline for +10.25 Units / 7.88% ROI
  • 46-38 when betting on the total runs Over for +4.7 Units / 4.84% ROI
  • 38-46 when betting on the total runs Under for -12.85 Units / -13.01% ROI

Cubs vs Cardinals Home Run Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 +425 0.5 -600
Kyle Tucker (CHC) 0.5 +475 0.5 -650
Pete Crow-Armstrong (CHC) 0.5 +475 0.5 -650
Willson Contreras (STL) 0.5 +500 0.5 -750
Ian Happ (CHC) 0.5 +500 0.5 -700

Cubs vs Cardinals Total Hits Prop Bets Today

Over Under
Pete Crow-Armstrong (CHC) 0.5 -250 0.5 +185
Seiya Suzuki (CHC) 0.5 -235 0.5 +180
Kyle Tucker (CHC) 0.5 -235 0.5 +180
Nico Hoerner (CHC) 0.5 -220 0.5 +160
Ian Happ (CHC) 0.5 -220 0.5 +165

Cubs vs Cardinals RBI Prop Bets Today

Over Under
Pete Crow-Armstrong (CHC) 0.5 +135 0.5 -175
Seiya Suzuki (CHC) 0.5 +140 0.5 -185
Kyle Tucker (CHC) 0.5 +160 0.5 -210
Michael Busch (CHC) 0.5 +165 0.5 -220
Dansby Swanson (CHC) 0.5 +165 0.5 -220

Cubs vs Cardinals Strikeout Prop Bets Today

Over Under
Erick Fedde (STL) 3.5 -145 3.5 +110
Matthew Boyd (CHC) 5.5 +125 5.5 -160

Erick Fedde has a strikeout rate of just 15% (14 SO in 91 PAs) on low non-fastballs this season — lowest among qualified SPs in MLB; League Avg: 35% — first Percentile.

Erick Fedde had a strike rate of just 50% (539/1,077) when behind in the count in the 2024 season — 2nd lowest among qualified SPs in MLB; League Avg: 61% — third Percentile.

Erick Fedde has allowed an OBP of .322 (177 PA’s) with two-strikes this season — highest among qualified SPs in MLB; League Avg: .233 — first Percentile.

Erick Fedde had a strike rate of just 57% (522/908) in two strike counts in the 2024 season — 2nd lowest among qualified SPs in MLB; League Avg: 65% — third Percentile.

Cubs Starting Pitcher Stats & Trends

Matthew Boyd has picked-off 7 runners this season — most among among NL Starters — 100th Percentile.

Matthew Boyd had a first-pitch in-zone of 81% (21/26) in his last start — best in MLB over the last week; League Avg: 55% — 100th Percentile.

Matthew Boyd has a strikeout rate of just 9% (7 SO in 76 PAs) with runners in scoring position this season — tied for 2nd lowest among qualified SPs in MLB; League Avg: 22% — fourth Percentile.

Matthew Boyd has thrown his changeup 37% of the time (93/249) when he’s behind in the count this season — highest in MLB among starting pitchers with at least 34 total CH; League Avg: 14% — 100th Percentile.

Cardinals Keys to the Game vs. the Cubs

The Cardinals are 103-5 (.954) when leading entering the 8th inning since last season — 3rd best in MLB; League Avg: .902.

The Cardinals are just 11-35 (.239) when scoring 4 or fewer runs this season — 5th lowest in MLB; League Avg: .296.

The Cardinals are 39-1 (.975) when leading entering the 8th inning this season — 2nd best in MLB; League Avg: .908.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

Cubs Keys to the Game vs. the Cardinals

The Cubs are 26-9 (.743) after a loss this season — 2nd best in MLB; League Avg: .496.

The Cubs are 53-36 (.596) this season — 4th best in MLB; League Avg: .500.

The Cubs are 21-6 (.778) when they’ve scored in the first inning this season — 3rd best in MLB; League Avg: .633.

The Cubs are 71-42 (.628) after a loss since last season — 2nd best in MLB; League Avg: .500.

Cardinals hitters have an OPS of just .958 (675 PA’s) with the pitcher behind in the count this season — 3rd lowest in MLB; League Avg: 1.062.

Cardinals hitters have pulled just 44% of balls they’ve put into play against RHP this season — 2nd lowest in MLB; League Avg: 47%.

Cardinals hitters have struck out in just 20% of their PA’s against RHP this season — 5th best in MLB; League Avg: 22%.

Cardinals hitters slugged just .507 on the first pitch of at-bats in the 2024 season — tied for 4th lowest in MLB; League Avg: .560.

Cubs hitters have an OPS of .804 (1,755 PA’s) on the road this season — best in MLB; League Avg: .702.

Cubs hitters are slugging .477 on the road this season — best in MLB; League Avg: .392.

Cubs hitters have an OBP of just .227 (212 PA’s) against pitchers who have thrown at least 80 pitches in a game this season — lowest in MLB; League Avg: .318.

The Cubs have answered-back in 41% of innings after an opponent scores this season — highest in MLB; League Avg: 30%.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 25%.

Batters facing the Cardinals pitchers have struck out on pitches in the zone 46% of the time since last season — 2nd lowest in MLB; League Avg: 50%. since last season — 2nd lowest in MLB; League Avg: 50%.

Cardinals pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — 3rd best in MLB; League Avg: 8%.

Cardinals pitchers have a strikeout rate of just 19% this season — 3rd lowest in MLB; League Avg: 22%.

Cubs pitchers have a strikeout rate of just 15% over the last 14 days — tied for lowest in MLB; League Avg: 22%.

Opponents have a groundball rate of just 35% against Cubs pitchers over the last 14 days — lowest in MLB; League Avg: 42%.

Opponents have a miss rate of just 23% against Cubs pitchers this season — tied for 2nd lowest in MLB; League Avg: 25%.

Cubs pitchers have a strikeout rate of just 38% with two-strikes this season — 2nd lowest in MLB; League Avg: 42%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.