• The Cardinals are -130 favorites vs the Giants
• Cardinals vs Giants Over / Under today: 8.5 Runs
• Cardinals / Giants TV Channel: NSBA | CATV

The St. Louis Cardinals (-130) visit Oracle Park to take on the San Francisco Giants (+105) on September 9, 2026. First pitch is scheduled for 3:45 pm in San Francisco, CA.

This season, the Cardinals are against the spread (ATS), while the Giants are ATS.

Cardinals vs Giants Starting Pitchers Today:

• Cardinals starting pitcher: Andre Pallante 12-6, 3.53 ERA
• Giants starting pitcher: Blade Tidwell 0-2, 4.47 ERA

Cardinals vs. Giants Odds, Run Line, Over/Under & Moneyline

Cardinals vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Wednesday‘s MLB game with 54.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Giants and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Singles Over in 17 of his last 20 away games (+16.40 Units / 78% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 17 of his last 20 away games (+15.35 Units / 63% ROI)
• Nathan Church has hit the Hits Over in 18 of his last 20 away games (+14.70 Units / 44% ROI)
• Masyn Winn has hit the Total Bases Under in 17 of his last 25 away games (+11.75 Units / 36% ROI)
• Alec Burleson has hit the RBIs Over in 14 of his last 25 games (+10.70 Units / 43% ROI)

And here are some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Christian Koss has hit the Home Runs Over in 2 of his last 4 games (+19.00 Units / 475% ROI)
• Rafael Devers has hit the Total Bases Over in 18 of his last 25 games (+14.85 Units / 57% ROI)
• Bryce Eldridge has hit the Hits Over in 21 of his last 25 games (+14.20 Units / 32% ROI)
• Bryce Eldridge has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+13.90 Units / 52% ROI)
• Bryce Eldridge has hit the RBIs Over in 8 of his last 9 games at home (+13.50 Units / 150% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 28 of their last 50 away games (+15.30 Units / 28% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 21 of their last 30 games (+13.45 Units / 41% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 30 of their last 45 away games (+11.15 Units / 21% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 21 of their last 30 games (+10.15 Units / 28% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 19 games (+7.40 Units / 33% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 20 of their last 24 games (+16.35 Units / 56% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 20 of their last 24 games at home (+15.65 Units / 54% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 17 of their last 24 games at home (+13.75 Units / 47% ROI)
• The San Francisco Giants have hit the Team Total Over in 12 of their last 17 games (+6.20 Units / 31% ROI)
• The San Francisco Giants have hit the Game Total Under in 23 of their last 40 games at home (+5.40 Units / 12% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are against the Run Line ( Units / ROI).

• away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• away total over record when betting on the total runs Over for over units Units / over ROI ROI
• away total under record when betting on the total runs Under for under units Units / under ROI ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are against the Run Line ( Units / ROI).

• home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
• home total over record when betting on the total runs Over for over units Units / over ROI ROI
• home total under record when betting on the total runs Under for under units Units / under ROI ROI

Cardinals Keys to the Game vs. the Giants

The Cardinals are just 6-13 (.316) when tied entering the 8th inning this season — 3rd lowest in MLB.

The Cardinals are just 27-17 (.614) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 65-33 (.663) when they’ve had 10 or more hits since the 2025 season — 3rd lowest in MLB.

The Cardinals are just 26-35 (.426) when tied entering the 8th inning since the 2024 season — 4th lowest in MLB.

Giants Keys to the Game vs. the Cardinals

The Giants are just 1-62 (.016) when trailing entering the 7th inning this season — lowest in MLB.

The Giants are just 1-66 (.015) when trailing entering the 8th inning this season — lowest in MLB.

The Giants are just 18-73 (.198) when scoring 4 or fewer runs this season — 3rd lowest in MLB.

The Giants are just 55-9 (.859) when leading entering the 9th inning this season — 2nd lowest in MLB.

Cardinals Hitting Stats & Trends

The Cardinals are batting .281 when facing the starting pitcher for the 3rd time in a game this season — 2nd best in MLB.

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters are slugging just .381 against RHP this season — 3rd lowest in MLB.

Cardinals hitters have an OBP of .358 (661 PA’s) when facing the starting pitcher for the 3rd time in a game this season — 3rd best in MLB.

Giants Hitting Stats & Trends

Giants hitters have an OBP of just .293 (1,580 PA’s) against LHP this season — lowest in MLB.

The Giants are batting .258 with two outs this season — 2nd best in MLB.

Giants hitters are slugging .419 on the road this season — 2nd best in MLB.

Giants hitters have an OBP of just .236 (2,883 PA’s) with two-strikes this season — tied for 2nd lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — 5th highest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 5th lowest in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 89.5 MPH this season (3,526 balls in play) — tied for highest in MLB

Cardinals pitchers have allowed an average Exit Velocity of 89.5 MPH (3,526 batted balls) this season — tied for highest in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 46% against Giants pitchers this season — highest in MLB.

Giants pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Giants pitchers have a strikeout rate of just 20% this season — 4th lowest in MLB.

Giants pitchers have walked 10% of batters this season — 5th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Cardinals vs Giants and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.