- The Cardinals are +100 favorites vs the Guardians
- Cardinals vs Guardians Over / Under today: 8.5 Runs
- Cardinals / Guardians TV Channel: GDTV | FDMW
The St. Louis Cardinals (+100) visit Progressive Field to take on the Cleveland Guardians (-120) on Saturday, June 28, 2025. First pitch is scheduled for 4:10pm EDT in Cleveland, OH.
This season, the Cardinals are 45-38 against the spread (ATS), while the Guardians are 41-38 ATS.
Cardinals vs Guardians Starting Pitchers Today:
- Cardinals starting pitcher: Miles Mikolas 4-5, 4.29 ERA
- Guardians starting pitcher: Slade Cecconi 3-3, 3.41 ERA
Cardinals vs. Guardians Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Cardinals | -1.5 +165 | O 8.5 -115 | +100 |
| Guardians | +1.5 -200 | U 8.5 -105 | -120 |
Cardinals vs Guardians Prediction for Today’s Game
Based on recent trends the model predicts the Guardians will win Saturday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:
Best Cardinals Player Prop Bets Today:
- Alec Burleson has hit the Total Bases Over in 20 of his last 25 games (+17.10 Units / 56% ROI)
- Alec Burleson has hit the Home Runs Over in 4 of his last 9 games (+12.40 Units / 138% ROI)
- Alec Burleson has hit the Hits Over in 13 of his last 15 away games (+11.60 Units / 42% ROI)
- Willson Contreras has hit the RBIs Over in 14 of his last 25 games (+10.15 Units / 41% ROI)
- Victor Scott II has hit the Singles Under in 12 of his last 15 away games (+7.15 Units / 29% ROI)
And here are some favorite MLB player prop bets for Guardians players for Saturday‘s game, looking at profitable historical betting trends:
Best Guardians Player Prop Best Bets Today:
- Lane Thomas has hit the Home Runs Over in 3 of his last 5 games at home (+15.65 Units / 313% ROI)
- Bo Naylor has hit the Hits Under in 13 of his last 15 games at home (+11.50 Units / 70% ROI)
- Bo Naylor has hit the Total Bases Under in 13 of his last 15 games at home (+11.50 Units / 70% ROI)
- Bo Naylor has hit the Hits Runs and RBIs Under in 13 of his last 15 games at home (+11.40 Units / 60% ROI)
- Kyle Manzardo has hit the RBIs Under in his last 10 games (+10.00 Units / 40% ROI)
Cardinals Best Bets Today:
- The St. Louis Cardinals have covered the Run Line in 19 of their last 26 away games (+13.65 Units / 40% ROI)
- The St. Louis Cardinals have hit the Moneyline in 36 of their last 60 games (+11.85 Units / 17% ROI)
- The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 17 of their last 26 away games (+7.95 Units / 27% ROI)
- The St. Louis Cardinals have hit the Team Total Over in 47 of their last 83 games (+7.92 Units / 8% ROI)
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 21 of their last 34 games (+5.70 Units / 14% ROI)
Guardians Best Bets Today:
- The Cleveland Guardians have hit the Game Total Under in 28 of their last 43 games (+13.70 Units / 28% ROI)
- The Cleveland Guardians have hit the Team Total Under in 46 of their last 77 games (+11.84 Units / 13% ROI)
- The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 19 of their last 27 games at home (+10.65 Units / 33% ROI)
- The Cleveland Guardians have hit the Moneyline in 37 of their last 71 games (+3.50 Units / 4% ROI)
- The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 9 of their last 14 games (+3.20 Units / 19% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this season, the Cardinals are 46-37 against the Run Line (+4 Units / 3.56% ROI).
- 45-38 when betting on the Moneyline for +6.2 Units / 6.45% ROI
- 43-36 when betting on the total runs Over for +3.4 Units / 3.72% ROI
- 36-43 when betting on the total runs Under for -11.25 Units / -12.33% ROI
Guardians Against the Spread (ATS) Record
Against the spread this season, the Guardians are 41-38 against the Run Line (-3.6 Units / -3.27% ROI).
- 40-40 when betting on the Moneyline for +0.35 Units / 0.38% ROI
- 33-43 when betting on the total runs Over for -13.1 Units / -15.1% ROI
- 43-33 when betting on the total runs Under for +6.8 Units / 7.62% ROI
Guardians vs Cardinals Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Kyle Manzardo (CLE) | 0.5 +375 | 0.5 -525 |
| Alec Burleson (STL) | 0.5 +400 | 0.5 -550 |
| Lars Nootbaar (STL) | 0.5 +425 | 0.5 -600 |
| Nolan Gorman (STL) | 0.5 +450 | 0.5 -625 |
| Carlos Santana (CLE) | 0.5 +475 | 0.5 -700 |
Guardians vs Cardinals Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Masyn Winn (STL) | 0.5 -250 | 0.5 +180 |
| Willson Contreras (STL) | 0.5 -225 | 0.5 +170 |
| Kyle Manzardo (CLE) | 0.5 -210 | 0.5 +160 |
| Nolan Arenado (STL) | 0.5 -200 | 0.5 +150 |
| Daniel Schneemann (CLE) | 0.5 -200 | 0.5 +150 |
Guardians vs Cardinals RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Alec Burleson (STL) | 0.5 +150 | 0.5 -200 |
| Carlos Santana (CLE) | 0.5 +160 | 0.5 -210 |
| Kyle Manzardo (CLE) | 0.5 +165 | 0.5 -220 |
| Lars Nootbaar (STL) | 0.5 +170 | 0.5 -220 |
| Willson Contreras (STL) | 0.5 +175 | 0.5 -225 |
Guardians vs Cardinals Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Slade Cecconi (CLE) | 3.5 -165 | 3.5 +130 |
| Miles Mikolas (STL) | 3.5 -110 | 3.5 -118 |
Cardinals Starting Pitcher Stats & Trends
Right-handed hitters had a miss rate of just 15% (110/720) against Miles Mikolas in the 2024 season — lowest among qualified SPs in MLB; League Avg: 26% — first Percentile.
Opponents had a two strike miss rate of just 14% (74/529) against Miles Mikolas in the 2024 season — lowest among qualified SPs in MLB; League Avg: 25% — first Percentile.
Opponents had a miss rate of just 16% (221/1,347) against Miles Mikolas in the 2024 season — lowest among qualified SPs in MLB; League Avg: 26% — first Percentile.
Miles Mikolas allowed a slugging percentage of .519 (95 Total Bases / 183 ABs) on low non-fastballs in the 2024 season — highest among qualified SPs in MLB; League Avg: .302 — second Percentile.
Guardians Starting Pitcher Stats & Trends
Slade Cecconi has allowed a slugging percentage of .706 (125 Total Bases / 177 ABs) when going through the lineup the second time in a game since last season — highest in MLB among starting pitchers with at least 96 total IP; League Avg: .405 — 0 Percentile.
Opponents are hitting .390 (69-for-177) against Slade Cecconi when going through the lineup the second time in a game since last season — highest in MLB among starting pitchers with at least 96 total IP; League Avg: .245 — 0 Percentile.
Opponents have a chase percentage of just 17% (12/72) against Slade Cecconi in his last two starts — lowest in MLB over the last two weeks; League Avg: 29% — first Percentile.
Slade Cecconi has allowed no extra-base hits in his last 9.2 innings pitched — Brendon Little has the longest active streak at 19.2.
Cardinals Keys to the Game vs. the Guardians
The Cardinals are 37-3 (.925) when leading entering the 7th inning this season — 5th best in MLB; League Avg: .872.
The Cardinals are 37-1 (.974) when leading entering the 8th inning this season — 2nd best in MLB; League Avg: .907.
The Cardinals are 23-14 (.622) when tied entering the 7th inning since last season — 4th best in MLB; League Avg: .499.
The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.
Guardians Keys to the Game vs. the Cardinals
The Guardians are 19-0 (.950) when they’ve had 10 or more hits this season — best in MLB; League Avg: .745.
The Guardians are 103-5 (.954) when leading entering the 7th inning since last season — best in MLB; League Avg: .862.
The Guardians are 19-9 (.679) when tied entering the 7th inning since last season — 3rd best in MLB; League Avg: .499.
The Guardians are 110-3 (.973) when leading entering the 8th inning since last season — best in MLB; League Avg: .902.
Cardinals Hitting Stats & Trends
Cardinals hitters are slugging .218 on pitches out of the zone this season — 5th best in MLB; League Avg: .200.
Cardinals hitters have struck out in just 20% of their PA’s against RHP this season — tied for 4th best in MLB; League Avg: 22%.
Cardinals hitters have struck out in just 15% of their PA’s against LHP over the last 14 days — 4th best in MLB; League Avg: 21%.
The Cardinals are batting just .217 against LHP this month (24 games) — 5th lowest in MLB; League Avg: .246.
Guardians Hitting Stats & Trends
Guardians hitters have an OPS of just .562 (422 PA’s) over the last 14 days — lowest in MLB; League Avg: .721.
Guardians hitters have chased 42% of pitches out of the zone with two-strikes this season — 2nd highest in MLB; League Avg: 38%.
The Guardians are batting just .195 in righty-righty matchups this season — lowest in MLB; League Avg: .246.
Guardians hitters have an OBP of just .262 (465 PA’s) against RHP this month (22 games) — lowest in MLB; League Avg: .317.
Cardinals Pitching Stats & Trends
Cardinals pitchers have walked 7% of batters this season — tied for best in MLB; League Avg: 9%.
Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 25%.
Opponents have a miss rate of just 23% against Cardinals pitchers since last season — 2nd lowest in MLB; League Avg: 25%.
Cardinals pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — tied for 2nd best in MLB; League Avg: 8%.
Guardians Pitching Stats & Trends
Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.
Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.
The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.
Opponents have a chase percentage of just 26% against the Guardians pitchers this season — lowest in MLB; League Avg: 28%.
More MLB Reading:
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