Cardinals vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Jun 29

Cleveland Guardians' Jhonkensy Noel celebrates after hitting a two-run home run against the New York Yankees during the ninth inning in Game 3 of the baseball AL Championship Series Thursday, Oct. 17, 2024, in Cleveland.
(AP Photo/Sue Ogrocki)
  • The Cardinals are -118 favorites vs the Guardians
  • Cardinals vs Guardians Over / Under today: 8.5 Runs
  • Cardinals / Guardians TV Channel: Roku

The St. Louis Cardinals (-118) visit Progressive Field to take on the Cleveland Guardians (-102) on Sunday, June 29, 2025. First pitch is scheduled for 12:05pm EDT in Cleveland, OH, OH.

This season, the Cardinals are 46-38 against the spread (ATS), while the Guardians are 41-39 ATS.

Cardinals vs Guardians Starting Pitchers Today:

  • Cardinals starting pitcher: Matthew Liberatore 5-6, 3.97 ERA
  • Guardians starting pitcher: Logan Allen 5-5, 4.25 ERA

Cardinals vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals-1.5 +145O 8.5 -120-118
Guardians +1.5 -175U 8.5 +100-102

Cardinals vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Sunday‘s MLB game with 54.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Alec Burleson has hit the Total Bases Over in 20 of his last 25 games (+17.10 Units / 56% ROI)
  • Alec Burleson has hit the Home Runs Over in 4 of his last 10 games (+11.40 Units / 114% ROI)
  • Willson Contreras has hit the RBIs Over in 14 of his last 25 games (+10.60 Units / 42% ROI)
  • Matthew Liberatore has hit the Walks Allowed Under in 13 of his last 15 games (+9.90 Units / 40% ROI)
  • Alec Burleson has hit the Hits Over in 12 of his last 15 away games (+9.60 Units / 37% ROI)

And here are some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Lane Thomas has hit the Home Runs Over in 3 of his last 6 games at home (+14.65 Units / 244% ROI)
  • Bo Naylor has hit the Hits Under in 13 of his last 15 games at home (+11.50 Units / 70% ROI)
  • Bo Naylor has hit the Total Bases Under in 13 of his last 15 games at home (+11.50 Units / 70% ROI)
  • Bo Naylor has hit the Hits Runs and RBIs Under in 13 of his last 15 games at home (+11.40 Units / 60% ROI)
  • Jose Ramirez has hit the Runs Under in his last 10 games (+10.05 Units / 75% ROI)
  • The St. Louis Cardinals have covered the Run Line in 20 of their last 27 away games (+14.65 Units / 40% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 37 of their last 61 games (+12.85 Units / 18% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 48 of their last 84 games (+8.92 Units / 9% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 17 of their last 27 away games (+6.55 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 21 of their last 35 games (+4.70 Units / 11% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 28 of their last 44 games (+12.55 Units / 25% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 46 of their last 78 games (+10.84 Units / 12% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 19 of their last 28 games at home (+9.15 Units / 27% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 10 of their last 15 games (+4.30 Units / 24% ROI)
  • The Cleveland Guardians have hit the Moneyline in 37 of their last 72 games (+2.30 Units / 3% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 47-37 against the Run Line (+5 Units / 4.37% ROI).

  • 46-38 when betting on the Moneyline for +7.2 Units / 7.41% ROI
  • 44-36 when betting on the total runs Over for +4.4 Units / 4.76% ROI
  • 36-44 when betting on the total runs Under for -12.4 Units / -13.42% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 41-39 against the Run Line (-4.6 Units / -4.13% ROI).

  • 40-41 when betting on the Moneyline for -0.85 Units / -0.91% ROI
  • 34-43 when betting on the total runs Over for -12.1 Units / -13.78% ROI
  • 43-34 when betting on the total runs Under for +5.65 Units / 6.25% ROI

Guardians vs Cardinals Home Run Prop Bets Today

Over Under
Nolan Gorman (STL) 0.5 +425 0.5 -600
Willson Contreras (STL) 0.5 +450 0.5 -625
Jose Ramirez (CLE) 0.5 +500 0.5 -700
David Fry (CLE) 0.5 +575 0.5 -800
Nolan Arenado (STL) 0.5 +600 0.5 -900

Guardians vs Cardinals Total Hits Prop Bets Today

Over Under
Masyn Winn (STL) 0.5 -275 0.5 +195
Nolan Arenado (STL) 0.5 -250 0.5 +185
Willson Contreras (STL) 0.5 -250 0.5 +185
Brendan Donovan (STL) 0.5 -250 0.5 +195
Lane Thomas (CLE) 0.5 -210 0.5 +155

Guardians vs Cardinals RBI Prop Bets Today

Over Under
Nolan Arenado (STL) 0.5 +140 0.5 -185
Jose Ramirez (CLE) 0.5 +150 0.5 -200
Carlos Santana (CLE) 0.5 +160 0.5 -210
Willson Contreras (STL) 0.5 +170 0.5 -225
Masyn Winn (STL) 0.5 +175 0.5 -235

Guardians vs Cardinals Strikeout Prop Bets Today

Over Under
Matthew Liberatore (STL) 4.5 +105 4.5 -140
Logan Allen (CLE) 4.5 +105 4.5 -135

Matthew Liberatore has walked 3% of batters this season — 3rd best among qualified SPs in MLB; League Avg: 7% — 97th Percentile.

Matthew Liberatore has walked 3% of batters when going through the lineup the first time in a game this season — 2nd best among qualified SPs in MLB; League Avg: 7% — 98th Percentile.

Matthew Liberatore has walked 2% of right-handed batters this season — 2nd best among qualified SPs in MLB; League Avg: 7% — 98th Percentile.

Right-handed batters are hitting .271 (74-for-273) against Matthew Liberatore this season — 10th highest among qualified SPs in MLB; League Avg: .235 — 14th Percentile.

Guardians Starting Pitcher Stats & Trends

13 of Logan Allen’s 25 breaking pitch strikeouts (52%) have been backdoor this season — 2nd highest in MLB among starting pitchers with at least 32 total IP; League Avg: 15% — 98th Percentile.

Opponents are hitting .264 (39-for-148) against Logan Allen with two-strikes this season — highest in MLB among starting pitchers with at least 32 total IP; League Avg: .169 — 0 Percentile.

Logan Allen has allowed an OBP of .317 (372 PA’s) with two-strikes since last season — 2nd highest in MLB among starting pitchers with at least 96 total IP; League Avg: .241 — first Percentile.

Logan Allen has allowed an OPS of .677 (374 PA’s) with two-strikes since last season — 2nd highest in MLB among starting pitchers with at least 96 total IP; League Avg: .505 — first Percentile.

Cardinals Keys to the Game vs. the Guardians

The Cardinals are 38-3 (.927) when leading entering the 7th inning this season — 5th best in MLB; League Avg: .872.

The Cardinals are 38-1 (.974) when leading entering the 8th inning this season — 2nd best in MLB; League Avg: .908.

The Cardinals are 102-5 (.953) when leading entering the 8th inning since last season — 3rd best in MLB; League Avg: .902.

The Cardinals are 23-14 (.622) when tied entering the 7th inning since last season — 4th best in MLB; League Avg: .499.

Guardians Keys to the Game vs. the Cardinals

The Guardians are 19-0 (.950) when they’ve had 10 or more hits this season — best in MLB; League Avg: .745.

The Guardians are 110-3 (.973) when leading entering the 8th inning since last season — best in MLB; League Avg: .902.

The Guardians are 19-9 (.679) when tied entering the 7th inning since last season — 3rd best in MLB; League Avg: .499.

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

Cardinals hitters have struck out in just 20% of their PA’s against RHP this season — tied for 4th best in MLB; League Avg: 22%.

The Cardinals are batting .265 at home this season — 5th best in MLB; League Avg: .249.

Cardinals hitters have missed on just 23% of swings this season — tied for 5th best in MLB; League Avg: 25%.

Cardinals hitters have pulled just 44% of balls they’ve put into play against RHP this season — tied for 2nd lowest in MLB; League Avg: 47%.

Guardians hitters have an OBP of just .267 (498 PA’s) against RHP this month (23 games) — lowest in MLB; League Avg: .318.

Guardians hitters have an OBP of just .275 (856 PA’s) this month (24 games) — lowest in MLB; League Avg: .316.

Guardians hitters have chased 42% of pitches out of the zone with two-strikes this season — highest in MLB; League Avg: 38%.

Guardians hitters have struck out in 32% of their PA’s in righty-righty matchups this season — highest in MLB; League Avg: 22%.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 3rd highest in MLB; League Avg: 43%.

Batters facing the Cardinals pitchers have struck out on pitches in the zone 46% of the time since last season — 2nd lowest in MLB; League Avg: 50%. since last season — 2nd lowest in MLB; League Avg: 50%.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 25%.

Batters facing the Cardinals pitchers put 41% of their swings in play this season — 2nd highest in MLB; League Avg: 37%.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

Guardians pitchers have an ERA of 2.57 (171.2 IP) against division opponents this season — best in MLB; League Avg: 4.13.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.