• The Cardinals are -105 favorites vs the Marlins
• Cardinals vs Marlins Over / Under today: 8.5 Runs
• Cardinals / Marlins TV Channel: CATV | MATV

The St. Louis Cardinals (-105) visit loanDepot park to take on the Miami Marlins (-115) on April 21, 2026. First pitch is scheduled for 6:40 pm in Miami, FL.

This season, the Cardinals are 13-9 against the spread (ATS), while the Marlins are 9-14 ATS.

Cardinals vs Marlins Starting Pitchers Today:

• Cardinals starting pitcher: Dustin May 2-2, 7.24 ERA
• Marlins starting pitcher: Chris Paddack 0-3, 5.50 ERA

Cardinals vs. Marlins Odds, Run Line, Over/Under & Moneyline

Cardinals vs Marlins Prediction for Today’s Game

Based on recent trends the model predicts the Marlins will win Tuesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Marlins and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Home Runs Over in 4 of his last 9 away games (+17.70 Units / 197% ROI)
• Jordan Walker has hit the Hits Over in 14 of his last 15 games (+13.00 Units / 44% ROI)
• Jordan Walker has hit the Runs Over in 15 of his last 25 games (+11.25 Units / 45% ROI)
• Ramon Urias has hit the Singles Under in 12 of his last 15 games (+8.35 Units / 41% ROI)
• Thomas Saggese has hit the Hits Runs and RBIs Under in 15 of his last 20 games (+8.05 Units / 28% ROI)

And here are some favorite MLB player prop bets for Marlins players for Tuesday‘s game, looking at profitable historical betting trends:

Best Marlins Player Prop Best Bets Today:

• Liam Hicks has hit the Home Runs Over in 3 of his last 10 games at home (+21.00 Units / 210% ROI)
• Jakob Marsee has hit the Hits Under in 14 of his last 20 games at home (+15.10 Units / 70% ROI)
• Jakob Marsee has hit the Hits Runs and RBIs Under in 17 of his last 20 games at home (+13.95 Units / 62% ROI)
• Graham Pauley has hit the Singles Under in 21 of his last 25 games (+13.95 Units / 29% ROI)
• Liam Hicks has hit the Total Bases Over in his last 10 games at home (+10.45 Units / 63% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 26 of their last 45 away games (+8.35 Units / 17% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 25 away games (+6.95 Units / 22% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 8 of their last 9 away games (+6.85 Units / 64% ROI)
• The St. Louis Cardinals have hit the Moneyline in 19 of their last 35 games (+6.20 Units / 17% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 4 of their last 5 away games (+3.25 Units / 61% ROI)

Marlins Best Bets Today:

• The Miami Marlins have hit the Moneyline in 24 of their last 40 games (+10.60 Units / 22% ROI)
• The Miami Marlins have hit the Team Total Over in 31 of their last 50 games (+10.25 Units / 17% ROI)
• The Miami Marlins have hit the Game Total Over in 14 of their last 20 games (+9.60 Units / 43% ROI)
• The Miami Marlins have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 21 games at home (+5.15 Units / 20% ROI)
• The Miami Marlins have covered the 1st Five Innings (F5) Run Line in 7 of their last 10 games at home (+4.05 Units / 37% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 12-9 against the Run Line (-1.05 Units / -3.2% ROI).

• 13-9 when betting on the Moneyline for +5.6 Units / 24.78% ROI
• 13-8 when betting on the total runs Over for +4.3 Units / 17.95% ROI
• 8-13 when betting on the total runs Under for -6.55 Units / -26.68% ROI

Marlins Against the Spread (ATS) Record

Against the spread this season, the Marlins are 9-14 against the Run Line (-6.6 Units / -22.15% ROI).

• 11-12 when betting on the Moneyline for -0.9 Units / -3.08% ROI
• 14-7 when betting on the total runs Over for +6.35 Units / 25.05% ROI
• 7-14 when betting on the total runs Under for -8.3 Units / -32.87% ROI

Marlins vs Cardinals Home Run Prop Bets Today

Marlins vs Cardinals Total Hits Prop Bets Today

Marlins vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Marlins

The Cardinals are 73-4 (.948) when leading entering the 8th inning since the 2025 season — 4th best in MLB; League Avg: .907.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 10-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .867.

The Cardinals are 10-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .893.

Marlins Keys to the Game vs. the Cardinals

The Marlins are just 48-66 (.421) vs the bottom 10 runs allowed teams since the 2024 season Today, they face the Cardinals (27th runs allowed).

The Marlins are just 1-10 (.091) when allowing 5 or more runs this season — tied for 2nd lowest in MLB; League Avg: .233.

The Marlins are just 8-2 (.800) when leading entering the 8th inning this season — tied for 4th lowest in MLB; League Avg: .893.

The Marlins are 11-77 (.125) when trailing entering the 8th inning since the 2025 season — tied for 4th best in MLB; League Avg: .092.

Cardinals Hitting Stats & Trends

Cardinals hitters have 17 extra-base hits out of 90 total hits (just 19%) against starting pitchers this season — lowest in MLB.

Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

The Cardinals are batting just .215 with two outs since the 2025 season — lowest in MLB.

Cardinals hitters have chased 25% of pitches out of the zone against LHP this season — 2nd lowest in MLB.

Marlins Hitting Stats & Trends

Marlins hitters are slugging just .355 against LHP since the 2025 season — tied for 3rd lowest in MLB.

Marlins hitters averaged just 3.75 pitches per plate appearance in the 2025 season — tied for lowest in MLB.

The Marlins are batting just .169 on pitches 95 mph or greater this season — lowest in MLB.

Marlins hitters are slugging just .354 against LHP since the 2024 season — lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 33% with two-strikes this season — lowest in MLB.

Opponents have a miss rate of just 19% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% this season — lowest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers since the 2025 season — lowest in MLB.

Marlins Pitching Stats & Trends

Marlins pitchers have a strikeout rate of 45% with two-strikes this season — tied for 5th best in MLB.

Opponents have a miss rate of 29% against Marlins pitchers this season — 3rd best in MLB.

Marlins pitchers had a strikeout rate of just 40% with two-strikes in the 2025 season — 5th lowest in MLB.

Marlins pitchers have an ERA of 5.07 (776.1 IP) on the road since the 2025 season — 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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