• The Marlins are -130 favorites vs the Cardinals
• Cardinals vs Marlins Over / Under today: 8.5 Runs
• Cardinals / Marlins TV Channel: CATV | MATV

The St. Louis Cardinals (+105) visit loanDepot park to take on the Miami Marlins (-130) on April 22, 2026. First pitch is scheduled for 12:10 pm in Miami, FL.

This season, the Cardinals are 14-9 against the spread (ATS), while the Marlins are 9-15 ATS.

Cardinals vs Marlins Starting Pitchers Today:

• Cardinals starting pitcher: Kyle Leahy 2-2, 5.21 ERA
• Marlins starting pitcher: Janson Junk 0-2, 4.57 ERA

Cardinals vs. Marlins Odds, Run Line, Over/Under & Moneyline

Cardinals vs Marlins Prediction for Today’s Game

Based on recent trends the model predicts the Marlins will win Wednesday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Marlins and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Home Runs Over in 4 of his last 10 away games (+16.70 Units / 167% ROI)
• Jordan Walker has hit the Runs Over in 15 of his last 25 games (+11.25 Units / 45% ROI)
• Ivan Herrera has hit the Walks Over in 12 of his last 20 games (+9.85 Units / 49% ROI)
• Jordan Walker has hit the Hits Over in 13 of his last 15 games (+9.65 Units / 32% ROI)
• Ivan Herrera has hit the Total Bases Under in 18 of his last 25 games (+7.80 Units / 19% ROI)

And here are some favorite MLB player prop bets for Marlins players for Wednesday‘s game, looking at profitable historical betting trends:

Best Marlins Player Prop Best Bets Today:

• Otto Lopez has hit the Home Runs Over in 2 of his last 9 games (+13.00 Units / 144% ROI)
• Jakob Marsee has hit the Hits Under in 13 of his last 20 games at home (+12.70 Units / 59% ROI)
• Jakob Marsee has hit the Hits Runs and RBIs Under in 16 of his last 20 games at home (+11.85 Units / 54% ROI)
• Xavier Edwards has hit the Walks Over in 7 of his last 8 games (+11.25 Units / 141% ROI)
• Graham Pauley has hit the Singles Under in 20 of his last 25 games (+11.15 Units / 23% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Team Total Over in 9 of their last 10 away games (+8.00 Units / 68% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 25 away games (+6.95 Units / 22% ROI)
• The St. Louis Cardinals have hit the Moneyline in 14 of their last 23 games (+6.60 Units / 28% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 25 of their last 45 away games (+6.15 Units / 12% ROI)
• The St. Louis Cardinals have covered the Run Line in 6 of their last 7 games (+4.55 Units / 41% ROI)

Marlins Best Bets Today:

• The Miami Marlins have hit the Game Total Over in 14 of their last 21 games (+8.40 Units / 36% ROI)
• The Miami Marlins have hit the Moneyline in 23 of their last 40 games (+8.40 Units / 17% ROI)
• The Miami Marlins have hit the Team Total Over in 30 of their last 50 games (+8.15 Units / 14% ROI)
• The Miami Marlins have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 11 games (+5.25 Units / 40% ROI)
• The Miami Marlins have covered the 1st Five Innings (F5) Run Line in 7 of their last 11 games at home (+3.05 Units / 25% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 13-9 against the Run Line (+0.25 Units / 0.74% ROI).

• 14-9 when betting on the Moneyline for +6.6 Units / 27.97% ROI
• 13-9 when betting on the total runs Over for +3.1 Units / 12.33% ROI
• 9-13 when betting on the total runs Under for -5.55 Units / -21.72% ROI

Marlins Against the Spread (ATS) Record

Against the spread this season, the Marlins are 9-15 against the Run Line (-8.1 Units / -25.88% ROI).

• 11-13 when betting on the Moneyline for -2.1 Units / -6.9% ROI
• 14-8 when betting on the total runs Over for +5.15 Units / 19.4% ROI
• 8-14 when betting on the total runs Under for -7.3 Units / -27.81% ROI

Marlins vs Cardinals Home Run Prop Bets Today

Marlins vs Cardinals Total Hits Prop Bets Today

Marlins vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Marlins

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 74-4 (.949) when leading entering the 8th inning since the 2025 season — 3rd best in MLB; League Avg: .907.

The Cardinals are 11-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .895.

The Cardinals are 7-4 (.636) on the road this season — tied for 4th best in MLB; League Avg: .462.

Marlins Keys to the Game vs. the Cardinals

The Marlins are just 1-11 (.083) when allowing 5 or more runs this season — lowest in MLB; League Avg: .234.

The Marlins are 11-78 (.124) when trailing entering the 8th inning since the 2025 season — 5th best in MLB; League Avg: .092.

The Marlins are 6-86 (.065) when trailing entering the 9th inning since the 2025 season — 5th best in MLB; League Avg: .044.

The Marlins were 65-1 (.985) when leading entering the 9th inning in the 2025 season — 3rd best in MLB; League Avg: .956.

Cardinals Hitting Stats & Trends

Cardinals hitters have 21 extra-base hits out of 98 total hits (just 21%) against starting pitchers this season — lowest in MLB.

Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

Cardinals hitters slugged just .380 against RHP in the 2025 season — tied for 3rd lowest in MLB.

Cardinals hitters have an OPS of just .943 (1,331 PA’s) with the pitcher behind in the count since the 2025 season — 2nd lowest in MLB.

Marlins Hitting Stats & Trends

Marlins hitters have put 40% of their swings in play on the first pitch of at-bats since the 2025 season — tied for highest in MLB.

Marlins hitters are slugging just .353 against LHP since the 2024 season — lowest in MLB.

Marlins hitters have 149 extra-base hits out of 559 total hits (just 27%) with two-strikes since the 2025 season — lowest in MLB.

Marlins hitters have an OBP of .288 (469 PA’s) with two-strikes this season — 3rd best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 20% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 33% with two-strikes this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% this season — lowest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers since the 2025 season — lowest in MLB.

Marlins Pitching Stats & Trends

Marlins pitchers have a strikeout rate of 27% with runners in scoring position this season — best in MLB.

Marlins pitchers had a strikeout rate of just 40% with two-strikes in the 2025 season — 5th lowest in MLB.

Marlins pitchers have an ERA of 5.07 (776.1 IP) on the road since the 2025 season — 3rd highest in MLB.

The Marlins have allowed 5.29 runs per game (476/90) on the road since the 2025 season — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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