• The Cardinals are -115 favorites vs the Nationals
• Cardinals vs Nationals Over / Under today: 8 Runs
• Cardinals / Nationals TV Channel: CATV | NATV

The St. Louis Cardinals (-115) visit Nationals Park to take on the Washington Nationals (-105) on April 6, 2026. First pitch is scheduled for 6:45 pm in Washington, DC.

This season, the Cardinals are 5-4 against the spread (ATS), while the Nationals are 5-4 ATS.

Cardinals vs Nationals Starting Pitchers Today:

• Cardinals starting pitcher: Andre Pallante 1-0, 0.00 ERA
• Nationals starting pitcher: Zack Littell 0-1, 5.40 ERA

Cardinals vs. Nationals Odds, Run Line, Over/Under & Moneyline

Cardinals vs Nationals Prediction for Today’s Game

Based on recent trends the model predicts the Nationals will win Monday‘s MLB game with 51.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Home Runs Over in 3 of his last 10 games (+10.90 Units / 109% ROI)
• Thomas Saggese has hit the Runs Under in his last 9 away games (+9.00 Units / 42% ROI)
• Andre Pallante has hit the Pitching Outs Under in 9 of his last 10 away games (+8.00 Units / 67% ROI)
• Ivan Herrera has hit the Walks Over in his last 5 games (+7.75 Units / 155% ROI)
• Thomas Saggese has hit the Hits Runs and RBIs Under in 12 of his last 15 games (+7.45 Units / 34% ROI)

And here are some favorite MLB player prop bets for Nationals players for Monday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Best Bets Today:

• Jacob Young has hit the Home Runs Over in 2 of his last 8 games (+28.00 Units / 350% ROI)
• Zack Littell has hit the Walks Allowed Under in his last 10 games at home (+12.25 Units / 65% ROI)
• James Wood has hit the Singles Under in 17 of his last 20 games (+12.10 Units / 38% ROI)
• Daylen Lile has hit the Hits Over in 18 of his last 25 games (+7.40 Units / 15% ROI)
• CJ Abrams has hit the Hits Runs and RBIs Over in his last 6 games (+6.55 Units / 94% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Team Total Under in 46 of their last 77 games (+10.70 Units / 12% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 64 of their last 113 games (+9.25 Units / 7% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 21 of their last 36 away games (+6.65 Units / 17% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 9 of their last 19 games (+1.30 Units / 6% ROI)
• The St. Louis Cardinals have covered the Run Line in 36 of their last 67 away games (+0.85 Units / 1% ROI)

Nationals Best Bets Today:

• The Washington Nationals have hit the 1st Five Innings (F5) Team Total Under in 42 of their last 68 games at home (+13.72 Units / 17% ROI)
• The Washington Nationals have hit the Team Total Under in 39 of their last 62 games at home (+13.30 Units / 18% ROI)
• The Washington Nationals have hit the Game Total Over in 48 of their last 87 games (+12.05 Units / 12% ROI)
• The Washington Nationals have hit the Moneyline in 13 of their last 26 games (+5.00 Units / 18% ROI)
• The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 15 of their last 26 games (+3.35 Units / 11% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 5-4 against the Run Line (-0.85 Units / -6.34% ROI).

• 5-4 when betting on the Moneyline for +2.05 Units / 22.65% ROI
• 4-4 when betting on the total runs Over for -0.4 Units / -4.1% ROI
• 4-4 when betting on the total runs Under for -0.55 Units / -5.47% ROI

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 5-4 against the Run Line (+0.9 Units / 8.96% ROI).

• 3-6 when betting on the Moneyline for -0.65 Units / -7.22% ROI
• 7-2 when betting on the total runs Over for +4.85 Units / 49.49% ROI
• 2-7 when betting on the total runs Under for -5.75 Units / -57.5% ROI

Cardinals Keys to the Game vs. the Nationals

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 28-17 (.622) when tied entering the 7th inning since the 2024 season — 3rd best in MLB; League Avg: .499.

The Cardinals are 131-8 (.942) when leading entering the 8th inning since the 2024 season — 4th best in MLB; League Avg: .904.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

Nationals Keys to the Game vs. the Cardinals

The Nationals were just 64-79 (.444) when allowing 5 or more extra base hits in the 2025 season — 3rd lowest in MLB; League Avg: .535.

The Nationals were just 31-49 (.383) at home in the 2025 season — 2nd lowest in MLB; League Avg: .542.

The Nationals were just 65-96 (.401) in the 2025 season — 3rd lowest in MLB; League Avg: .500.

The Nationals were just 11-43 (.200) when their opponents score in the first inning in the 2025 season — lowest in MLB; League Avg: .362.

Cardinals Hitting Stats & Trends

Cardinals hitters are slugging just .239 on the road this season — lowest in MLB.

Cardinals hitters slugged just .489 when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

Cardinals hitters have an OPS of just .933 (1,233 PA’s) with the pitcher behind in the count since the 2025 season — 2nd lowest in MLB.

Cardinals hitters are slugging just .481 with the pitcher behind in the count since the 2025 season — lowest in MLB.

Nationals Hitting Stats & Trends

The Nationals have scored 31 runs with two outs this season — 3rd most in MLB.

Nationals hitters are slugging .419 against LHP this season — 5th best in MLB.

Nationals hitters had an OPS of just .640 (1,704 PA’s) against LHP in the 2025 season — 3rd lowest in MLB.

Nationals hitters struck out in 25% of their PA’s against LHP in the 2025 season — 3rd highest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 19% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 15% this season — lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2025 season — tied for lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2023 season — 2nd lowest in MLB.

Nationals Pitching Stats & Trends

Nationals pitchers had an ERA of 5.34 (1424.2 IP) in the 2025 season — 2nd highest in MLB.

The Nationals allowed 1.85 runs per game (299/162) in late innings in the 2025 season — highest in MLB.

Nationals pitchers had an ERA of 5.42 (735.1 IP) at home in the 2025 season — 2nd highest in MLB.

Nationals pitchers have a strikeout rate of just 20% since the 2025 season — 3rd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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