- The Cardinals are -120 favorites vs the Nationals
- Cardinals vs Nationals Over / Under today: 8.5 Runs
- Cardinals / Nationals TV Channel: CATV | NATV
The St. Louis Cardinals (-120) visit Nationals Park to take on the Washington Nationals (+100) on April 8, 2026. First pitch is scheduled for 4:05 pm in Washington, DC.
This season, the Cardinals are 6-5 against the spread (ATS), while the Nationals are 6-4 ATS.
Cardinals vs Nationals Starting Pitchers Today:
- Cardinals starting pitcher: Michael McGreevy 0-1, 2.62 ERA
- Nationals starting pitcher: Miles Mikolas 0-2, 14.48 ERA
Cardinals vs. Nationals Odds, Run Line, Over/Under & Moneyline
Cardinals vs Nationals Prediction for Today’s Game
Based on recent trends the model predicts the Cardinals will win Wednesday‘s MLB game with 51.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:
Best Cardinals Player Prop Bets Today:
- Jordan Walker has hit the Home Runs Over in 4 of his last 8 games (+20.50 Units / 256% ROI)
- Ivan Herrera has hit the Walks Over in his last 7 games (+11.00 Units / 157% ROI)
- Ivan Herrera has hit the Runs Under in 13 of his last 15 games (+9.80 Units / 42% ROI)
- Thomas Saggese has hit the Total Bases Over in 17 of his last 25 games (+9.20 Units / 25% ROI)
- Thomas Saggese has hit the Singles Over in 16 of his last 25 away games (+7.00 Units / 26% ROI)
And here are some favorite MLB player prop bets for Nationals players for Wednesday‘s game, looking at profitable historical betting trends:
Best Nationals Player Prop Best Bets Today:
- CJ Abrams has hit the Home Runs Over in 4 of his last 6 games (+27.30 Units / 455% ROI)
- James Wood has hit the Singles Under in 20 of his last 25 games (+12.35 Units / 31% ROI)
- Daylen Lile has hit the Hits Over in 19 of his last 25 games (+9.40 Units / 18% ROI)
- CJ Abrams has hit the Hits Runs and RBIs Over in 12 of his last 15 games (+9.35 Units / 53% ROI)
- CJ Abrams has hit the Total Bases Over in 11 of his last 15 games (+7.95 Units / 41% ROI)
Cardinals Best Bets Today:
- The St. Louis Cardinals have hit the Game Total Over in 23 of their last 40 away games (+7.60 Units / 17% ROI)
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 20 away games (+4.15 Units / 17% ROI)
- The St. Louis Cardinals have hit the Team Total Under in 26 of their last 45 away games (+4.10 Units / 8% ROI)
- The St. Louis Cardinals have hit the Moneyline in 12 of their last 24 games (+2.55 Units / 10% ROI)
Nationals Best Bets Today:
- The Washington Nationals have hit the Game Total Over in 30 of their last 50 games at home (+11.20 Units / 20% ROI)
- The Washington Nationals have hit the Team Total Over in 16 of their last 21 games (+9.95 Units / 39% ROI)
- The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 22 games (+9.90 Units / 37% ROI)
- The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 15 of their last 35 games (+4.10 Units / 11% ROI)
- The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 20 of their last 35 games (+4.05 Units / 10% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this season, the Cardinals are 5-5 against the Run Line (-1.85 Units / -12.01% ROI).
- 6-5 when betting on the Moneyline for +1.95 Units / 17.33% ROI
- 6-4 when betting on the total runs Over for +1.65 Units / 13.92% ROI
- 4-6 when betting on the total runs Under for -2.9 Units / -23.39% ROI
Nationals Against the Spread (ATS) Record
Against the spread this season, the Nationals are 6-4 against the Run Line (+1.9 Units / 14.29% ROI).
- 4-7 when betting on the Moneyline for -0.75 Units / -6.7% ROI
- 9-2 when betting on the total runs Over for +6.9 Units / 57.98% ROI
- 2-9 when betting on the total runs Under for -8.1 Units / -65.59% ROI
Cardinals Keys to the Game vs. the Nationals
The Cardinals are just 8-12 (.400) when tied entering the 8th inning since the 2025 season — tied for 5th lowest in MLB; League Avg: .500.
The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.
The Cardinals are 28-18 (.609) when tied entering the 7th inning since the 2024 season — tied for 4th best in MLB; League Avg: .499.
The Cardinals are 131-8 (.942) when leading entering the 8th inning since the 2024 season — 4th best in MLB; League Avg: .903.
Nationals Keys to the Game vs. the Cardinals
The Nationals were just 31-49 (.383) at home in the 2025 season — 2nd lowest in MLB; League Avg: .542.
The Nationals are just 32-53 (.372) at home since the 2025 season — 2nd lowest in MLB; League Avg: .543.
The Nationals are just 69-103 (.399) since the 2025 season — 3rd lowest in MLB; League Avg: .500.
The Nationals were just 11-43 (.200) when their opponents score in the first inning in the 2025 season — lowest in MLB; League Avg: .362.
Cardinals Hitting Stats & Trends
Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.
Cardinals hitters have an OBP of .426 (101 PA’s) when leading off an inning this season — best in MLB.
Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 4th best in MLB.
The Cardinals are batting just .174 with two outs this season — 3rd lowest in MLB.
Nationals Hitting Stats & Trends
The Nationals are batting .306 against LHP this season — best in MLB.
Nationals hitters had an OPS of just .640 (1,704 PA’s) against LHP in the 2025 season — 3rd lowest in MLB.
Nationals hitters have an OBP of .388 (153 PA’s) against LHP this season — best in MLB.
The Nationals have scored 37 runs with two outs this season — 3rd most in MLB.
Cardinals Pitching Stats & Trends
Opponents have a miss rate of just 20% against Cardinals pitchers this season — lowest in MLB.
Cardinals pitchers had a strikeout rate of just 20% in the 2025 season — 2nd lowest in MLB.
Cardinals pitchers have a strikeout rate of just 16% this season — lowest in MLB.
Cardinals pitchers have walked 3% of batters when facing the leadoff batter in the inning this season — best in MLB.
Nationals Pitching Stats & Trends
The Nationals allowed 1.85 runs per game (299/162) in late innings in the 2025 season — highest in MLB.
Nationals pitchers have an ERA of 8.22 (46.0 IP) at home this season — highest in MLB.
Nationals pitchers have an ERA of 5.59 (781.1 IP) at home since the 2025 season — 2nd highest in MLB.
Nationals pitchers had an ERA of 5.34 (1424.2 IP) in the 2025 season — 2nd highest in MLB.
More MLB Reading:
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